Trauma-shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal porcine model

Shock

Volumn 30, Issue 2, 2008, Pages 135-141

  Deitch, Edwin A ^a   Senthil, Maheswari ^a   Brown, Margaret ^a   Caputo, Francis ^a   Watkins, Anthony ^a   Anjaria, Devashish ^a   Badami, Chirag ^a   Pisarenko, Vadim ^a   Doucet, Danielle ^a   Lu, Qi ^a   Feketeova, Eleonora ^a   Xu, Da Zhong ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Endothelial injurious activity; Intestinal mucosal injury; Minipig; Neutrophil activation; Sexual dimorphism

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; CASTRATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; HEMODYNAMICS; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; ILEUM MUCOSA; IN VIVO STUDY; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; MESENTERY LYMPH NODE; MINIPIG; NEUTROPHIL; NONHUMAN; SHOCK; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; FEMALE; INJURY; INTESTINE; LYMPH; METABOLISM; ORCHIECTOMY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SWINE;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INTESTINES; LYMPH; MALE; NEUTROPHILS; ORCHIECTOMY; RATS; SHOCK, HEMORRHAGIC; SWINE; SWINE, MINIATURE;

EID: 52149104956     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318161724f     Document Type: Article

References (34)

1. Ananthakrishnan P, Deitch EA: Gut origin sepsis and MODS: the role of sex hormones in modulating intestinal and distant organ injury; a review. XX vs XY 1:108-117, 2003.
2. Angele MK, Wichman M, Eisenmenger S, Schildberg FW, Chaudry IH: Immunologic effects of sex hormones following hemorrhagic shock: potential therapeutic applications; a review. XX vs XY 1:39-45, 2003.
3. Deitch EA, Xu DZ, Lu Q: Gut lymph hypothesis of early shock and trauma-induced multiple organ dysfunction syndrome. A new look at gut origin sepsis. J Org Dysfunct 2:70-79, 2006.
4. Adams CA, Magnotti LJ, Xu DZ, Qu L, Deitch EA: Acute lung injury after hemorrhagic shock is dependent on gut injury and gender. Am Surg 66:905-913, 2003.
5. Sifri ZC, Kaiser VL, Ananthakrishnan P, Wang L, Mohr AM, Hauser CJ, Rameshwar P, Deitch EA, Livingston DH: Bone marrow failure in male rats following trauma/hemorrhagic shock is mediated by mesenteric lymph and modulated by castration. Shock 25:12-16, 2006.
6. Deitch EA, Ananthakrishnan P, Cohen DB, Xu DZ, Feketeova E, Hauser CJ: Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries. Am J Physiol Heart Circ Physiol 291:H1456-H1465, 2006.
7. Morales J, Kibsey P, Thomas PD, Poznansky MJ, Hamilton SM: The effects of ischemia and ischemia-reperfusion on bacterial translocation, lipid peroxidation and gut histology: studies on hemorrhagic shock in pigs. J Trauma 33:221-227, 1992.
8. Von Englehart W: Swine cardiovascular physiology - a review. In: Bustad LK, McLellan RO, eds. Swine in Biomedical Research. Seattle, WA: Frayn; 1966, 307-329.
9. Adams CA, Hauser CJ, Adams JM, Fekete Z, Xu DZ, Sambol JT, Deitch EA: Trauma-hemorrhage-induced neutrophil priming is prevented by mesenteric lymph duct ligation. Shock 18:513-517, 2002.
10. Adams CA, Sambol JT, Xu DZ, Lu Q, Ganger DN, Deitch EA: Hemorrhagic shock-induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption. J Trauma 51:625-632, 2001.
11. Deitch EA, Adams CA, Lu Q, Xu DZ: Mesenteric lymph from rats subjected to trauma-hemorrhagic shock are injurious to rat pulmonary microvascular endothelial cells as well as human umbilical vein endothelial cells. Shock 16:290-293, 2001.
12. Adams JM, Hauser CJ, Adams CA, Xu DZ, Livingston DH, Deitch EA: Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. Crit Care Med 29:2194-2198, 2001.
