Galactose residues on the lipooligosaccharide of Moraxella catarrhalis 26404 form the epitope recognized by the bactericidal antiserum from conjugate vaccination

Infection and Immunity

Volumn 76, Issue 9, 2008, Pages 4251-4258

  Yu, Shengqing ^a   Xie, Hang ^a   Datta, Anup ^b   Naidu, Natasha ^b   Gu, Xin Xing ^a,c  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b University of California San Diego   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTISERUM; EPITOPE; GALACTOSE; GALACTOSYLTRANSFERASE; KANAMYCIN; LIPOOLIGOSACCHARIDE; MONOSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE; GENE INSERTION; LGT2 GENE; MORAXELLA CATARRHALIS; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEROTYPE; STRUCTURE ANALYSIS; VACCINATION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; BLOTTING, WESTERN; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; FLOW CYTOMETRY; GALACTOSE; LIPOPOLYSACCHARIDES; MICE; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; MORAXELLA (BRANHAMELLA) CATARRHALIS; MUTAGENESIS, INSERTIONAL; SEQUENCE ANALYSIS, DNA;

EID: 51949112533     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01570-07     Document Type: Article

References (43)

1. Burman, L. A., M. Leinonen, and B. Trollfors. 1994. Use of serology to diagnose pneumonia caused by nonencapsulated Haemophilus influenzae and Moraxella catarrhalis. J. Infect. Dis. 170:220-222.
2. Ciucanu, I., and F. Kerek. 1984. A simple and rapid method for the per-methylation of carbohydrates. Carbohydr. Res. 131:209-217.
3. Cripps, A. W., and D. C. Otczyk. 2006. Prospects for a vaccine against otitis media. Expert Rev. Vaccines 5:517-534.
4. Daoud, A., F. Abuekteish. and H. Masaadeh. 1996. Neonatal meningitis due to Moraxella catarrhalis and review of the literature. Ann. Trop. Paediatr. 16:199-201.
5. Doyle, W. J. 1989. Animal models of otitis media: other pathogens. Pediatr. Infect. Dis. J. 81(Suppl.):S45-S47.
6. Edebrink, P., P. E. Jansson, M. M. Rahman, G. Widmalm, T. Holme, M. Rahman, and A. Weintraub. 1994. Structural studies of the O-polysaccharide from the lipopolysaccharide of Moraxella (Branhamella) catarrhalis serotype A (strain ATCC 25238). Carbohydr. Res. 257:269-284.
7. Edebrink, P., P. E. Jansson, M. M. Rahman, G. Widmalm, T. Holme, and M. Rahman. 1995. Structural studies of the O-antigen oligosaccharides from two strains of Moraxella catarrhalis serotype C. Carbohydr Res. 266:237-261.
8. Edebrink, P., P. E. Jansson, G. Widmalm, T. Holme, and M. Rahman. 1996. The structures of oligosaccharides isolated from the lipopolysaccharide of Moraxella catarrhalis serotype B, strain CCUG 3292. Carbohydr. Res. 295: 127-146.
9. Edwards, K. J., S. Allen, B. W. Gibson, and A. A. Campagnari. 2005. Characterization of a cluster of three glycosyltransferase enzymes essential for Moraxella catarrhalis lipooligosaccharide assembly. J. Bacteriol. 187:2939-2947.
10. Felmingham, D., and J. Washington. 1999. Trends in the antimicrobial susceptibility of bacterial respiratory tract pathogens-findings of the Alexander Project 1992-1996. J. Chemother. 11(Suppl. 1):5-21.
11. Fomsgaard, J. S., A. Fomsgaard, N. Hoiby, B. Bruun, and C. Galanos. 1991. Comparative immunochemistry of lipopolysaccharides from Branhamella catarrhalis strains. Infect. Immun. 59:3346-3349.
