Evaluation of treatment response in depression studies using a Bayesian parametric cure rate model

Journal of Psychiatric Research

Volumn 42, Issue 14, 2008, Pages 1189-1197

  Santen, Gijs ^a   Danhof, Meindert ^a   Della Pasqua, Oscar ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antidepressant drugs; Bayesian statistics; Cure rate model; Depression; Efficacy trials; HAM D scale

Indexed keywords

FLUOXETINE; PAROXETINE; PLACEBO;

ARTICLE; BAYES THEOREM; CONTROLLED STUDY; DEPRESSION; DRUG DOSE COMPARISON; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SURVIVAL TIME; TREATMENT RESPONSE;

EID: 52149120282     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2007.11.009     Document Type: Article

References (28)

1. Bech P., Allerup P., Gram L.F., Reisby N., Rosenberg R., Jacobsen O., et al. The Hamilton depression scale. Evaluation of objectivity using logistic models. Acta Psychiatrica Scandinavica 63 (1980) 290-299
2. Brooks S.P., and Gelman A. General methods for monitoring convergence of iterative simulations. Journal of Computational and Graphical Statistics 7 (1997) 434-455
3. Chen M.H., Ibrahim J.G., and Sinha D. A new Bayesian model for survival data with a surviving fraction. Journal of American Statistical Association 94 (1999) 909-919
4. DeVeaugh-geiss J, Ascher J, Brook S. Safety and tolerability of lamotrigine in controlled monotherapy trials in mood disorders. In: 39th ACNP annual meeting, San Juan, Puerto Rico; 10-12-2000.
5. Dunner D.L., and Dunbar G.C. Optimal dose regimen for paroxetine. Journal of Clinical Psychiatry 53 Suppl. (1992) 21-26
6. Gamel J.W., and Vogel R.L. Comparison of parametric and non-parametric survival methods using simulated clinical data. Statistics in Medicine 16 (1997) 1629-1643
7. Gelman A., and Rubin D.B. Inference from iterative simulation using multiple sequences. Statistical Science 7 (1992) 457-511
8. Golden R.N., Nemeroff C.B., McSorley P., Pitts C.D., and Dube E.M. Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression. Journal of Clinical Psychiatry 63 (2002) 577-584
9. Hamilton M. A rating scale for depression. Journal of Neurology and Neurosurgical Psychiatry 23 (1960) 56-62
10. Hennen J. Statistical methods for longitudinal research on bipolar disorders. Bipolar Disorders 5 (2003) 156-168
11. Khan A., Warner H.A., and Brown W.A. Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the food and drug administration database. Archives of General Psychiatry 57 (2000) 311-317
12. Laska E.M., and Siegel C. Characterizing onset in psychopharmacological clinical trials. Psychopharmacology Bulletin 31 (1995) 29-35
13. Lee S., Walker J.R., Jakul L., and Sexton K. Does elimination of placebo responders in a placebo run-in increase the treatment effect in randomized clinical trials? A meta-analytic evaluation. Depress Anxiety 19 (2004) 10-19
14. Lunn D.J., Thomas A., Best N., and Spiegelhalter D. WinBUGS - a Bayesian modelling framework: concepts, structure, and extensibility. Statistics and Computing 10 (2000) 325-337
15. Maas H.J., Danhof M., and Della Pasqua O.E. Prediction of headache response in migraine treatment. Cephalalgia 26 (2006) 416-422
16. Mallinckrodt C.H., Kaiser C.J., Watkin J.G., Molenberghs G., and Carroll R.J. The effect of correlation structure on treatment contrasts estimated from incomplete clinical trial data with likelihood-based repeated measures compared with last observation carried forward ANOVA. Clinical Trials 1 (2004) 477-489
17. Moller H.J. Methodological aspects in the assessment of severity of depression by the Hamilton depression scale. European Archives of Psychiatry and Clinical Neuroscience 251 Suppl. 2 (2001) II13-II20
18. Montgomery S.A. The failure of placebo-controlled studies. ECNP Consensus Meeting, September 13, 1997, Vienna. European College of Neuropsychopharmacology. European Neuropsychopharmacology 9 (1999) 271-276
19. Montgomery S.A., Bech P., Blier P., Moller H.J., Nierenberg A.A., Pinder R.M., et al. Selecting methodologies for the evaluation of differences in time to response between antidepressants. Journal of Clinical Psychiatry 63 (2002) 694-699
20. Rapaport M.H., Schneider L.S., Dunner D.L., Davies J.T., and Pitts C.D. Efficacy of controlled-release paroxetine in the treatment of late-life depression. Journal of Clinical Psychiatry 64 (2003) 1065-1074
21. Santen G, Gomeni R, Danhof M, Della Pasqua O. Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy. Journal of Psychiatric Research; in press. doi:10.1016/j.jpsychires.2007.11.004.
22. Spiegelhalter D.J., Best N.G., Carlin B.R., and van der Linde A. Bayesian measures of model complexity and fit. Journal of the Royal Statistical Society Series B - Statistical Methodology 64 (2002) 583-616
23. Stassen H.H., Delini-Stula A., and Angst J. Time course of improvement under antidepressant treatment: a survival-analytical approach. European Neuropsychopharmacology 3 (1993) 127-135
24. Tai P., Yu E., Cserni G., Vlastos G., Royce M., Kunkler I., et al. Minimum follow-up time required for the estimation of statistical cure of cancer patients: verification using data from 42 cancer sites in the SEER database. BMC Cancer 5 (2005) 48
25. Thase M.E. Methodology to measure onset of action. Journal of Clinical Psychiatry 62 Suppl. 15 (2001) 18-21
26. Thase M.E. Studying new antidepressants: if there were a light at the end of the tunnel, could we see it?. Journal of Clinical Psychiatry 63 Suppl. 2 (2002) 24-28
27. Trivedi M.H., Pigotti T.A., Perera P., Dillingham K.E., Carfagno M.L., and Pitts C.D. Effectiveness of low doses of paroxetine controlled release in the treatment of major depressive disorder. Journal of Clinical Psychiatry 65 (2004) 1356-1364
28. Walsh B.T., Seidman S.N., Sysko R., and Gould M. Placebo response in studies of major depression: variable, substantial, and growing. JAMA 287 (2002) 1840-1847