Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart

European Journal of Pharmacology

Volumn 595, Issue 1-3, 2008, Pages 58-64

  Heinen, André ^a   Huhn, Ragnar ^a   Hollmann, Markus W ^a   Preckel, Benedikt ^a   Zuurbier, Coert J ^a   Schlack, Wolfgang ^a   Fräßdorf, Jan ^a   Weber, Nina C ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Glutamine; Isolated heart; Morphine; Preconditioning

Indexed keywords

GLUCOSE; GLUTAMINE; LACTIC ACID; MORPHINE; PYRUVIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; HEART INFARCTION SIZE; HEART PROTECTION; ISCHEMIC PRECONDITIONING; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOTONIC AGENTS; DRUG ADMINISTRATION SCHEDULE; GLUTAMINE; MALE; MORPHINE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; PERFUSION; RATS; RATS, WISTAR; REPERFUSION INJURY; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 52049083407     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.060     Document Type: Article

References (26)

1. Bolli R., Becker L., Gross G., Mentzer Jr. R., Balshaw D., and Lathrop D.A. Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ. Res. 95 (2004) 125-134
2. Chatham J.C., Gao Z.P., Bonen A., and Forder J.R. Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes. Cardiovasc. Res. 43 (1999) 96-106
3. Chatham J.C., Des R.C., and Forder J.R. Evidence of separate pathways for lactate uptake and release by the perfused rat heart. Am. J. Physiol: Endocrinol. Metab. 281 (2001) E794-E802
4. ATP channels. Circ. Res. 89 (2001) 273-278
5. Dirksen M.T., Laarman G.J., Simoons M.L., and Duncker D.J. Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies. Cardiovasc. Res. 74 (2007) 343-355
6. Hausenloy D.J., Maddock H.L., Baxter G.F., and Yellon D.M. Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?. Cardiovasc. Res. 55 (2002) 534-543
7. Jones S.P., Zachara N.E., Ngoh G.A., Hill B.G., Teshima Y., Bhatnagar A., Hart G.W., and Marban E. Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation 117 (2008) 1172-1182
8. Khogali S.E., Harper A.A., Lyall J.A., and Rennie M.J. Effects of L-glutamine on post-ischaemic cardiac function: protection and rescue. J. Mol. Cell. Cardiol. 30 (1998) 819-827
9. Khogali S.E., Pringle S.D., Weryk B.V., and Rennie M.J. Is glutamine beneficial in ischemic heart disease?. Nutrition 18 (2002) 123-126
10. ATP channels. Circ. Res. 84 (1999) 1396-1400
11. Liu J., Marchase R.B., and Chatham J.C. Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. J. Mol. Cell. Cardiol. 42 (2007) 177-185
12. ATP channels and opioid receptors. Anesthesiology 98 (2003) 705-711
13. Majewski N., Nogueira V., Bhaskar P., Coy P.E., Skeen J.E., Gottlob K., Chandel N.S., Thompson C.B., Robey R.B., and Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 16 (2004) 819-830
14. McPherson B.C., and Yao Z. Signal transduction of opioid-induced cardioprotection in ischemia-reperfusion. Anesthesiology 94 (2001) 1082-1088
15. Murphy E., and Steenbergen C. Preconditioning: the mitochondrial connection. Annu. Rev. Physiol. 69 (2007) 51-67
16. Peart J.N., and Gross G.J. Exogenous activation of delta- and kappa-opioid receptors affords cardioprotection in isolated murine heart. Basic Res. Cardiol. 99 (2004) 29-37
17. Peart J.N., Gross E.R., and Gross G.J. Opioid-induced preconditioning: recent advances and future perspectives. Vasc. Pharmacol. 42 (2005) 211-218
18. Schultz J.E., Rose E., Yao Z., and Gross G.J. Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts. Am. J. Physiol. 268 (1995) H2157-H2161
19. Schultz J.E., Hsu A.K., and Gross G.J. Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circ. Res. 78 (1996) 1100-1104
20. Schultz J.E., Hsu A.K., and Gross G.J. Ischemic preconditioning in the intact rat heart is mediated by delta1- but not mu- or kappa-opioid receptors. Circulation 97 (1998) 1282-1289
21. Schultz J.J., Hsu A.K., and Gross G.J. Ischemic preconditioning and morphine-induced cardioprotection involve the delta (delta)-opioid receptor in the intact rat heart. J. Mol. Cell. Cardiol. 29 (1997) 2187-2195
22. Stein W.H., and Moore S. The free amino acids of human blood plasma. J. Biol. Chem. 211 (1954) 915-926
23. Yellon D.M., and Hausenloy D.J. Myocardial reperfusion injury. N. Engl. J. Med. 357 (2007) 1121-1135
24. Zhang Y., Irwin M.G., and Wong T.M. Remifentanil preconditioning protects against ischemic injury in the intact rat heart. Anesthesiology 101 (2004) 918-923
25. Zhang Y., Irwin M.G., Wong T.M., Chen M., and Cao C.M. Remifentanil preconditioning confers cardioprotection via cardiac kappa- and delta-opioid receptors. Anesthesiology 102 (2005) 371-378
26. Zuurbier C.J., Eerbeek O., and Meijer A.J. Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution. Am. J. Physiol, Heart Circ. Physiol. 289 (2005) H496-H499