The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

International Journal of Cancer

Volumn 123, Issue 8, 2008, Pages 1761-1769

  Sun, Yu ^a   Wong, Nicholas ^b   Guan, Yinghui ^b   Salamanca, Clara M ^a   Jung, Chien Cheng ^a   Lee, Jonathan M ^c   Gray, Joe W ^b,d   Auersperg, Nelly ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF OTTAWA   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

EEF1A2; Neoplastic progression; Oncogene; Ovarian cancer; Ovarian epithelial cells; ZNF217

Indexed keywords

EEF1A2; ELONGATION FACTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZNF217;

ANCHORAGE INDEPENDENT GROWTH; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL LINE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DENSITY; DRUG EFFECT; EPITHELIUM CELL; FEMALE; GENE NUMBER; HUMAN; HUMAN CELL; LENTIVIRINAE; OVARY CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; SINGLE NUCLEOTIDE POLYMORPHISM; STEM CELL;

APOPTOSIS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE DOSAGE; GENE EXPRESSION; HUMANS; OVARIAN NEOPLASMS; PEPTIDE ELONGATION FACTOR 1; PRECANCEROUS CONDITIONS; RNA, SMALL INTERFERING; TRANS-ACTIVATORS;

EID: 51949093672     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23708     Document Type: Article

References (26)

1. Tanner MM, Grenman S, Koul A, Johansson O, Meltzer P, Pejovic T, Borg A, Isola JJ. Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer. Clin Cancer Res 2000;6:1833-9.
2. Watanabe T, Katahira II, Hirasawa A, Ishiwata I, Emi M, Takayama M. Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers. Jpn J Cancer Res 2002;93:1114-22.
3. Kreig SR, Jin VX, Bieda MC, O'Geen H, Yaswen P, Green R, Farnham PJ. Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays. J Biol Chem 2007;282:9703-12.
4. Cowger JJM, Zhao Q, Isovic M, Torchia J. Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. Oncogene 2007;26:3378-86.
5. Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstain B, Mills GB, Stokoe D, Yaswen P, Colloins C. ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. Hum Mol Genet 2005;14:3219-25.
6. Quinlan KG, Verger A, Yaswen PK, Crossley M. Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. Biochem Biophys Acta 2007;1775:333-40.
7. Nonet GH, Stampfer MR, Chin K, Gray JW, Collins CC, Yaswen P. The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells. Cancer Res 2006;61:1250-4.
8. Li P, Maines-Bandiera S, Kuo WL, Guan Y, Sun Y, Hills M, Huang G, Collins CC, Leung PC, Gray JW, Auersperg N. Multiple roles of the candidate oncogene ZNF217 in ovarian epithelial neoplastic progression. Int J Cancer 2007;120:1863-73.
9. Amiri A, Noei F, Jeganathan S, Kulkarni G, Pinke DE, Lee JM. eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration. Oncogene 2007;26:3027-40.
10. Condeelis J. Elongation factor 1α, translation and the cytoskeleton. Trends Biochem Sci 1995;20:169-70.
11. Chung CM, Man C, Jin Y, Jin C, Guan XY, Wang Q, Wan TS, Cheung AL, Tsao SW. Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells. Mol Carcinog 2005;43:165-74.
12. Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature 2006;440:556-60.
13. Ejiri S. Moonlighting functions of polypeptide elongation factor 1: from actin bundling to zinc finger protein R1-associated nuclear localization. Biosci Biotechnol Biochem 2002;66:1-21.
14. Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM. Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet 2002;31:301-5.
15. Tomlinson VA, Newbery HJ, Bergmann JH, Boyd J, Scott D, Wray NR, Sellar GC, Gabra H, Graham A, Williams AR, Abbott CM. Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus. Brit J Can 2007;96:1613-20.
16. Tomlinson VA, Newbery HJ, Wray NR, Jackson J, Larionov A, Miller WR, Dixon JM, Abbott CM. Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. BMC Cancer 2005;5:113-19.
17. Li R, Wang H, Belkele BN, Yin Z, Caraway NP, Katz RL, Staass SA, Jiang F. Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene 2006;25:2628-35.
18. Kulkarni G, Turbin DA, Amiri A, Jeganathan S, Andrade-Navarro MA, Wu TD, Huntsman DG, Lee GM. Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer. Breast Cancer Res Treat 2007;102:31-41.
19. Zhu H, Lam DC, Han KC, Tin VP, Suen WS, Wang E, Lam WK, Cai WW, Chung LP, Wong MP. High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines. Cancer Lett 2007;245:303-14.
20. Ruest LB, Marcotte R, Wang E. Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. J Biol Chem 2007;277:5418-25.
21. Goncalves J, Malta-Vacas J, Louis M, Brault L, Bagrel D, Monteiro C, Brito M. Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells. Clin Chem Lab Med 2005;43:151-6.
22. Hu H, Li X. Transcriptional regulation in eukaryotic ribosomal protein genes. Genomics 2007;90:421-3.
23. Maines-Bandiera SL, Kruk PA, Auersperg N. Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix. Am J Obstet Gynecol 1992;167:729-35.
24. Chang R, Wang E. Mouse translation elongation factor eEF1A-2 interacts with Prdx-1 to protect cells against apoptotic death induced by oxidative stress. J Cell Biochem 2007;100:267-78.
25. Gangwani L, Mikrut M, Galcheva-Gargova Z, Davis RJ. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. J Cell Biol 1998;143:1471-84.
26. Cheung AL, Deng W. Telomere dysfunction, genome instability and cancer. Front Biosci 2008;13:2075-90.