Malignant epithelioid angiomyolipoma of the kidney in a patient with tuberous sclerosis: An autopsy case report with p53 gene mutation analysis

Pathology Research and Practice

Volumn 204, Issue 10, 2008, Pages 771-777

  Sato, Katsuaki ^a   Ueda, Yoshimichi ^a   Tachibana, Hiromichi ^a   Miyazawa, Katsuhito ^a   Chikazawa, Ippei ^a   Kaji, Sachiko ^a   Nojima, Takayuki ^a   Katsuda, Shogo ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Epithelioid angiomyolipoma; Kidney; Metastasis; p53 gene; Tuberous sclerosis

Indexed keywords

MELAN A; MONOCLONAL ANTIBODY HMB 45; PROTEIN P53;

ADULT; ANGIOMYOLIPOMA; ARTICLE; AUTOPSY; CASE REPORT; CELL NUCLEUS; CELL PROLIFERATION; CELL SIZE; COMPUTER ASSISTED TOMOGRAPHY; CYTOPLASM; DEATH; EOSINOPHIL; GENE MUTATION; GENETIC ANALYSIS; HEART ARREST; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFERIOR CAVA VEIN; KIDNEY MASS; KIDNEY TUMOR; LIVER METASTASIS; LUNG METASTASIS; MALE; MALIGNANT TRANSFORMATION; MESENTERY TUMOR; MICROSCOPY; MITOSIS; NEPHRECTOMY; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUBEROUS SCLEROSIS; TUMOR CELL; VASCULAR NECROSIS;

ADULT; ANGIOMYOLIPOMA; AUTOPSY; CELL PROLIFERATION; DNA MUTATIONAL ANALYSIS; EPITHELIOID CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; NEOPLASM METASTASIS; NEPHRECTOMY; POLYMERASE CHAIN REACTION; RECURRENCE; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 52049125234     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2008.04.008     Document Type: Article

References (30)