13. Deitch EA, Adams CA, Lu Q, Xu DZ: A time course study of the protective effects of mesenteric lymph duct ligation on hemorrhagic shock-induced pulmonary injury and the toxic effects of lymph from shocked rats on endothelial cell monolayer permeability. Surgery 129:39-47, 2001.
14. Deitch EA, Shi HP, Lu Q, Feketeova E, Skurnick J, Xu DZ: Mesenteric lymph from burned rats induces endothelial cell injury and activates neutrophils. Crit Care Med 32:533-538, 2004.
15. Deitch EA, Xu DZ, Nahrun MB, Deitch DC, Lu Qi, Marino AA: Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg 221:299-307, 1995.
16. Xu DZ, Lu Qi, Deitch EA: Nitric oxide directly impairs intestinal barrier function. Shock 17:139-145, 2002.
17. Deitch EA, Winterton J, Li M, Berg RD: The gut as a portal of entry for bacteremia. Role of protein malnutrition. Ann Surg 205:681-692, 1987.
18. Senthil M, Brown M, Xu DZ, Lu Q, Keketeova E, Deitch EA: Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple organ dysfunction syndrome: validating studies in a porcine model. J Trauma 60:958-967, 2006.
19. Deitch EA, Livingston DH, Lavery RF, Monaghan SF, Bongu A, Macheido GW: Hormonally active females tolerate shock-trauma better than males: A prospective study of over 4000 trauma patients. Ann Surg 246:453-455, 2007.
20. McKinley BA, Kozar RA, Cocanour CS, Valdivia A, Sailors RM, Ware DN, Moore FA: Standardized trauma resuscitation; female hearts respond better. Arch Surg 137:578-584, 2002.
21. Powell DW: Barrier function of epithelia. Am J Physiol 241:G241-G288, 1981.
22. Laughlin JM, Welshons WV, Sturek M, Rush JWE, Turk JR, Taylor JA, Judy BM, Henderson KK, Ganjam VK: Gender, exercise training and eNOS expression in porcine skeletal muscle arteries. J Appl Physiol 95:250-264, 2003.
23. Deitch EA, Chu H, Xu DZ: Organ blood flow and the central hemodynamic response is better preserved in female, as opposed to male rats, after trauma-hemorrhagic shock. J Trauma. In press.
24. Ba ZF, Kuebler JF, Rue LW, Bland KI, Wang P, Chaudry IH: Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function. Am J Physiol Heart Circ Physiol 284:H21262-H21269, 2003.
25. Deitch EA, Feketeova E, Lu Q, Zaets S, Berezina TL, Machiedo GW, Hauser CJ, Livingston DH, Xu DZ: Resistance of the female, as opposed to the male intestine to I/R-mediated injury is associated with increased resistance to gut-induced distant organ injury. Shock 29:78-83, 2008.
26. Homma H, Xu DZ, Deitch EA, et al.: The female intestine is more resistant than the male intestine to gut injury and inflammation when subjected to conditions associated with shock states. Am J Physiol Gastrointest Liver Physiol 288:G466-G472, 2005.
27. Mendelsohn ME, Karas RH: The protective effects of estrogen on the cardiovascular system. New Engl J Med 340:1801-1811, 1999.
28. Toth B, Yokoyama Y, Kuebler JF, Schwacha MG, Rue LW, Bland KI, Chaudry IH: Sex differences in hepatic heme oxygenase expression and activity following trauma and hemorrhagic shock. Arch Surg 138:1375-1382, 2003.
29. Zhang Y, Davidge ST: Effect of estrogen replacement on vasoconstrictor responses in rat mesenteric arteries. Hypertension 34:1117-1122, 1992.
30. Dubney RK, Jackson EK, Keller PJ, Imthurn B, Rosselli M: Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism. Hypertension 37:640-644, 2001.
31. Davidge ST, Zhang Y: Estrogen replacement suppresses a prostaglandin H synthase-dependent vasoconstrictor in rat mesenteric arteries. Circ Res 83:388-395, 1998.
32. Remmers DE, Wang P, Cioffi WG, Chaudry IH: Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. Am J Physiol 273:H2919-H2925, 1997.
33. Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV: Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Am J Physiol 267:H887-H893, 1994.
34. Chen YF, Naftilan AJ, Oparil S: Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats. Hypertension 19:456-463, 1992.