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Volumn 52, Issue 5, 2008, Pages 861-871

Growth hormone deficiency in adulthood: How to diagnose and when to treat?;Deficiência de GH na vida adulta: Como diagnosticar e quando tratar?

Author keywords

Adult growth hormone deficiency; GH; Growth hormone deficiency; hRGH replacement therapy; Hypopituitarism

Indexed keywords


EID: 52149085643     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/s0004-27302008000500019     Document Type: Review
Times cited : (2)

References (36)
  • 1
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990;336:285-8.
    • (1990) Lancet , vol.336 , pp. 285-288
    • Rosen, T.1    Bengtsson, B.A.2
  • 4
    • 3242712491 scopus 로고    scopus 로고
    • Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy
    • Svensson J, Bengtsson B-Å, Rosén T, Odén A, Johannsson G. Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy. J Clin Endocrinol Metab Svensson. 2004;89(7):3306-12.
    • (2004) J Clin Endocrinol Metab Svensson , vol.89 , Issue.7 , pp. 3306-3312
    • Svensson, J.1    Bengtsson, B.-Å.2    Rosén, T.3    Odén, A.4    Johannsson, G.5
  • 5
    • 0034890263 scopus 로고    scopus 로고
    • Optimising GH therapy in adults and children. Review. KIMS Study Group and the KIMS International Board. Pharmacia and Upjohn International Metabolic Database
    • Drake WM, Howell SJ, Monson JP, Shalet SM. Optimising GH therapy in adults and children. Review. KIMS Study Group and the KIMS International Board. Pharmacia and Upjohn International Metabolic Database. Endocr Rev. 2001;22:425-50.
    • (2001) Endocr Rev , vol.22 , pp. 425-450
    • Drake, W.M.1    Howell, S.J.2    Monson, J.P.3    Shalet, S.M.4
  • 6
    • 0031792510 scopus 로고    scopus 로고
    • consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the Growth Hormone Research Society (GHRS) workshop on adult growth hormone deficiency
    • GHRS
    • GHRS: consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society (GHRS) workshop on adult growth hormone deficiency. J Clin Endocrinol Metab. 1998;83: 379-81.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 379-381
  • 7
    • 38349050260 scopus 로고    scopus 로고
    • Ho on behalf of the 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II
    • Ken KY. Ho on behalf of the 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol. 2007;157(6):695-700.
    • (2007) Eur J Endocrinol , vol.157 , Issue.6 , pp. 695-700
    • Ken, K.Y.1
  • 9
    • 35948943202 scopus 로고    scopus 로고
    • The management of growth hormone deficiency in adults
    • Nilsson A, Svensson J, Johannsson G. The management of growth hormone deficiency in adults. Growth Horm IGF Res. 2007;17:441-62.
    • (2007) Growth Horm IGF Res , vol.17 , pp. 441-462
    • Nilsson, A.1    Svensson, J.2    Johannsson, G.3
  • 13
    • 0028047982 scopus 로고
    • The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism
    • Toogood AA, Beardwell CG, Shalet SM. The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clin Endocrinol (Oxf).1994;41:511-6.
    • (1994) Clin Endocrinol (Oxf) , vol.41 , pp. 511-516
    • Toogood, A.A.1    Beardwell, C.G.2    Shalet, S.M.3
  • 14
    • 0036169179 scopus 로고    scopus 로고
    • Hartman ML, Crowe BJ, Biller BMK, Ho KKY, Clemmons DR, Chipman JJ on behalf of the HypoCCS Advisory Board and the U.S. HypoCCS Study Group. Which Patients do not require a GH stimulation test for the diagnosis of adult GH deficiency? J Clin Endocrinol Metab. 2002;87(2):477-85.
    • Hartman ML, Crowe BJ, Biller BMK, Ho KKY, Clemmons DR, Chipman JJ on behalf of the HypoCCS Advisory Board and the U.S. HypoCCS Study Group. Which Patients do not require a GH stimulation test for the diagnosis of adult GH deficiency? J Clin Endocrinol Metab. 2002;87(2):477-85.
  • 15
    • 0029098607 scopus 로고
    • Which adults develop side-effects of growth hormone replacement?
    • Holmes SJ, Shalet SM. Which adults develop side-effects of growth hormone replacement? Clin. Endocrinol (Oxf). 1995;43:143-9.
    • (1995) Clin. Endocrinol (Oxf , vol.43 , pp. 143-149
    • Holmes, S.J.1    Shalet, S.M.2
  • 17
    • 8044255242 scopus 로고    scopus 로고
    • Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment
    • Attanasio AF, Lamberts SWJ, Matranga AMC, Birkett MA, Bates PC, Valk NK, et al. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. J Clin Endocrinol Metab. 1997;82(1):82-8.
