-
1
-
-
0032569831
-
Tamoxifen in the treatment of breast cancer
-
Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med 339:1609-1618, 1998
-
(1998)
N Engl J Med
, vol.339
, pp. 1609-1618
-
-
Osborne, C.K.1
-
2
-
-
0032537396
-
Tamoxifen for early breast cancer: An overview of the randomised trials - Early Breast Cancer Trialists' Collaborative Group
-
Tamoxifen for early breast cancer: An overview of the randomised trials - Early Breast Cancer Trialists' Collaborative Group. Lancet 351:1451-1467, 1998
-
(1998)
Lancet
, vol.351
, pp. 1451-1467
-
-
-
4
-
-
36349024762
-
Breast cancer treatment outcome with adjuvant tamoxifen in relation to patient CYP2D6 and CYP2C19 genotypes
-
Schroth W, Antoniadou L, Fritz P, et al: Breast cancer treatment outcome with adjuvant tamoxifen in relation to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25:5187-5193, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 5187-5193
-
-
Schroth, W.1
Antoniadou, L.2
Fritz, P.3
-
5
-
-
0017665570
-
A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity
-
Jordan VC, Collins MM, Rowsby L, et al: A monohydroxylated metabolite of tamoxifen with potent antiestrogenic activity. J Endocrinol 75:305-316, 1977
-
(1977)
J Endocrinol
, vol.75
, pp. 305-316
-
-
Jordan, V.C.1
Collins, M.M.2
Rowsby, L.3
-
6
-
-
0020402019
-
Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance
-
Jordan VC: Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance. Breast Cancer Res Treat 2:123-138, 1982
-
(1982)
Breast Cancer Res Treat
, vol.2
, pp. 123-138
-
-
Jordan, V.C.1
-
7
-
-
0020033521
-
Tamoxifen antiestrogens: A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen
-
Robertson DW, Katzenellenbogen JA, Long DJ, et al: Tamoxifen antiestrogens: A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. J Steroid Biochem 16:1-13, 1982
-
(1982)
J Steroid Biochem
, vol.16
, pp. 1-13
-
-
Robertson, D.W.1
Katzenellenbogen, J.A.2
Long, D.J.3
-
8
-
-
0020003085
-
Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth
-
Coezy E, Borgna JL, Rochefort H: Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth. Cancer Res 42:317-323, 1982
-
(1982)
Cancer Res
, vol.42
, pp. 317-323
-
-
Coezy, E.1
Borgna, J.L.2
Rochefort, H.3
-
9
-
-
0346602691
-
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
-
Stearns V, Johnson MD, Rae JM, et al: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95:1758-1764, 2003
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1758-1764
-
-
Stearns, V.1
Johnson, M.D.2
Rae, J.M.3
-
10
-
-
3342932419
-
Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
-
Johnson MD, Zuo H, Lee KH, et al: Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res Treat 85:151-159, 2004
-
(2004)
Breast Cancer Res Treat
, vol.85
, pp. 151-159
-
-
Johnson, M.D.1
Zuo, H.2
Lee, K.H.3
-
11
-
-
0023922814
-
Identification of 4-hydroxy-Ndesmethyltamoxifen as a metabolite of tamoxifen in human bile
-
Lien EA, Solheim E, Kvinnsland S, et al: Identification of 4-hydroxy-Ndesmethyltamoxifen as a metabolite of tamoxifen in human bile. Cancer Res 48:2304-2308, 1988
-
(1988)
Cancer Res
, vol.48
, pp. 2304-2308
-
-
Lien, E.A.1
Solheim, E.2
Kvinnsland, S.3
-
12
-
-
17644387537
-
Endoxifen (4-hydroxy-N- desmethyltamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
-
Lim YC, Desta Z, Flockhart DA, et al: Endoxifen (4-hydroxy-N- desmethyltamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 55:471-478, 2005
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 471-478
-
-
Lim, Y.C.1
Desta, Z.2
Flockhart, D.A.3
-
13
-
-
33745939124
-
Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells
-
Lim YC, Li L, Desta Z, et al: Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther 318:503-512, 2006
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 503-512
-
-
Lim, Y.C.1
Li, L.2
Desta, Z.3
-
14
-
-
4243063941
-
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
-
Desta Z, Ward BA, Soukhova NV, et al: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310:1062-1075, 2004
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 1062-1075
-
-
Desta, Z.1
Ward, B.A.2
Soukhova, N.V.3
-
15
-
-
19944434201
-
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
-
Jin Y, Desta Z, Stearns V, et al: CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97:30-39, 2005
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 30-39
-
-
Jin, Y.1
Desta, Z.2
Stearns, V.3
-
16
-
-
33745347897
-
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
-
Borges S, Desta Z, Li L, et al: Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80:61-74, 2006
-
(2006)
Clin Pharmacol Ther
, vol.80
, pp. 61-74
-
-
Borges, S.1
Desta, Z.2
Li, L.3
-
17
-
-
33644639136
-
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
-
Goetz MP, Rae JM, Suman VJ, et al: Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23:9312-9318, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 9312-9318
-
-
Goetz, M.P.1
Rae, J.M.2
Suman, V.J.3
-
18
-
-
33847034287
-
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
-
Goetz MP, Knox SK, Suman VJ, et al: The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 101:113-121, 2007
-
(2007)
Breast Cancer Res Treat
, vol.101
, pp. 113-121
-
-
Goetz, M.P.1
Knox, S.K.2
Suman, V.J.3
-
19
-
-
21344467511
-
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
-
Nowell SA, Ahn J, Rae JM, et al: Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91:249-258, 2005
-
(2005)
Breast Cancer Res Treat
, vol.91
, pp. 249-258
-
-
Nowell, S.A.1
Ahn, J.2
Rae, J.M.3
-
20
-
-
29144491089
-
Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
-
Wegman P, Vainikka L, Stål O, et al: Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res 7:R284-R290, 2005
-
(2005)
Breast Cancer Res
, vol.7
-
-
Wegman, P.1
Vainikka, L.2
Stål, O.3
-
21
-
-
34548532227
-
Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
-
Lim H-S, Lee HJ, Lee ES, et al: Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 25:3837-3845, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 3837-3845
-
-
Lim, H.-S.1
Lee, H.J.2
Lee, E.S.3
-
22
-
-
33747045564
-
Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxen Trial
-
Bonanni B, Macis D, Maisonneuve P, et al: Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxen Trial. J Clin Oncol 24:3708-3709, 2006
-
(2006)
J Clin Oncol
, vol.24
, pp. 3708-3709
-
-
Bonanni, B.1
Macis, D.2
Maisonneuve, P.3
|