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Volumn 10, Issue 10, 2008, Pages 2773-2784

Burkholderia cenocepacia strains isolated from cystic fibrosis patients are apparently more invasive and more virulent than rhizosphere strains

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; VIRULENCE FACTOR;

EID: 51749102466     PISSN: 14622912     EISSN: 14622920     Source Type: Journal    
DOI: 10.1111/j.1462-2920.2008.01697.x     Document Type: Article
Times cited : (26)

References (57)
  • 2
    • 1342302530 scopus 로고    scopus 로고
    • The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia
    • Baldwin, A., Sokol, P.A., Parkhill, J. Mahenthiralingam, E. (2004) The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia. Infect Immun 72 : 1537 1547.
    • (2004) Infect Immun , vol.72 , pp. 1537-1547
    • Baldwin, A.1    Sokol, P.A.2    Parkhill, J.3    Mahenthiralingam, E.4
  • 3
    • 24744443523 scopus 로고    scopus 로고
    • Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex
    • Baldwin, A., Mahenthiralingam, E., Thickett, K.M., Honeybourne, D., Maiden, M.C.J., Govan, J.R., et al. (2005) Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. J Clin Microbiol 43 : 4665 4673.
    • (2005) J Clin Microbiol , vol.43 , pp. 4665-4673
    • Baldwin, A.1    Mahenthiralingam, E.2    Thickett, K.M.3    Honeybourne, D.4    Maiden, M.C.J.5    Govan, J.R.6
  • 5
    • 27444437013 scopus 로고    scopus 로고
    • The rhizosphere as a reservoir for opportunistic human pathogenic bacteria
    • Berg, G., Eberl, L. Hartmann, A. (2005) The rhizosphere as a reservoir for opportunistic human pathogenic bacteria. Environ Microbiol 7 : 1673 1685.
    • (2005) Environ Microbiol , vol.7 , pp. 1673-1685
    • Berg, G.1    Eberl, L.2    Hartmann, A.3
  • 6
    • 0036192494 scopus 로고    scopus 로고
    • Burkholderia cepacia complex bacteria from clinical and environmental sources in Italy: Genomovar status and distribution of traits related to virulence and transmissibility
    • Bevivino, A., Dalmastri, C., Tabacchioni, S., Chiarini, L., Belli, M.L., Piana, S., et al. (2002) Burkholderia cepacia complex bacteria from clinical and environmental sources in Italy: genomovar status and distribution of traits related to virulence and transmissibility. J Clin Microbiol 40 : 846 851.
    • (2002) J Clin Microbiol , vol.40 , pp. 846-851
    • Bevivino, A.1    Dalmastri, C.2    Tabacchioni, S.3    Chiarini, L.4    Belli, M.L.5    Piana, S.6
  • 7
    • 22544462496 scopus 로고    scopus 로고
    • Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model
    • Bragonzi, A., Worlitzsch, D., Pier, G.B., Timpert, P., Ulrich, M., Hentzer, M., et al. (2005) Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model. J Infect Dis 192 : 410 419.
    • (2005) J Infect Dis , vol.192 , pp. 410-419
    • Bragonzi, A.1    Worlitzsch, D.2    Pier, G.B.3    Timpert, P.4    Ulrich, M.5    Hentzer, M.6
  • 8
    • 0029835952 scopus 로고    scopus 로고
    • Invasion of respiratory epithelial cells by Burkholderia (Pseudomonas) cepacia
    • Burns, J.L., Jonas, M., Chi, E.Y., Clark, D.K., Berger, A. Griffith, A. (1996) Invasion of respiratory epithelial cells by Burkholderia (Pseudomonas) cepacia. Infect Immun 64 : 4054 4059.
    • (1996) Infect Immun , vol.64 , pp. 4054-4059
    • Burns, J.L.1    Jonas, M.2    Chi, E.Y.3    Clark, D.K.4    Berger, A.5    Griffith, A.6
  • 9
    • 0034793386 scopus 로고    scopus 로고
    • Common mechanisms for pathogens of plants and animals
    • Cao, H., Baldini, R.L. Rahme, L.G. (2001) Common mechanisms for pathogens of plants and animals. Annu Rev Phytopathol 39 : 259 284.
    • (2001) Annu Rev Phytopathol , vol.39 , pp. 259-284
    • Cao, H.1    Baldini, R.L.2    Rahme, L.G.3
  • 13
    • 33744827981 scopus 로고    scopus 로고
    • Burkholderia cepacia complex species: Health hazards and biotechnological potential
    • Chiarini, L., Bevivino, A., Dalmastri, C., Tabacchioni, S. Visca, P. (2006) Burkholderia cepacia complex species: health hazards and biotechnological potential. Trends Microbiol 14 : 277 286.
