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3 or AgOTf to catalyze the reaction without the addition of Brønsted acids (see Refs. [6-8]).
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3 or AgOTf to catalyze the reaction without the addition of Brønsted acids (see Refs. [6-8]).
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This represents the first example of an enantioselective alkynylation with phenylacetylene and its derivatives. The use of alkyl-substituted alkynes have been reported in Ref, 51
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This represents the first example of an enantioselective alkynylation with phenylacetylene and its derivatives. The use of alkyl-substituted alkynes have been reported in Ref. [51].
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Experiments with chiral silver-binol complexes in combination with the achiral Brønsted acid diphenyl hydrogen phosphates resulted in racemic product
-
Experiments with chiral silver-binol complexes in combination with the achiral Brønsted acid diphenyl hydrogen phosphates resulted in racemic product.
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Experiments for the determination of the absolute configuration are given in the Supporting Information
-
Experiments for the determination of the absolute configuration are given in the Supporting Information.
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Note added in proof (July 31, 2007): After the acceptance of our manuscript a further article on metal catalysis with chiral counterions appeared: G. L. Hamilton, E. J. Kang, M. Mba, F. D. Toste, Science 2007, 317, 496.
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Note added in proof (July 31, 2007): After the acceptance of our manuscript a further article on metal catalysis with chiral counterions appeared: G. L. Hamilton, E. J. Kang, M. Mba, F. D. Toste, Science 2007, 317, 496.
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