Hyaluronan-tethered opioid depots: Synthetic strategies and release kinetics in vitro and in vivo

Bioconjugate Chemistry

Volumn 19, Issue 9, 2008, Pages 1767-1774

  Gianolio, Diego A ^a   Philbrook, Michael ^a   Avila, Luis Z ^a   Young, Lauren E ^a   Plate, Lars ^a   Santos, Michael R ^a   Bernasconi, Richard ^a   Liu, Hanlan ^a   Ahn, Sujin ^a   Sun, Wei ^a   Jarrett, Peter K ^a   Miller, Robert J ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CONTROLLED DRUG DELIVERY; HYALURONIC ACID; RATS; STRUCTURAL DYNAMICS; TARGETED DRUG DELIVERY;

ESTER BONDS; HALF LIVES; HYALURONAN; IN-VITRO; LC-MS-MS; OPIOIDS; PHOSPHATE-BUFFERED SALINES; RAT PLASMA; RELEASE PROFILES; VITRO AND IN VIVO;

ESTERS;

ALKYL GROUP; ALLYL COMPOUND; CODEINE; ESTER; ESTERASE; HYALURONIC ACID; HYDROXYL GROUP; HYLAN B; METHYL GROUP; MORPHINE; NALOXONE; OPIATE; PHOSPHATE BUFFERED SALINE; PROTEINASE INHIBITOR; SULFONE DERIVATIVE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL BOND; CONJUGATE; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG RELEASE; ENZYME ACTIVITY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LOADING DRUG DOSE; MALE; MASS SPECTROMETRY; NONHUMAN; RAT; STEREOSPECIFICITY; SUSTAINED DRUG RELEASE; SYNTHESIS;

RATTUS;

EID: 52249111845     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc8000479     Document Type: Article

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