Sarcopenia and aging: Etiological aspects and therapeutic options;Sarcopenia Associada ao envelhecimento: Aspectos etiológicos e opções terapêuticas

Revista Brasileira de Reumatologia

Volumn 46, Issue 6, 2006, Pages 391-397

  de Araujo Silva, Tatiana Alves ^a   Frisoli Junior, Alberto ^a   Medeiros Pinheiro, Marcelo ^a   Szejnfeld, Vera Lúcia ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Body composition; Elderly; Functional dependence; Sarcopenia

Indexed keywords

CYTOKINE; GROWTH HORMONE; INTERLEUKIN 1; INTERLEUKIN 6; NANDROLONE DECANOATE; PLACEBO; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

AGING; ARTICLE; CALORIC RESTRICTION; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DENSITOMETRY; DISABILITY; ECHOGRAPHY; ECONOMIC ASPECT; ELDERLY CARE; EXERCISE; FRAIL ELDERLY; HORMONE DEFICIENCY; HUMAN; IMPEDANCE; MEDICAL DECISION MAKING; MUSCLE ATROPHY; MUSCLE INNERVATION; MUSCLE MASS; MUSCLE STRENGTH; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PREVALENCE; PROTEIN RESTRICTION; SKELETAL MUSCLE; SOCIAL ASPECT;

