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Volumn 25, Issue 33, 2007, Pages 5147-5149

Germline pharmacogenetics of tamoxifen response: Have we learned enough?

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; BISPHOSPHONIC ACID DERIVATIVE; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; DRUG METABOLITE; ENDOXIFEN; NORTAMOXIFEN; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 36849092797     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2007.13.4957     Document Type: Editorial
Times cited : (24)

References (22)
  • 1
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med 339:1609-1618, 1998
    • (1998) N Engl J Med , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 2
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials - Early Breast Cancer Trialists' Collaborative Group
    • Tamoxifen for early breast cancer: An overview of the randomised trials - Early Breast Cancer Trialists' Collaborative Group. Lancet 351:1451-1467, 1998
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 4
    • 36349024762 scopus 로고    scopus 로고
    • Breast cancer treatment outcome with adjuvant tamoxifen in relation to patient CYP2D6 and CYP2C19 genotypes
    • Schroth W, Antoniadou L, Fritz P, et al: Breast cancer treatment outcome with adjuvant tamoxifen in relation to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25:5187-5193, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 5187-5193
    • Schroth, W.1    Antoniadou, L.2    Fritz, P.3
  • 5
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity
    • Jordan VC, Collins MM, Rowsby L, et al: A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity. J Endocrinol 75:305-316, 1977
    • (1977) J Endocrinol , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3
  • 6
    • 0020402019 scopus 로고
    • Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance
    • Jordan VC: Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance. Breast Cancer Res Treat 2:123-138, 1982
    • (1982) Breast Cancer Res Treat , vol.2 , pp. 123-138
    • Jordan, V.C.1
  • 7
    • 0020033521 scopus 로고
    • Tamoxifen antiestrogens: A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen
    • Robertson DW, Katzenellenbogen JA, Long DJ, et al: Tamoxifen antiestrogens: A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. J Steroid Biochem 16:1-13, 1982
    • (1982) J Steroid Biochem , vol.16 , pp. 1-13
    • Robertson, D.W.1    Katzenellenbogen, J.A.2    Long, D.J.3
  • 8
    • 0020003085 scopus 로고
    • Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth
    • Coezy E, Borgna JL, Rochefort H: Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth. Cancer Res 42:317-323, 1982
    • (1982) Cancer Res , vol.42 , pp. 317-323
    • Coezy, E.1    Borgna, J.L.2    Rochefort, H.3
  • 9
    • 0346602691 scopus 로고    scopus 로고
    • Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    • Stearns V, Johnson MD, Rae JM, et al: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95:1758-1764, 2003
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1758-1764
    • Stearns, V.1    Johnson, M.D.2    Rae, J.M.3
  • 10
    • 3342932419 scopus 로고    scopus 로고
    • Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
    • Johnson MD, Zuo H, Lee KH, et al: Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res Treat 85:151-159, 2004
    • (2004) Breast Cancer Res Treat , vol.85 , pp. 151-159
    • Johnson, M.D.1    Zuo, H.2    Lee, K.H.3
  • 11
    • 0023922814 scopus 로고
    • Identification of 4-hydroxy-Ndesmethyltamoxifen as a metabolite of tamoxifen in human bile
    • Lien EA, Solheim E, Kvinnsland S, et al: Identification of 4-hydroxy-Ndesmethyltamoxifen as a metabolite of tamoxifen in human bile. Cancer Res 48:2304-2308, 1988
    • (1988) Cancer Res , vol.48 , pp. 2304-2308
    • Lien, E.A.1    Solheim, E.2    Kvinnsland, S.3
  • 12
    • 17644387537 scopus 로고    scopus 로고
    • Endoxifen (4-hydroxy-N- desmethyltamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
    • Lim YC, Desta Z, Flockhart DA, et al: Endoxifen (4-hydroxy-N- desmethyltamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 55:471-478, 2005
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 471-478
    • Lim, Y.C.1    Desta, Z.2    Flockhart, D.A.3
  • 13
    • 33745939124 scopus 로고    scopus 로고
    • Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells
    • Lim YC, Li L, Desta Z, et al: Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther 318:503-512, 2006
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 503-512
    • Lim, Y.C.1    Li, L.2    Desta, Z.3
  • 14
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
    • Desta Z, Ward BA, Soukhova NV, et al: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310:1062-1075, 2004
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3
  • 15
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Jin Y, Desta Z, Stearns V, et al: CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97:30-39, 2005
    • (2005) J Natl Cancer Inst , vol.97 , pp. 30-39
    • Jin, Y.1    Desta, Z.2    Stearns, V.3
  • 16
    • 33745347897 scopus 로고    scopus 로고
    • Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
    • Borges S, Desta Z, Li L, et al: Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80:61-74, 2006
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 61-74
    • Borges, S.1    Desta, Z.2    Li, L.3
  • 17
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al: Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23:9312-9318, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 18
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    • Goetz MP, Knox SK, Suman VJ, et al: The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 101:113-121, 2007
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 113-121
    • Goetz, M.P.1    Knox, S.K.2    Suman, V.J.3
  • 19
    • 21344467511 scopus 로고    scopus 로고
    • Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    • Nowell SA, Ahn J, Rae JM, et al: Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91:249-258, 2005
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 249-258
    • Nowell, S.A.1    Ahn, J.2    Rae, J.M.3
  • 20
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • Wegman P, Vainikka L, Stål O, et al: Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res 7:R284-R290, 2005
    • (2005) Breast Cancer Res , vol.7
    • Wegman, P.1    Vainikka, L.2    Stål, O.3
  • 21
    • 34548532227 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
    • Lim H-S, Lee HJ, Lee ES, et al: Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 25:3837-3845, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 3837-3845
    • Lim, H.-S.1    Lee, H.J.2    Lee, E.S.3
  • 22
    • 33747045564 scopus 로고    scopus 로고
    • Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxen Trial
    • Bonanni B, Macis D, Maisonneuve P, et al: Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxen Trial. J Clin Oncol 24:3708-3709, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 3708-3709
    • Bonanni, B.1    Macis, D.2    Maisonneuve, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.