The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine

Platelets

Volumn 19, Issue 5, 2008, Pages 352-358

  Nylander, M ^a,b,c   Lindahl, T L ^a   Bengtsson, T ^b   Grenegard M ^b  

^a Cardiovascular Inflammation Research Centre   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Epinephrine; Gingipain; PARs; Platelets; Porphyromonas gingivalis

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PERIODONTAL DISEASE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ADHESINS, BACTERIAL; APYRASE; ASPIRIN; BLOOD PLATELETS; CALCIUM SIGNALING; CYCLOOXYGENASE INHIBITORS; CYSTEINE ENDOPEPTIDASES; EPINEPHRINE; HUMANS; LEUPEPTINS; NEPHELOMETRY AND TURBIDIMETRY; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PORPHYROMONAS GINGIVALIS; PROTEASE INHIBITORS; PYRROLES; QUINAZOLINES; RECEPTORS, PROTEINASE-ACTIVATED; VIRULENCE; YOHIMBINE;

PORPHYROMONAS GINGIVALIS;

EID: 51849088127     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100802056102     Document Type: Article

References (28)

1. Cutler CW, Kalmar JR, Genco CA. Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis. Trends Microbiol 1995;3:45-51.
2. Lamont RJ, Jenkinson HF. Life below the gum line: Pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 1998;62:1244-1263.
3. Grenier D, Mayrand D. Functional characterization of extracellular vesicles produced by Bacteroides gingivalis. Infect Immun 1987;55:111-117.
4. Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B. Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor. Infect Immun 2002;70:6968-6975.
5. Grenier D, Imbeault S, Plamondon P, Grenier G, Nakayama K, Mayrand D. Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin. Infect Immun 2001;69:5166-5172.
6. Genco CA, Potempa J, Mikolajczyk-Pawlinska J, Travis J. Role of gingipains R in the pathogenesis of Porphyromonas gingivalis-mediated periodontal disease. Clin Infect Dis 1999;28:456-465.
7. Olczak T, Simpson W, Liu X, Genco CA. Iron and heme utilization in Porphyromonas gingivalis. FEMS Microbiol Rev 2005;29:119-144.
8. Beck JD, Offenbacher S, Williams R, Gibbs P, Garcia R. Periodontitis: A risk factor for coronary heart disease?. Ann Periodontol 1998;3:127-141.
9. Chiu B. Multiple infections in carotid atherosclerotic plaques. Am Heart J 1999;138:S534-536.
10. Furuichi Y, Shimotsu A, Ito H, Namariyama Y, Yotsumoto Y, Hino Y, Mishige Y, Inoue M, Izumi Y. Associations of periodontal status with general health conditions and serum antibody titers for Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. J Periodontol 2003;74:1491-1497.
11. Herzberg MC, Weyer MW. Dental plaque, platelets, and cardiovascular diseases. Ann Periodontol 1998;3:151-160.
12. Kozarov EV, Dorn BR, Shelburne CE, Dunn WA, Jr, Progulske-Fox A. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol 2005;25:e17-18.
13. Mattila KJ, Valtonen VV, Nieminen M, Huttunen JK. Dental infection and the risk of new coronary events: Prospective study of patients with documented coronary artery disease. Clin Infect Dis 1995;20:588-592.
14. Morrison HI, Ellison LF, Taylor GW. Periodontal disease and risk of fatal coronary heart and cerebrovascular diseases. J Cardiovasc Risk 1999;6:7-11.
15. Lourbakos A, Yuan YP, Jenkins AL, Travis J, Andrade-Gordon P, Santulli R, Potempa J, Pike RN. Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: A new trait in microbial pathogenicity. Blood 2001;97:3790-3797.
16. Curtis MA, Macey M, Slaney JM, Howells GL. Platelet activation by Protease I of Porphyromonas gingivalis W83. FEMS Microbiol Lett 1993;110:167-173.
17. Naito M, Sakai E, Shi Y, Ideguchi H, Shoji M, Ohara N, Yamamoto K, Nakayama K. Porphyromonas gingivalis-induced platelet aggregation in plasma depends on Hgp44 adhesin but not Rgp proteinase. Mol Microbiol 2006;59:152-167.
18. Sharma A, Novak EK, Sojar HT, Swank RT, Kuramitsu HK, Genco RJ. Porphyromonas gingivalis platelet aggregation activity: Outer membrane vesicles are potent activators of murine platelets. Oral Microbiol Immunol 2000;15:393-396.
19. Steen VM, Holmsen H, Aarbakke G. The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro. Thromb Haemost 1993;70:506-513.
20. Pham K, Feik D, Hammond BF, Rams TE, Whitaker EJ. Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles. Platelets 2002;13:21-30.
21. von Kanel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol 2000;65:357-369.
22. Yee DL, Bergeron AL, Sun CW, Dong JF, Bray PF. Platelet hyperreactivity generalizes to multiple forms of stimulation. J Thromb Haemost 2006;4:2043-2050.
23. Scazziota A, Altman R, Rouvier J, Gonzalez C, Ahmed Z, Jeske WP, Walenga JM, Fareed J. Abciximab treatment in vitro after aspirin treatment in vivo has additive effects on platelet aggregation, ATP release, and P-selectin expression. Thromb Res 2000;100:479-488.
24. Sils D, Rodgers SE, Lloyd JV, Wilson KM, Siebert DM, Bochner F. Inhibition of platelet aggregation and thromboxane production by low concentrations of aspirin in vitro. Clin Sci (Lond) 1988;74:491-497.
25. Whitaker EJ, Thomas IS, Falk JA, Obebe A, Hammond BF: Effect of acetylsalicylic acid on aggregation of human platelets by Porphyromonas gingivalis. Gen Dent 2007;55:64-69; quiz 70, 7980.
26. Bylund DB, Ray-Prenger C, Murphy TJ. Alpha-2A and alpha-2B adrenergic receptor subtypes: Antagonist binding in tissues and cell lines containing only one subtype. J Pharmacol Exp Ther 1988;245:600-607.
27. Keularts IM, van Gorp RM, Feijge MA, Vuist WM, Heemskerk JW. alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. J Biol Chem 2000;275:1763-1772.
28. Aktories K, Jakobs KH. Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes via alpha-adrenoceptors. FEBS Lett 1981;130:235-238.