An abnormal pKa value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis

Biochemical and Biophysical Research Communications

Volumn 376, Issue 1, 2008, Pages 32-35

  Ishikawa, Takuya ^a   Chatake, Toshiyuki ^a   Morimoto, Yukio ^a   Maeda, Mitsuru ^b   Kurihara, Kazuo ^b   Tanaka, Ichiro ^c   Niimura, Nobuo ^c  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN ATOMIC ENERGY AGENCY   (Japan)

^c IBARAKI UNIVERSITY   (Japan)

Author keywords

Histidine; Insulin; Neutron crystallography; Polymerization; Protonation

Indexed keywords

HISTIDINE; PIG INSULIN; ZINC ION;

ARTICLE; CRYSTALLOGRAPHY; HORMONE DETERMINATION; HORMONE STRUCTURE; NONHUMAN; PANCREAS ISLET BETA CELL; PKA; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANIMALS; HISTIDINE; INSULIN; NEUTRON DIFFRACTION; SWINE; ZINC;

EID: 52049087315     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.08.071     Document Type: Article

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