EID: 52049101389     PISSN: 04825004     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Freitas EV, Py L, Néri AL, Cançado FAX, Gorzoni ML, Rocha SM: Tratado de Geriatria e Gerontologia, Guanabara-Koogan, 2002.
2. Rice DP, La Plante MP: Medical expenditures for disability and disabling comorbidity. Am J Public Health 82: 739-41, 1992.
3. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB: Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332: 556-61, 1995.
4. Fried LP, Guralnik JM: Disability in older adults: evidence regarding significance, etiology, and risk. J Am Geriatr Soc 45: 92-100, 1997.
5. Roubenoff R, Hughes VA: Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci 55: M716-24, 2000.
6. Forbes GB, Reina JC: Adult lean body mass declines with age: some longitudinal observations. Metabol 19: 653-63; 1970.
7. Frontera WR, Hughes VA, Lutz KJ, Evans WJ: A cross sectional study of muscle strength and mass in 45- to 78-yr-old men and women. J Appl Phys 71: 644-50, 1991.
8. Baumgartner RN, Koehler KM, Gallagher D, et al: Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147: 755-63, 1998.
9. Rosenberg IH: Summary comments. Am J Clin Nutr 50: 1231-3, 1989.
10. Rosenberg IH: Sarcopenia: origins and clinical relevance. J Nutr 127: 990S-1S, 1997.
11. Tzankoff SP, Norris AH: Effect of muscle mass decrease on age-related BMR changes. J Appl Phys 43: 1001-6, 1977.
12. Fleg JL, Lakatta EG: Role of muscle loss in the age associated reduction in VO2 max. J Appl Phys 65: 1147-51, 1988.
13. Janssen I, Heymsfield SB, Wang ZM, Ross R: Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol 89: 81-8, 2000.
14. Doherty TJ, Brown WF: The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults. Muscle Nerve 16: 355-66, 1993.
15. Gallagher D, Visser M, De Meersman RE, et al: Appendicular skeletal muscle mass: effects of age, gender, and ethnicity. J Appl Physiol 83: 229-39, 1997.
16. Mitsiopoulos N, Baumgartner RN, Heymsfield SB, Lyons W, Gallagher D, Ross R: Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol 85: 115-22, 1998.
17. Melton LJ 3rd, Khosla S, Crowson CS, O'Connor MK, O'Fallon WM, Riggs BL: Epidemiology of sarcopenia. J Am Ger Soc 48: 625-30; 2000.
18. Iannuzzi-Sucich M, Prestwood KM, Kenny AM: Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol 57: M772-7, 2002.
19. Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R: Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women. Am J Epidemiol 159: 413-21, 2004.
20. Doherty TJ: Invited Review: Aging and Sarcopenia. J Appl Physiol 95: 1717-27, 2003.
21. Larsson L, Sjodin B, Karlsson J: Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22-65 years. Acta Physiol Scand 103: 31-9, 1978.
22. Lexell J, Downham DY: What determines the muscle cross-sectional area? J Neurol Sci 111:113-4, 1992.
23. Doherty TJ, Brown WF: Motor unit number estimation: methods and applications. In: Neuromuscular Function and Disease: Basic, Clinical, and Electrodiagnostic Aspects, edited by Brown WF, Bolton CF, and Aminoff MJ. Philadelphia, PA: Saunders. p. 274-290, 2002.
24. Kamel HK, Maas D, Duthie EH Jr: Role of hormones in the pathogenesis and management of sarcopenia. Drugs Aging 19: 865-77, 2002.
25. Bhasin S: Testosterone supplementation for aging-associated sarcopenia. J Gerontol 58: 1002-8, 2003.
26. Perry HM III, Miller DK, Patrick P, Morley JE: Testosterone and leptin in older African-American men: relationship to age, strength, function, and season. Metabolism 49: 1085-91, 2000.
27. Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS: Sarcopenia. J Lab Clin Med 137: 231-43, 2001.
28. Calloway DH, Zanni E: Energy requirements and energy expenditure of elderly men. Am J Clin Nutr 33: 2088-92, 1980.
29. Vaughan L, Zurlo F, Ravussin E: Aging and energy expenditure. Am J Clin Nutr 53: 821-5, 1991.
30. Greenlund LJ, Nair KS: Sarcopenia-consequences, mechanisms, and potential therapies. Mech Ageing Dev 124: 287-99, 2003.
31. Roberts SB: Effects of aging on energy requirements and the control of food intake in men. J Gerontol A Biol Sci Med Sci 50: 101-6, 1995.
32. Morley JE, Kumar VB, Mattammal MB, Farr S, Morley PM, Flood JF: Inhibition of feeding by a nitric oxide synthase inhibitor: effects of aging. Eur J Pharmacol 311: 15-9, 1996.
33. Morley JE, Thomas DR: Anorexia and aging: pathophysiology. Nutrition 15: 499-503, 1999.
34. Morley JE: Anorexia, body composition, and ageing. Curr Opin Clin Nutr and Metabol Care 4: 9-13, 2001.
35. Morley JE: Anorexia of aging: physiologic and pathologic. Am J Clin Nutr 66: 760-73, 1997.
36. Bales CW, Ritchie CS: Sarcopenia, weight loss and nutritional frailty in the elderly. Annu Rev Nutr 22: 309-23, 2002.
37. Campbell W, Crim MC, Dallal GE, Young VR, Evans WJ: Increased protein requirements in the elderly: new data and retrospective reassessments. Am J Clin Nutr 60: 167-75; 1994.
38. Roubenoff R, Harris TB, Abad LW, Wilson PW, Dallal GE, Dinarello CA: Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci 53: M20-6, 1998.
39. Evans WJ: Exercise, nutrition, and aging. Clin Geriatr Med 11: 725-34, 1995.
40. Evans WJ: Effects of exercise on senescent muscle. Clin Orthop S211-20, 2002.
41. Baumgartner RN: Body composition in healthy aging. Ann N Y Acad Sci 904: 437-48, 2000.
42. Gruenewald DA, Matsumoto AM: Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc 51: 101-15, 2003.
43. Borst SE: Interventions for sarcopenia and muscle weakness in older people. Age Ageing 33: 548-55, 2004.
44. Frisoli Júnior A, Chaves PH, Pinheiro MM, Szejnfeld VL: The effect of nandrolone decanoate on bone mineral density, muscle mass and hemoglobin levels in elderly women with osteoporosis: a double-blind, placebo controlled study. J Gerontol 60: 648-53, 2005.
45. Bross R, Javanbakht M, Bhasin SA: Anabolic interventions for aging-associated sarcopenia. J Clin Endoc Metab 84: 3420-30, 1999.
46. Bollerslev J, Moller J, Thomas S, Djoseland O, Christiansen JS: Dose dependent effects of recombinant human growth hormone on biochemical markers of bone and collagen metabolism in adult with growth hormone deficiency. Eur J Endocrinol 135: 666-71, 1996.
47. Christ ER, Chowienczyk PJ, Sonksen PH, Russel-Jones DL: Dynamies of lipoprotein metabolism in adult growth hormone deficiency. J Endocrinol Invest 22 (5 supl): 16-21, 1999.
48. Cohn L, Feller AG, Draper MW, Rudman IW, Rudman D: Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations. Clin Endocrinol 39: 417-25, 1993.
49. Yarasheski KE, Zachwieja JJ: Growth hormone therapy for the elderly: the fountain of youth proves toxic. JAMA 270: 1694, 1993.
50. Ades PA, Ballor DL, Ashikaga T, Utton JL, Nair KS: Weight training improves walking endurance in healthy elderly persons. Ann Int Med 124: 568-72, 1996.
51. Fiatarone MA, O'Neill EF, Ryan ND: Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330: 1769-75, 1994.
52. Larsson L, Teach PA: Muscle hypertrophy in bodybuilders. Eur J Appl Phys Occup Physiol 49: 301-6, 1982.
53. Hasten DL, Pak-Loduca J, Obert KA, Yarasheski KE: Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds. Am J Physiol Endocrinol Metab 278: E620-6, 2000.
54. Balagopal P, Schimke JC, Ades P, Adey D, Nair KS: Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise. Am J Physiol Endocrinol Metab 280: E203-8, 2001.
55. Sale DG: Neural adaptation to resistance training. Med Sci Sports Exerc 20 (Suppl): S135-45, 1988.
56. Hakkinen K, Pakarinen A, Newton RU, Kraemer WJ: Acute hormone responses to heavy resistance lower and upper extremity exercise in young versus old men. Eur J Appl Physiol Occup Physiol 77: 312-9, 1998.
57. Hakkinen K, Alen M, Pakarinen A, Newton RU, Kraemer WJ: Neuromuscular adaptation during prolonged strength training, detraining and re-strength-training in middle-aged and elderly people. Eur J Appl Physiol 83: 51-62, 2000.
58. Rawson ES, Wehnert ML, Clarkson PM: Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol 80: 139-44, 1999.
59. Campbell WW, Joseph LJO, Davey SL, Cyr-Campbell D, Anders RA, Evans WJ: Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men. J Appl Physiol 86: 29-39, 1999.