    • (2006) Trends Microbiol , vol.14 , pp. 277-286
    • Chiarini, L.1    Bevivino, A.2    Dalmastri, C.3    Tabacchioni, S.4    Visca, P.5
  • 14
    • 0034948977 scopus 로고    scopus 로고
    • Invasion of murine respiratory epithelial cells in vivo by Burkholderia cepacia
    • Chiu, C.-H., Ostry, A. Speert, D.P. (2001) Invasion of murine respiratory epithelial cells in vivo by Burkholderia cepacia. J Med Microbiol 50 : 594 601.
    • (2001) J Med Microbiol , vol.50 , pp. 594-601
    • Chiu, C.-H.1    Ostry, A.2    Speert, D.P.3
  • 15
    • 0036175183 scopus 로고    scopus 로고
    • Correlation between an in vitro invasion assay and a murine model of Burkholderia cepacia lung infection
    • Cieri, M.V., Mayer-Hamblett, N., Griffith, A. Burns, J.L. (2002) Correlation between an in vitro invasion assay and a murine model of Burkholderia cepacia lung infection. Infect Immun 70 : 1081 1086.
    • (2002) Infect Immun , vol.70 , pp. 1081-1086
    • Cieri, M.V.1    Mayer-Hamblett, N.2    Griffith, A.3    Burns, J.L.4
  • 16
    • 0041350484 scopus 로고    scopus 로고
    • Diversity and significance of Burkholderia species occupying diverse ecological niches
    • Coenye, T. Vandamme, P. (2003) Diversity and significance of Burkholderia species occupying diverse ecological niches. Environ Microbiol 5 : 719 729.
    • (2003) Environ Microbiol , vol.5 , pp. 719-729
    • Coenye, T.1    Vandamme, P.2
  • 17
    • 0020334316 scopus 로고
    • Analysis of covariance using the rank transformation
    • Conover, W.J. Iman, R.L. (1982) Analysis of covariance using the rank transformation. Biometris 38 : 715 724.
    • (1982) Biometris , vol.38 , pp. 715-724
    • Conover, W.J.1    Iman, R.L.2
  • 18
    • 34250217765 scopus 로고    scopus 로고
    • Investigating Burkholderia cepacia complex populations recovered from Italian maize rhizosphere by multilocus sequence typing
    • Dalmastri, C., Baldwin, A., Tabacchioni, S., Bevivino, A., Mahenthiralingam, E., Chiarini, L. Dowson, C. (2007) Investigating Burkholderia cepacia complex populations recovered from Italian maize rhizosphere by multilocus sequence typing. Environ Microbiol 9 : 1632 1639.
    • (2007) Environ Microbiol , vol.9 , pp. 1632-1639
    • Dalmastri, C.1    Baldwin, A.2    Tabacchioni, S.3    Bevivino, A.4    Mahenthiralingam, E.5    Chiarini, L.6    Dowson, C.7
  • 19
  • 20
    • 33748558093 scopus 로고    scopus 로고
    • Differences in invasion and translocation of Burkholderia cepacia complex species in polarised lung epithelial cells in vitro
    • Duff, C., Murphy, P.G., Callaghan, M. McClean, S. (2006) Differences in invasion and translocation of Burkholderia cepacia complex species in polarised lung epithelial cells in vitro. Microb Pathog 41 : 183 192.
    • (2006) Microb Pathog , vol.41 , pp. 183-192
    • Duff, C.1    Murphy, P.G.2    Callaghan, M.3    McClean, S.4
  • 22
    • 0022550728 scopus 로고
    • Pseudomonas cepacia- fatal pulmonary infection in a patient with cystic fibrosis
    • Glass, S. Govan, J.R.W. (1986) Pseudomonas cepacia- fatal pulmonary infection in a patient with cystic fibrosis. J Infect 13 : 157 158.
    • (1986) J Infect , vol.13 , pp. 157-158
    • Glass, S.1    Govan, J.R.W.2
  • 23
    • 0029814366 scopus 로고    scopus 로고
    • Microbial pathogenesis in cystic fibrosis: Mucoid Pseudomonas aeruginosa and Burkholderia cepacia
    • Govan, J.R. Deretic, V. (1996) Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60 : 539 574.
    • (1996) Microbiol Rev , vol.60 , pp. 539-574
    • Govan, J.R.1    Deretic, V.2
  • 24
    • 0036066896 scopus 로고    scopus 로고
    • Murine models of chronic Pseudomonas aeruginosa lung infection
    • van Heeckeren, A.M. Schluchter, M.D. (2002) Murine models of chronic Pseudomonas aeruginosa lung infection. Lab Anim 36 : 291 312.
    • (2002) Lab Anim , vol.36 , pp. 291-312
    • Van Heeckeren, A.M.1    Schluchter, M.D.2
  • 25
    • 0031924967 scopus 로고    scopus 로고
    • Burkholderia cepacia produces a hemolysin that is capable of inducing apoptosis and degranulation of mammalian phagocytes
    • Hutchison, M.L., Poxton, I.R. Govan, J.R.W. (1998) Burkholderia cepacia produces a hemolysin that is capable of inducing apoptosis and degranulation of mammalian phagocytes. Infect Immun 66 : 2033 2039.
