Quantitative analysis of circulating plasma DNA as a tumor marker in thoracic malignancies

Clinical Chemistry

Volumn 51, Issue 1, 2005, Pages 113-118

  Herrera, Luis J ^a   Raja, Siva ^a   Gooding, William E ^b   El Hefnawy, Talal ^a   Kelly, Lori ^a   Luketich, James D ^a,b   Godfrey, Tony E ^a,b,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; DNA; NUCLEIC ACID; TUMOR MARKER;

ARTICLE; BLOOD SAMPLING; CANCER PATIENT; CANCER SCREENING; CELL DEATH; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN CELL; MONITORING; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; THORAX TUMOR;

DNA, NEOPLASM; ESOPHAGEAL NEOPLASMS; HUMANS; LUNG NEOPLASMS; PLASMA; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; THORACIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 11144252245     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2004.039263     Document Type: Article

References (19)

1. Anker P, Mulcahy H, Chen XQ, Stroun M. Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev 1999;18:65-73.
2. Fournie GJ, Martres F, Pourrat JP, Alary C, Rumeau M. Plasma DNA as cell death marker in elderly patients. Gerontology 1993;39: 215-21.
3. Fournie GJ, Courtin JP, Laval F, Chale JJ, Pourrat JP, Pujazon MC, et al. Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours. Cancer Lett 1995;91:221-7.
4. Holdenrieder S, Stieber P, Forg T, Kuhl M, Schulz L, Busch M, et al. Apoptosis in serum of patients with solid tumours. Anticancer Res 1999;19:2721-4.
5. Holdenrieder S, Stieber P, Bodenmuller H, Fertig G, Furst H, Schmeller N, et al. Nucleosomes in serum as a marker for cell death. Clin Chem Lab Med 2001;39:596-605.
6. Holdenrieder S, Stieber P, Bodenmuller H, Busch M, Fertig G, Furst H, et al. Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer 2001;95:114-20.
7. Anker P, Lefort F, Vasioukhin V, Lyautey J, Lederrey C, Chen XQ, et al. K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer. Gastroenterology 1997;112: 1114-20.
8. Anker P, Stroun M. Tumor-related alterations in circulating DNA, potential for diagnosis, prognosis and detection of minimal residual disease. Leukemia 2001;15:289-91.
9. Chen XQ, Stroun M, Magnenat JL, Nicod LP, Kurt AM, Lyautey J, et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med 1996;2:1033-5.
10. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001;61:1659-65.
11. Kawakami K, Brabender J, Lord RV, Groshen S, Greenwald BD, Krasna MJ, et al. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst 2000;92:1805-11.
12. Mulcahy HE, Lyautey J, Lederrey C, qi Chen X, Anker P, Alstead EM, et al. A prospective study of K-ras mutations in the plasma of pancreatic cancer patients. Clin Cancer Res 1998;4:271-5.
13. Silva JM, Dominguez G, Garcia JM, Gonzalez R, Villanueva MJ, Navarro F, et al. Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations. Cancer Res 1999;59:3251-6.
14. Leon SA, Shapiro B, Sklaroff DM, Yaros MJ. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977; 37:646-50.
15. Leon SA, Shapiro B, Servi P, Parsons RG. A comparison of DNA and DNA-binding protein levels in malignant disease. Eur J Cancer 1981;17:533-8.
16. Sozzi G, Conte D, Mariani L, Lo VS, Roz L, Lombardo C, et al. Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients. Cancer Res 2001;61: 4675-8.
17. Stroun M, Anker P, Maurice P, Lyautey J, Lederrey C, Beljanski M. Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology 1989;46:318-22.
18. Chang HW, Lee SM, Goodman SN, Singer G, Cho SK, Sokoll U, et al. Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. J Natl Cancer Inst 2002;94: 1697-703.
19. Sozzi G, Conte D, Leon ME, Cirincione R, Roz L, Ratcliffe C, et al. Quantification of free circulating DNA as a diagnostic marker in lung cancer. Journal of Clinical Oncology 2003;21:3902-8.