Hemoglobin-based blood substitutes and risk of myocardial infarction and death - Reply

JAMA

Volumn 300, Issue 11, 2008, Pages 1298-1299

  Natanson, Charles ^a   Lurie, Peter ^b   Wolfe, Sidney M ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Public Citizen   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SUBSTITUTE; HEMOGLOBIN; NITRIC OXIDE;

BLOOD TRANSFUSION; CLINICAL RESEARCH; DEATH; HEART INFARCTION; LETTER; METHODOLOGY; MORTALITY; PRIORITY JOURNAL; RESEARCH ETHICS; RESEARCH SUBJECT; RISK BENEFIT ANALYSIS;

EID: 51949089336     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.300.11.1298     Document Type: Letter

References (7)

1. Levien LJ. South Africa: clinical experience with Hemopure [abstract]. ISBT Science Series. 2006;1(1):167-173. http://www.blackwell-synergy.com/ doi/abs/10.1111/j.1751-2824.2006.00025.x. Accessed July 1, 2008.
2. Olofsson C, Nyga° rds EB, Ponzer S, et al. A randomized, single-blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan) administered to orthopedic surgery patients with spinal anesthesia. Transfus Med. 2008;18(1):28-29.
3. Olofsson C, Ahl T, Johansson T, et al. A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified hemoglobin (Hemospan) in patients undergoing major orthopedic surgery. Anesthesiology. 2006;105(6):1153-1163.
4. Sloan EP, Koenigsberg M, Gens D, et al. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock. JAMA. 1999;282(19):1857-1864.
5. FDA presentation to BPAC: NMRC RESUS protocol using HBOC-21: December 14, 2006. US Food and Drug Administration Web site. http://www.fda.gov/ohrms/ dockets/ac/06/slides/2006-4270S_9.ppt. Accessed April 9, 2008.
6. Northfield Laboratories reports results of pivotal phase III trauma study [news release]. Northfield Laboratories Web site. http://phx.corporate-ir.net/ phoenix.zhtml?c=91374&p=irol-newsArticle&ID=1005951&highlight=. Accessed April 28, 2008.
7. Kerner T, Ahlers O, Veit S, et al. DCL-Hb for trauma patients with severe hemorrhagic shock: the European "On-Scene" multicenter study. Intensive Care Med. 2003;29(3):378-385.