Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique I. Formulation and process variables affecting pellet characteristics

International Journal of Pharmaceutics

Volumn 359, Issue 1-2, 2008, Pages 158-166

  Cheboyina, Sreekhar ^a,b   Wyandt, Christy M ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b MEDTRONIC INC   (United States)

Author keywords

Freeze pelletization; Matrix pellets; Surface chemistry; Sustained release; Viscosity; Waxes

Indexed keywords

DILTIAZEM; GLYCEROL; SILICA GEL; SILICON DIOXIDE; SURFACTANT; THEOPHYLLINE; WAX;

ARTICLE; CHEMISTRY; COLLOID; CRYSTALLIZATION; DELAYED RELEASE FORMULATION; DRUG STABILITY; FREEZING; PARTICLE SIZE; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; COLLOIDS; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DILTIAZEM; DRUG STABILITY; FREEZING; GLYCEROL; PARTICLE SIZE; SILICON DIOXIDE; SOLUBILITY; SURFACE-ACTIVE AGENTS; THEOPHYLLINE; WAXES;

EID: 52049116688     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.04.011     Document Type: Article

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