12. Forsgren, A., M. Brant, M. Karamehmedovic, and K. Riesbeck. 2003. The immunoglobulin D-binding protein MID from Moraxella catarrhalis is also an adhesin. Infect. Immun. 71:3302-3309.
13. Gergova, R. T., I. D. Iankov, I. H. Haralambieva, and I. G. Mitov. 2007. Bactericidal monoclonal antibody against Moraxella catarrhalis lipooligosaccharide cross-reacts with Haemophilus spp. Curr. Microbiol. 54:85-90.
14. Gu, X.-X., J. Chen, S. J. Barenkamp, J. B. Robbins, C.-M. Tsai, D. J. Lim, and J. Battery. 1998. Synthesis and characterization of lipooligosaccharide-based conjugates as vaccine candidates for Moraxella (Branhamella) catarrhalis. Infect. Immun. 66:1891-1897.
15. Helander, I. M., K. Nummila, I. Kilpelainen, and M. Vaara. 1995. Increased substitution of phosphate groups in lipopolysaccharides and lipid A of poly myxin-resistant mutants of Salmonella typhimurium and Escherichia coli. Prog. Clin. Biol. Res. 392:15-23.
16. Holm, M. M., S. L. Vanlerberg, D. D. Sledjeski, and E. R. Lafontaine. 2003. The Hag protein of Moraxella catarrhalis strain O35E is associated with adherence to human lung and middle ear cells. Infect. Immun. 71:4977-4984.
17. Holme, T., M. Rahman, P. E. Jansson, and G. Widmalm. 1999. The lipopolysaccharide of Moraxella catarrhalis structural relationships and antigenic properties. Eur. J. Biochem. 265:524-529.
18. Hu, W. G., J. Chen, F. M. Collins, and X. X. Gu. 1999. An aerosol challenge mouse model for Moraxella catarrhalis. Vaccine 18:799-804.
19. Hu, W. G., J. Chen, J. F. Battey, and X. X. Gu. 2000. Enhancement of clearance of bacteria from murine lungs by immunization with detoxified lipooligosaccharide from Moraxella catarrhalis conjugated to proteins. Infect. Immun. 68:4980-4985.
20. Hu, W. G., J. Chen, J. C. McMichael, and X. X. Gu. 2001. Functional characteristics of a protective monoclonal antibody against serotype A and C lipooligo-saccharides from Moraxella catarrhalis. Infect. Immun. 69:1358-1363.
21. Jiao, X., T. Hirano, Y. Hou, and X. X. Gu. 2002. Specific immune responses and enhancement of murine pulmonary clearance of Moraxella catarrhalis by intranasal immunization with a detoxified lipooligosaccharide conjugate vaccine. Infect. Immun. 70:5982-5989.
22. Laferriere, C. A., R. K. Sood, J. M. de Muys, F. Miction, and H. J. Jennings. 1998. Streptococcus pneumoniae type 14 polysaccharide- conjugate vaccines: length stabilization of opsonophagocytic conformational polysaccharide epitopes. Infect. Immun. 66:2441-2446.
23. McMichael, J. C. 2000. Vaccines for Moraxella catarrhalis. Vaccine 19:S101-S107.
24. Murphy, T. F. 2005. Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis: progress and challenges. Expert Rev. Vaccines 4:843-853.
25. Murphy, T. F., A. L. Brauer, B. J. Grant, and S. Sethi. 2005. Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. Am. J. Respir. Crit. Care Med. 172:195-199.
26. Oishi, K., H. Tanaka, F. Sonoda, S. Borann, K. Ahmed, Y. Utsunomiya, K. Watanabe, T. Nagatake, M. Vaneechoutte, G. Verschraegen, and K. Matsumoto. 1996. A monoclonal antibody reactive with a common epitope of Moraxella (Branhamella) catarrhalis lipopolysaccharides. Clin. Diagn. Lab. Immunol. 3:351-354.
