Catalytic asymmetric addition of alcohols to imines: Enantioselective preparation of chiral N,O-aminals

Journal of the American Chemical Society

Volumn 130, Issue 37, 2008, Pages 12216-12217

  Li, Guilong ^a   Fronczek, Frank R ^b   Antilla, Jon C ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; IMINE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; ENANTIOSELECTIVITY; ISOMERIZATION; STEREOCHEMISTRY;

EID: 51949105698     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8033334     Document Type: Article

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35. Note that N-Boc substitution on the imine gave lower yields with good selectivity (61% yield, 84% ee) while the corresponding N-3,5-dimethoxy-bezoyl imine gave similar results (83% yield, 86% ee).
36. Please see Supporting Information for X-ray crystallographic details.