Decline of serum HBV DNA and no change apportioned by the same hepatic parenchyma cell volume from hepatic fibrosis stage 1 to stage 4 during the natural history of chronic hepatitis B

Intervirology

Volumn 51, Issue 4, 2008, Pages 235-240

  Ke, Wei Min ^a   Xie, Shi Bin ^a   Yu, Li Na ^a   Liu, Ting ^a   Lai, Jing ^a   He, Da Qiu ^a   Li, Xiao He ^a   Gao, Zhi Liang ^a   Ke, Ying ^b   Chen, Pei Jia ^c  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c Response Genetics Inc   (United States)

Author keywords

HBV DNA dynamics; Hepatic fibrosis stage; Hepatic parenchyma cell volume; Natural history of chronic hepatitis B

Indexed keywords

VIRUS DNA;

ADULT; ARTICLE; BLOOD LEVEL; CELL VOLUME; CHRONIC HEPATITIS; DISEASE COURSE; DISEASE SEVERITY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; LIVER FIBROSIS; LIVER PARENCHYMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; VIRAL LOAD;

HEPATITIS B VIRUS;

EID: 52149086559     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000156482     Document Type: Article

References (29)

1. Hou J, Liu Z, Gu F: Epidemiology and prevention of hepatitis B virus infection. Int J Med Sci 2005;2:50-57.
2. Lavanchy D: Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004;11:97-107.
3. Marcellin P, Castelnau C, Martinot-Peignoux M, Boyer N: Natural history of hepatitis B. Minerva Gastroenterol Dietol 2005;51:63-75.
4. Lee A, Cheng FF, Chan CS, Lau LC, Lo AS: Sero-epidemiology and risk factors of positive hepatitis B surface antigen amongst Chinese adolescents. Asia Pac J Public Health 2001;13:30-35.
5. Lok AS, Heathcote EJ, Hoofnagle JH: Management of hepatitis B: 2000 - summary of a workshop. Gastroenterology 2001;120:1828-1853.
6. Kumar M, Jain S, Sharma BC, Sarin SK: Differentiating acute hepatitis B from the first episode of symptomatic exacerbation of chronic hepatitis B. Dig Dis Sci 2006;51:594-599.
7. Huang YH, Wu JC, Chang TT, Sheen IJ, Huo TI, Lee PC, Su CW, Lee SD: Association of core promoter/precore mutations and viral load in e antigen-negative chronic hepatitis B patients. J Viral Hepat 2006;13:336-342.
8. Zhao H, Tian GS: Differential clinical diagnostic parameters of acute hepatitis B and flare of chronic HBV infection. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2004;18:363-365.
9. Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ; Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer - In HBV (the REVEAL-HBV) Study Group: Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006;130:678-686.
10. Yuen MF, Sablon E, Hui CK, Li TM, Yuan HJ, Wong DK, Doutreloigne J, Bogaerts V, Wong BC, Fan ST, Lai CL: Prognostic factors in severe exacerbation of chronic hepatitis B. Clin Infect Dis 2003;36:979-984.
11. Schacherer D, Schuh C, Strauch U, Ehrenstein B, Wiest R, Schölmerich J, Schlottmann K, Klebl F: Improvement in the routine diagnostic assessment of the liver by high-resolution sonography: an analysis of 999 cases. Scand J Gastroenterol 2007;42:366-373.
12. Kawaoka T, Suzuki F, Akuta N, Suzuki Y, Arase Y, Sezaki H, Kawamura Y, Hosaka T, Kobayashi M, Ikeda K, Kumada H: Efficacy of lamivudine therapy in elderly patients with chronic hepatitis B infection. J Gastroenterol 2007;42:395-401.
13. Wang CC, Liu CJ, Lai MY, Kao JH, Chen DS: Dynamics of hepatitis B e antigen index ratio correlate with treatment response in chronic hepatitis B patients. Liver Int 2007;27:235-239.
14. Dai CY, Chuang WL, Hsieh MY, Lee LP, Huang JF, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Tsai JF, Chang WY, Yu ML: Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B. Antiviral Res 2007;75:146-151.
15. Wong DK, Yuen MF, Ngai VW, Fung J, Lai CL: One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels. Antivir Ther 2006;11:909-916.
16. Jia JD, Hou JL, Yin YK, Xu DZ, Tan DM, Niu JQ, Zhou XQ, Wang YM, Zhu LM, He YW, Ren H, Wan MB, Chen CW, Wu SM, Chen YG, Xu JZ, Wang QH, Wei L, Ma H: The degree of HBV suppression with 24-week telbivudine-or lamivudine-treatment in hepatitis B patients predicts the efficacy of the treatment at week 52. Zhonghua Gan Zang Bing Za Zhi 2007;15:342-345.
17. 2b therapy. Gut 2005;54:1604-1609.
18. 1 therapy for chronic hepatitis B patients. Intern Med 2003;42:941-946.
19. Van Nunen AB, Pontesilli O, Uytdehaag F, Osterhaus AD, de Man RA: Suppression of hepatitis B virus replication mediated by hepatitis A-induced cytokine production. Liver 2001;21:45-49.
20. Chu CM, Sheen IS, Liaw YF: Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection. Scand J Gastroenterol 2004;39:778-782.
21. Zhang GS, Feng FM, Li YL, Yuan JX, Shang H: A study of chronic hepatitis B infection superinfected with hepatitis E infection. Zhonghua Gan Zang Bing Za Zhi 2006;14:906-908.
22. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ: Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994;19:1513-1520.
23. Xie SB, Yao JL, Zheng SS, Yao CL, Zheng RQ: The levels of serum fibrosis marks and morphometric quantitative measurement of hepatic fibrosis. Hepatobiliary Pancreat Dis Int 2002;1:202-206.
24. Núñez M, García-Samaniego J, Soriano V: Advances in the diagnosis and treatment of the infection by the hepatitis B virus (in Spanish). Enferm Infecc Microbiol Clin 2004;22:539-549.
25. Hoofnagle JH, Doo E, Liang TJ, Fleischer R, Lok AS: Management of hepatitis B: summary of a clinical research workshop. Hepatology 2007;45:1056-1075.
26. Bédossa P, Paradis V: Regression of hepatic fibrosis physiopathological aspects and clinical reality. Presse Med 2003;32:704-710.
27. Fotiadu A, Tzioufa V, Vrettou E, Koufogiannis D, Papadimitriou CS, Hytiroglou P: Progenitor cell activation in chronic viral hepatitis. Liver Int 2004;24:268-274.
28. Shen L, Li JQ, Zeng MD, Fan ST, Lu LG, Bao H, Cao AP: Evaluation of the value of ultrasonography in diagnosis of liver fibrosis in patients with chronic viral hepatitis. Zhonghua Gan Zang Bing Za Zhi 2005;13:117-120.
29. Kim TH, Kim YS, Yeom JJ, Cho EY, Kim HS, Kim HC, Park DS, Cho JH, Yoon GJ, Moon HB: Relevancy between liver injury, serum HBV-DNA, and intrahepatic HBcAg in young male chronic HBV carriers. Korean J Gastroenterol 2004;44:84-92.