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.1 , pp. 82-88
    • Attanasio, A.F.1    Lamberts, S.W.J.2    Matranga, A.M.C.3    Birkett, M.A.4    Bates, P.C.5    Valk, N.K.6
  • 18
    • 0025787687 scopus 로고
    • Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men
    • Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 1991;73:1081-8.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1081-1088
    • Iranmanesh, A.1    Lizarralde, G.2    Veldhuis, J.D.3
  • 19
    • 23044510438 scopus 로고    scopus 로고
    • Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men
    • Johannsson G, Gibney J, Wolthers T, Leung KC, Ho KKY. Independent and combined effects of testosterone and growth hormone on extracellular water in hypopituitary men. J Clin Endocrinol Metab. 2005;90(7):3989-94.
    • (2005) J Clin Endocrinol Metab , vol.90 , Issue.7 , pp. 3989-3994
    • Johannsson, G.1    Gibney, J.2    Wolthers, T.3    Leung, K.C.4    Ho, K.K.Y.5
  • 20
    • 0029922124 scopus 로고    scopus 로고
    • The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender
    • Johannsson G, Bjarnason R, Bramnert M, Carlsson LM, Degerblad M, Manhem P, et al. The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age, and gender. J Clin Endocrinol Metab. 1996;81:1575-81.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1575-1581
    • Johannsson, G.1    Bjarnason, R.2    Bramnert, M.3    Carlsson, L.M.4    Degerblad, M.5    Manhem, P.6
  • 21
    • 0030663542 scopus 로고    scopus 로고
    • Metabolic effects and pharmacokinetics of a growth hormone pulse in healthy adults: Relation to age, sex, and body composition
    • Vahl N, Moller N, Lauritzen T, Christiansen JS, Jorgensen JOL. Metabolic effects and pharmacokinetics of a growth hormone pulse in healthy adults: relation to age, sex, and body composition. J Clin Endocrinol Metab. 1997;82:1-7.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1-7
    • Vahl, N.1    Moller, N.2    Lauritzen, T.3    Christiansen, J.S.4    Jorgensen, J.O.L.5
  • 22
    • 0025882208 scopus 로고
    • Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insuline-like growth factor I, and GH-binding protein in postmenopausal women
    • Weissberger AJ, Ho KKY, Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insuline-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab. 1991;72:374-81.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 374-381
    • Weissberger, A.J.1    Ho, K.K.Y.2    Lazarus, L.3
  • 23
    • 0027434964 scopus 로고
    • Effects of different oral oestrogen formulations on insuline-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women
    • Kelly JJ, Rajkovic IA, O'Sullivan AJ, et al. Effects of different oral oestrogen formulations on insuline-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol (Oxf). 1993;39:561-7.
    • (1993) Clin Endocrinol (Oxf) , vol.39 , pp. 561-567
    • Kelly, J.J.1    Rajkovic, I.A.2    O'Sullivan, A.J.3
  • 24
    • 1942440983 scopus 로고    scopus 로고
    • Adults with partial growth hormone deficiency have an adverse body composition
    • Murray RD, Adams JE, Shalet SM. Adults with partial growth hormone deficiency have an adverse body composition. J Clin Endocrinol Metab. 2004;89(4):1586-91.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.4 , pp. 1586-1591
    • Murray, R.D.1    Adams, J.E.2    Shalet, S.M.3
  • 25
    • 0029879525 scopus 로고    scopus 로고
    • Comparison of methods to estimate body fat in growth hormone deficient adults
    • Bosaeus I, Johannsson G, Rosén T, et al. Comparison of methods to estimate body fat in growth hormone deficient adults. Clin Endocrinol (Oxf). 1996;44:395-402.
    • (1996) Clin Endocrinol (Oxf) , vol.44 , pp. 395-402
    • Bosaeus, I.1    Johannsson, G.2    Rosén, T.3
  • 26
    • 0842309243 scopus 로고    scopus 로고
    • Growth hormone replacement in adults and bone mineral density: A systematic review and meta-analysis
    • Davidson P, Milne R, Chase D, Cooper C. Growth hormone replacement in adults and bone mineral density: a systematic review and meta-analysis. Clin Endocrinol (Oxf). 2004;60:92-8.
    • (2004) Clin Endocrinol (Oxf) , vol.60 , pp. 92-98
    • Davidson, P.1    Milne, R.2    Chase, D.3    Cooper, C.4
  • 27
    • 2442692724 scopus 로고    scopus 로고