27. Peak, I. R., M. P. Jennings, D. W. Hood, M. Bisercic, and E. R. Moxon. 1996. Tetrameric repeat units associated with virulence factor phase variation in Haemophilus also occur in Neisseria spp. and Moraxella catarrhalis. FEMS Microbiol. Lett. 137:109-114.
28. Peng, D., B. P. Choudhury, R. S. Petralia, R. W. Carlson, and X.-X. Gu. 2005. Roles of 3-deoxy-D-manno-2-octulosonic acid transferase from Moraxella catarrhalis in lipooligosaccharide biosynthesis and virulence. Infect. Immun. 73:4222-4230.
29. Peng, D., W. G. Hu, B. P. Choudhury, A. Muszynski, R. W. Carlson, and X.-X. Gu. 2007. Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane. FEBS J. 274:5350-5359.
30. Rahman, M., and T. Holme. 1996. Antibody response in rabbits to serotype-specific determinants in lipopolysaccharides from Moraxella catarrhalis. J. Med. Microbiol. 44:348-354.
31. Rahman, M., T. Holme, I. Jonsson, and A. Krook. 1995. Lack of serotype-specific antibody response to lipopolysaccharide antigens of Moraxella catarrhalis during lower respiratory tract infection. Eur. J. Clin. Microbiol. Infect. Dis. 14:297-304.
32. Rahman, M., A. B. Jonsson, and T. Holme. 1998. Monoclonal antibodies to the epitope alpha-Gal-(1-4)-beta-Gal-(1- of Moraxella catarrhalis LPS react with a similar epitope in type IV pili of Neisseria meningitidis. Microb. Pathog. 24:299-308.
33. Smith, P. K., R. I. Krobn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B. J. Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:76-35.
34. Tanaka, H., K. Oishi, F. Sonoda, A. Iwagaki, T. Nagatake, and K. Matsumoto. 1992. Biochemical analysis of lipopolysaccharides from respiratory pathogenic Branhamella catarrhalis strains and the role of anti-LPS antibodies in Branhamella respiratory infections. J. Jpn. Assoc. Infect. Dis. 66:709-715.
35. Tsai, C. M., and C. E. Frasch. 1982. A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. Anal. Biochem. 119:115-119.
36. Vaneechoutte, M., G. Verschraegen, G. Claeys, and A. M. Van Den Abeele. 1990. Serological typing of Branhamella catarrhalis strains on the basis of lipopolysaccharide antigens. J. Clin. Microbiol. 28:182-187.
37. Verduin, C. M., C. Hol, A. Fleer, H. van Dijk, and A. van Belkum. 2002. Moraxella catarrhalis: from emerging to established pathogen. Clin. Microbiol. Rev. 15:125-144.
38. Warburg, O., and W. Christian. 1942. Isolation and crystallization of eno-lase. Biochem. Z. 310:384-421.
39. York, W. S., A. G. Darvill. M. McNeil, T. T. Stevenson, and P. Albersheim. 1985. Isolation and characterization of plant cell walls and cell wall components. Methods Enzymol. 118:3-40.
40. Yu, S., and X.-X. Gu. 2005. Synthesis and characterization of lipooligosac-charide-based conjugate vaccines for serotype B Moraxella catarrhalis. Infect. Immun. 73:2790-2796.
41. Yu, S., and X.-X. Gu. 2007. Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis. Infect. Immun. 75:2974-2980.
42. Zaleski, A., N. K. Scheffler, P. Densen, F. K. Lee, A. A. Campagnari, B. W. Gibson, and M. A. Apicella. 2000. Lipooligosaccharide P(k) (Galα1-4Galβ1-4Glc) epitope of Moraxella catarrhalis is a factor in resistance to bactericidal activity mediated by normal human serum. Infect. Immun. 68:5261-5268.
43. Zou, W., R. Machenzie, L. Therien, T. Hirama, Q. Yang, M. A. Gidney, and H. J. Jennings. 1999. Conformational epitope of the type HI group B Streptococcus capsular polysaccharide. J. Immunol. 163:820-825.