1. Abdulla M., Bui H.X., del Rosario A.D., Wolf B.C., and Ross J.S. Renal angiomyolipoma. DNA content and immunohistochemical study of classic and multicentric variants. Arch. Pathol. Lab. Med. 118 (1994) 735-739
2. Al-Saleem T., Wessner L.L., Scheithauer B.W., Patterson K., Roach E.S., Dreyer S.J., Fujikawa K., Bjornsson J., Bernstein J., and Henske E.P. Malignant tumors of the kidney brain, and soft tissues in children and young adults with the tuberous sclerosis complex. Cancer 83 (1998) 2208-2216
3. Amin M.B. Epithelioid angiomyolipoma. In: Eble J.N., Sauter G., Epstein J.I., and Sesterhenn I.A. (Eds). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs (2004), IARC Press, Lyon 68-69
4. Belanger E.C., Dhamanaskar P.K., and Mai K.T. Epithelioid angiomyolipoma of the kidney mimicking renal sarcoma. Histopathology 47 (2005) 433-435
5. Busch F.M., Bark C.J., and Clydine H.R. Benign renal angiomyolipoma with regional lymph node involvement. J. Urol. 116 (1976) 715-717
6. Chandrasoma S., Moatamed N., Chang A., Daneshmand S., and Ma Y. Angiomyolipoma of the kidney: expanding disease spectrum demonstrated by 3 cases. Appl. Immunohistochem. Mol. Morphol. 12 (2004) 277-283
7. Christiano A.P., Yang X., and Gerber G.S. Malignant transformation of renal angiomyolipoma. J. Urol. 161 (1999) 1900-1901
8. Cibas E.S., Goss G.A., Kulke M.H., Demetri G.D., and Fletcher C.D. Malignant epithelioid angiomyolipoma ('sarcoma ex angiomyolipoma') of the kidney: a case report and review of the literature. Am. J. Surg. Pathol. 25 (2001) 121-126
9. Csanaky G., Szereday Z., Magyarlaki T., Méhes G., Herbert T., and Buzogány I. Renal angiomyolipoma: report of three cases with regional lymph node involvement and/or with renal cell carcinoma. Tumori 81 (1995) 469-474
10. Ferry J.A., Malt R.A., and Young R.H. Renal angiomyolipoma with sarcomatous transformation and pulmonary metastases. Am. J. Surg. Pathol. 15 (1991) 1083-1088
11. Huang K.H., Huang C.Y., Chung S.D., Pu Y.S., Shun C.T., and Chen J. Malignant epithelioid angiomyolipoma of the kidney. J. Formos. Med. Assoc. 106 (2007) S51-S54
12. Hulbert J.C., and Graf R. Involvement of the spleen by renal angiomyolipoma: metastasis or multicentricity?. J. Urol. 130 (1983) 328-329
13. Kawaguchi K., Oda Y., Nakanishi K., Saito T., Tamiya S., Nakahara K., Matsuoka H., and Tsuneyoshi M. Malignant transformation of renal angiomyolipoma: a case report. Am. J. Surg. Pathol. 26 (2002) 523-529
14. Lane D.P. Cancer. p53, guardian of the genome. Nature 358 (1992) 15-16
15. L'Hostis H., Deminiere C., Ferriere J.M., and Coindre J.M. Renal angiomyolipoma: a clinicopathologic immunohistochemical, and follow-up study of 46 cases. Am. J. Surg. Pathol. 23 (1999) 1011-1020
16. Lin W.C., Wang J.H., Wei C.J., Pan C.C., and Chang C.Y. Malignant renal epithelioid angiomyolipoma with aggressive behavior and distant metastasis. J. Chin. Med. Assoc. 66 (2003) 303-306
17. Ma L., Kowalski D., Javed K., and Hui P. Atypical angiomyolipoma of kidney in a patient with tuberous sclerosis: a case report with p53 gene mutation analysis. Arch. Pathol. Lab. Med. 129 (2005) 676-679
18. Mai K.T., Yazdi H.M., Perkins D.G., and Thijssen A. Fine needle aspiration biopsy of epithelioid angiomyolipoma. A case report. Acta Cytol. 45 (2001) 233-236
19. Martignoni G., Pea M., Rigaud G., Manfrin E., Colato C., Zamboni G., Scarpa A., Tardanico R., Roncalli M., and Bonetti F. Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions. Am. J. Surg. Pathol. 24 (2000) 889-894
20. Mojica W.D., Jovanoska S., and Bernacki E.G. Epithelioid angiomyolipoma: appearance on fine-needle aspiration report of a case. Diagn. Cytopathol. 23 (2000) 192-195
21. Ong A., Pinto P., Kim F., and Kavoussi L. Recurrent renal epithelioid angiomyolipoma. Urology 61 (2003) 1035iii-1035v
22. Park H.K., Zhang S., Wong M.K., and Kim H.L. Clinical presentation of epithelioid angiomyolipoma. Int. J. Urol. 14 (2007) 21-25
23. Pea M., Bonetti F., Martignoni G., Henske E.P., Manfrin E., Colato C., and Bernstein J. Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma. Am. J. Surg. Pathol. 22 (1998) 180-187
24. Radin R., and Ma Y. Malignant epithelioid renal angiomyolipoma in a patient with tuberous sclerosis. J. Comput. Assist. Tomogr. 25 (2001) 873-875
25. Sato K., Ueda Y., Shikata H., and Katsuda S. Bronchioloalveolar carcinoma of mixed mucinous and nonmucinous type: immunohistochemical studies and mutation analysis of the p53 gene. Pathol. Res. Pract. 202 (2006) 751-756
26. Soong R., Robbins P.D., Dix B.R., Grieu F., Lim B., Knowles S., Williams K.E., Turbett G.R., House A.K., and Iacopetta B.J. Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas. Hum. Pathol. 27 (1996) 1050-1055
27. Takahashi N., Kitahara R., Hishimoto Y., Ohguro A., Hashimoto Y., and Suzuki T. Malignant transformation of renal angiomyolipoma. Int. J. Urol. 10 (2003) 271-273
28. Umeyama T., Saitoh Y., Tomaru Y., and Kitaura K. Bilateral renal angiomyolipoma associated with bilateral renal vein and inferior vena caval thrombi. J. Urol. 148 (1992) 1885-1887
29. Yamamoto T., Ito K., Suzuki K., Yamanaka H., Ebihara K., and Sasaki A. Rapidly progressive malignant epithelioid angiomyolipoma of the kidney. J. Urol. 168 (2002) 190-191
30. Yip S.K., Sim C.S., and Tan B.S. Liver metastasis and local recurrence after radical nephrectomy for an atypical angiomyolipoma. J. Urol. 165 (2001) 898-899