    • Long-term skeletal effects of recombinant human growth hormone (hrGH) alone and hrGH combined with alendronate in GH-deficient adults: A seven-year follow-up study
    • Biermasz NR, Hamdy NA, Pereira AM, Romijn JA, Roelfsema F. Long-term skeletal effects of recombinant human growth hormone (hrGH) alone and hrGH combined with alendronate in GH-deficient adults: a seven-year follow-up study. Clin Endocrinol (Oxf). 2004;60:568-75.
    • (2004) Clin Endocrinol (Oxf) , vol.60 , pp. 568-575
    • Biermasz, N.R.1    Hamdy, N.A.2    Pereira, A.M.3    Romijn, J.A.4    Roelfsema, F.5
  • 28
    • 0036979609 scopus 로고    scopus 로고
    • van der Sluis I, Boot AM, Hop WC, De Rijke YB, Krenning EP, de Muinck Keizer-Schrama SM. Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study. Horm Res. 2002;58:207-14.
    • van der Sluis I, Boot AM, Hop WC, De Rijke YB, Krenning EP, de Muinck Keizer-Schrama SM. Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study. Horm Res. 2002;58:207-14.
  • 29
    • 2442526224 scopus 로고    scopus 로고
    • Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: A metaanalysis of blinded, randomized, placebo-controlled trials
    • Maison P, Griffin S, Nicoue-Beglah M, Haddad N, Balkau B, Chanson P. Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a metaanalysis of blinded, randomized, placebo-controlled trials. J Clin Endocrinol Metab. 2004;89(5):2192-9.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.5 , pp. 2192-2199
    • Maison, P.1    Griffin, S.2    Nicoue-Beglah, M.3    Haddad, N.4    Balkau, B.5    Chanson, P.6
  • 30
    • 0037835948 scopus 로고    scopus 로고
    • Effects of growth hormone replacemnet therapy on metabolic and cardiac parameters, in adult with childhood-onset growth hormone deficiency
    • Jallad RS, Liberman B, Vianna CB, Vieira ML, Ramires JA, Knoepfelmacher M. Effects of growth hormone replacemnet therapy on metabolic and cardiac parameters, in adult with childhood-onset growth hormone deficiency. Growth Hormon IGF Res. 2003;13(2-3):81-8.
    • (2003) Growth Hormon IGF Res , vol.13 , Issue.2-3 , pp. 81-88
    • Jallad, R.S.1    Liberman, B.2    Vianna, C.B.3    Vieira, M.L.4    Ramires, J.A.5    Knoepfelmacher, M.6
  • 31
    • 0037548298 scopus 로고
    • Treatment of a pituitary dwarf with human growth hormone
    • Raben MS. Treatment of a pituitary dwarf with human growth hormone. J Clin Endocrinol. 1958;18:901-3.
    • (1958) J Clin Endocrinol , vol.18 , pp. 901-903
    • Raben, M.S.1
  • 32
    • 13544256539 scopus 로고    scopus 로고
    • The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: A meta-analysis
    • Arwert LI, Deijen JB, Witlox J, Drent ML. The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: a meta-analysis. Growth Horm IGF Res. 2005;15(1):47-54.
    • (2005) Growth Horm IGF Res , vol.15 , Issue.1 , pp. 47-54
    • Arwert, L.I.1    Deijen, J.B.2    Witlox, J.3    Drent, M.L.4
  • 33
    • 0033061558 scopus 로고    scopus 로고
    • Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: A placebo-controlled trial
    • Soares CN, Musolino NR, Cunha Neto M, Caires MA, Rosenthal MC, Camargo CP, et al. Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo-controlled trial. Arq Neuropsiquiatr. 1999; 57(2A):182-9.
    • (1999) Arq Neuropsiquiatr , vol.57 , Issue.2 A , pp. 182-189
    • Soares, C.N.1    Musolino, N.R.2    Cunha Neto, M.3    Caires, M.A.4    Rosenthal, M.C.5    Camargo, C.P.6
  • 34
    • 37449004445 scopus 로고    scopus 로고
    • Growth hormone (GH) replacement in hypopituitary adults with GH deficiency evaluated by a utility-weighted quality of life index: A precursor to cost-utility analysis
    • Kołtowska-Häggström M, Kind P, Monson JP, Jonsson B. Growth hormone (GH) replacement in hypopituitary adults with GH deficiency evaluated by a utility-weighted quality of life index: a precursor to cost-utility analysis. Clin Endocrinol (Oxf). 2008;68(1):122-9.
    • (2008) Clin Endocrinol (Oxf) , vol.68 , Issue.1 , pp. 122-129
    • Kołtowska-Häggström, M.1    Kind, P.2    Monson, J.P.3    Jonsson, B.4
  • 36
    • 0142095008 scopus 로고    scopus 로고
    • Do all adults with growth hormone deficiency require growth hormone treatment?
    • Brooke AM, Monson JP. Do all adults with growth hormone deficiency require growth hormone treatment? Ann Med. 2003;35(6):419-24.
    • (2003) Ann Med , vol.35 , Issue.6 , pp. 419-424
    • Brooke, A.M.1    Monson, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.