Is p16INK4a protein expression in oral ST lesions a reliable precancerous marker?

International Journal of Oral and Maxillofacial Surgery

Volumn 37, Issue 9, 2008, Pages 840-846

  Greer Jr , R O ^a,b   Meyers, A ^b   Said, S M ^b   Shroyer, K R ^c  

^a University of Colorado at Denver and Health Sciences   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

human papillomavirus; p16; squamous cell carcinoma; ST keratosis

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P53; VIRUS DNA;

ALVEOLAR RIDGE; ALVEOLAR RIDGE KERATOSIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA DETERMINATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATOSIS; MAJOR CLINICAL STUDY; MOUTH LESION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SMOKELESS TOBACCO; SMOKELESS TOBACCO KERATOSIS; SQUAMOUS CELL CARCINOMA; VIRUS DETECTION; WART VIRUS;

CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, VIRAL; HUMANS; IMMUNOHISTOCHEMISTRY; KERATOSIS; LEUKOPLAKIA, ORAL; MOUTH NEOPLASMS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PRECANCEROUS CONDITIONS; SEVERITY OF ILLNESS INDEX; TOBACCO, SMOKELESS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 52049118517     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijom.2008.05.015     Document Type: Article

References (25)

1. Accortt N.A., Waterbor J.W., Beall C., and Howard G. Cancer incidence among a cohort of smokeless tobacco users. Cancer Causes and Control 16 (2005) 1107-1115
2. Ambrosch P., Schlott T., Hilmes D., and Ruschenburg I. p16 alterations and retinoblastoma protein expression in squamous cell carcinoma and neighboring dysplasia from upper aerodigestive tract. Vichows Arch 438 (2001) 343-349
3. Andersson S., Hansson B., Norman I., Gaberi V., Mints M., Hjerpe A., Karlsen F., and Johansson B. Expression of E6/E7 mRNA from 'high risk' human papillomavirus in relation to CIN grade, viral load and p16INK4a. Int J Oncol 29 (2006) 705-711
4. INK4a is a reliable marker of human papillomavirus-induced oral high grade squamous dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 (2006) 77-81
5. Dehn D., Torkko K.C., and Shroyer K. Human papillomavirus testing and molecular markers of cervical dysplasia and carcinoma. Cancer Cytopathol 111 (2007) 1-14
6. Doorbar J. The papillomavirus life cycle. J Clin Virol 32 (2005) S7-S15
7. Dyson N., Howley P.M., Munger K., and Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243 (1989) 934-937
8. Giovino G.A., Schooley M.W., Zhu B.P., Chrismon J.H., Tomar S.L., Peddicord J.P., Merritt R.K., Husten C.G., and Eriksen M.P. Surveillance for selected tobacco use behaviors - United States, 1900-1994. MMWR Morph Morb Wkly Rep CDC Surveill Summ 54 (1994) 1-43
9. INK4a, a new marker that correlates with dysplasia in oral squamoproliferative lesions. Am J Pathol 29 (2005) 792-796
10. Greer R.O., and Poulson T.C. Oral changes associated with the use of smokeless tobacco by teenagers. Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endod 56 (1983) 275-284
11. Greer R.O., Eversole L.R., and Crosby L.K. Detection of papillomavirus genomic DNA in oral epithelial dysplasias, oral smokeless tobacco associated leukoplakias and epithelial malignancy. J Oral Maxillofac Surg 48 (1990) 1201-1205
12. Greer R.O., Hoernig G., and Shroyer K.R. Telomerase expression in precancerous oral verrucous leukoplakia. Int J Oral Biol 24 (1999) 1-5
13. Jarboe E.A., Thompson L.C., Heinz D., McGregor J.A., and Shroyer K.R. Telomerase and HPV as Diagnostic Adjuncts for Cervical Dysplasia and Carcinoma. Human Pathology 35 (2004) 396-402
14. INK4a and 14 ARF in patients with severe oral epithelial dysplasia. Cancer Research 62 (2002) 5295-5300
15. Kulkarni V., and Saranath D. Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues. Oral Oncology 40 (2004) 145-153
16. Leopardi E.A., Poulson T.C., Nieger B.L., Lindenmuth J.E., and Greer R.O. Smokeless tobacco usage patterns and male athlete sequellae: A Report of two surveys and associated intervention strategies among Utah adolescents. J Cancer Ed 4 (1989) 125-134
17. Martin C.M., Astbury K., and O'Leary J.J. Molecular profiling of cervical neoplasia. Expert Rev Mol Diagn 6 (2006) 217-229
18. Natarajan E, Woo RS. Alveolar ridge keratosis: A clinicopathologic entity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004: 98(Abstract) 2000.
19. Scheurer M.E., Tortolero-Luna G., and Adler-Storthz K. Human papillomavirus infection: biology, epidemiology, and prevention. Int J Gynecol Cancer 15 (2005) 727-746
20. Shroyer K.R., and Greer R.O. Detection of human papillomavirus DNA by in situ DNA hybridization and polymerase chain reaction in premalignant and malignant oral lesions. Oral Surg Oral Med Oral Pathol 71 (1991) 708-713
21. Ueda Y., Enomoto T., Miyatake T., Ozaki K., Yoshizaki T., Kanao H., Ueno Y., Nakashima R., Shroyer K.R., and Murata Y. Monoclonal expansion triggered by integration of high-risk type HPVs is an initial step for cervical carcinogenesis. Laboratory Investigation 83 (2003) 1517-1727
22. Wolf J.K., and Ramirez P.T. The molecular biology of cervical cancer. Cancer Invest 19 (2001) 621-629
23. Zhang H.S., Postigo A.A., and Dean D.C. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a., TGFbeta, and contact inhibition. Cell 97 (1999) 53-61
24. zur Hausen H. Papillomavirus infections - a major cause of human cancers. Biochim Biophys Acta 1288 (1996) F55-F78
25. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. National Rev Cancer 2 (2002) 342-350