CYP2D6 genotyping and the pharmacogenetics of tamoxifen

Clinical Advances in Hematology and Oncology

Volumn 6, Issue 7, 2008, Pages 493-494

  Flockhart, David ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANASTROZOLE; AROMATASE INHIBITOR; CYTOCHROME P450 2D6; ESTROGEN RECEPTOR; EXEMESTANE; LETROZOLE; RALOXIFENE; TAMOXIFEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

ADJUVANT THERAPY; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER RISK; DEEP VEIN THROMBOSIS; DRUG CHOICE; DRUG EFFICACY; DRUG METABOLISM; DRUG SAFETY; GENOTYPE; HIGH RISK PATIENT; HOT FLUSH; HUMAN; MEDICAL DECISION MAKING; OSTEOPOROSIS; PAIN; PATIENT SELECTION; PHARMACOGENETICS; POSTMENOPAUSE; PREMENOPAUSE; RECURRENCE RISK; RISK BENEFIT ANALYSIS; RISK REDUCTION; BREAST TUMOR; ENZYMOLOGY; FEMALE; GENETICS; METHODOLOGY; REVIEW;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CYTOCHROME P-450 CYP2D6; FEMALE; GENOTYPE; HUMANS; PHARMACOGENETICS; TAMOXIFEN;

EID: 52149103806     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Desta Z, Flockhart DA. Germline pharmacogenetics of tamoxifen response: have we teamed enough? J Clin Oncol. 2007;25:5147-5149.
2. Hayes DF, Stearns V, Rae J, Flockhart D; Consortium on Breast Cancer Pharmacogenomics. A model citizen? Is tamoxifen more effective than aromarase inhibitors if we pick the right patients? J Natl Cancer Inst. 2008;100:610-613.
3. Ingle JN. Pharmacogenomics of tamoxifen and aromatase inhibitors. Cancer. 2008;112(3 suppl):695-699.
4. Schroth W, Antoniadou L, Fritz P, et al. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol. 2007;25:5187-5193.
5. Punglia RS, Burstein HJ, Winer EP, Weeks JC. Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for post menopausal breast cancer: a modeling analysis. J Natl Cancer Inst. 2008;100: 642-648.