    • (1998) Infect Immun , vol.66 , pp. 2033-2039
    • Hutchison, M.L.1    Poxton, I.R.2    Govan, J.R.W.3
  • 26
    • 13244267001 scopus 로고    scopus 로고
    • MlstdbNet - Distributed multi-locus sequence typing (MLST) databases
    • Jolley, K.A., Chan, M.S. Maiden, M.C.J. (2004) mlstdbNet - distributed multi-locus sequence typing (MLST) databases. BMC Bioinformatics 5 : 86.
    • (2004) BMC Bioinformatics , vol.5 , pp. 86
    • Jolley, K.A.1    Chan, M.S.2    Maiden, M.C.J.3
  • 27
    • 0037042475 scopus 로고    scopus 로고
    • An epidemic Burkholderia cepacia complex strain identified in soil
    • LiPuma, J.J., Spilker, T., Coenye, T. Gonzalez, C.F. (2002) An epidemic Burkholderia cepacia complex strain identified in soil. Lancet 359 : 2002 2003.
    • (2002) Lancet , vol.359 , pp. 2002-2003
    • Lipuma, J.J.1    Spilker, T.2    Coenye, T.3    Gonzalez, C.F.4
  • 28
    • 27344435290 scopus 로고    scopus 로고
    • Taxonomy and pathogenesis of the Burkholderia cepacia complex
    • Mahenthiralingam, E. Vandamme, P. (2005) Taxonomy and pathogenesis of the Burkholderia cepacia complex. Chron Respir Dis 2 : 209 217.
    • (2005) Chron Respir Dis , vol.2 , pp. 209-217
    • Mahenthiralingam, E.1    Vandamme, P.2
  • 29
    • 0036301602 scopus 로고    scopus 로고
    • Burkholderia cepacia complex infection in patients with cystic fibrosis
    • Mahenthiralingam, E., Baldwin, A. Vandamme, P. (2002) Burkholderia cepacia complex infection in patients with cystic fibrosis. J Med Microbiol 51 : 1 6.
    • (2002) J Med Microbiol , vol.51 , pp. 1-6
    • Mahenthiralingam, E.1    Baldwin, A.2    Vandamme, P.3
  • 30
    • 13444251656 scopus 로고    scopus 로고
    • The multifarious, multireplicon Burkholderia cepacia complex
    • Mahenthiralingam, E., Urban, T.A. Goldberg, J.B. (2005) The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol 3 : 144 156.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 144-156
    • Mahenthiralingam, E.1    Urban, T.A.2    Goldberg, J.B.3
  • 31
    • 44249085887 scopus 로고    scopus 로고
    • Burkholderia cepacia complex bacteria: Opportunistic pathogens with important natural biology
    • Mahenthiralingam, E., Baldwin, A. Dowson, C.G. (2008) Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology. J Appl Microbiol 104 : 1539 1551.
    • (2008) J Appl Microbiol , vol.104 , pp. 1539-1551
    • Mahenthiralingam, E.1    Baldwin, A.2    Dowson, C.G.3
  • 32
    • 16544381651 scopus 로고    scopus 로고
    • Burkholderia cepacia complex in an Italian cystic fibrosis centre: Epidemiology and clinical course of patients infected with different Burkholderia cenocepacia strains
    • Manno, G., Dalmastri, C., Tabacchioni, S., Vandamme, P., Lorini, R., Minicucci, L., et al. (2004) Burkholderia cepacia complex in an Italian cystic fibrosis centre: epidemiology and clinical course of patients infected with different Burkholderia cenocepacia strains. J Clin Microbiol 42 : 1491 1497.
    • (2004) J Clin Microbiol , vol.42 , pp. 1491-1497
    • Manno, G.1    Dalmastri, C.2    Tabacchioni, S.3    Vandamme, P.4    Lorini, R.5    Minicucci, L.6
  • 33
    • 0033964725 scopus 로고    scopus 로고
    • Invasion and intracellular survival of Burkholderia cepacia
    • Martin, D.W. Mohr, C.D. (2000) Invasion and intracellular survival of Burkholderia cepacia. Infect Immun 68 : 24 29.
    • (2000) Infect Immun , vol.68 , pp. 24-29
    • Martin, D.W.1    Mohr, C.D.2
  • 34
    • 34247882810 scopus 로고    scopus 로고
    • Selection of nitrogen-fixing deficient Burkholderia vietnamiensis strains by cystic fibrosis patients: Involvement of nif gene deletions and auxotrophic mutations
    • Menard, A., Monnez, C., Estrada de los Santos, P., Segonds, C., Caballero-Mellado, J., LiPuma, J.J. et al. (2007) Selection of nitrogen-fixing deficient Burkholderia vietnamiensis strains by cystic fibrosis patients: involvement of nif gene deletions and auxotrophic mutations. Environ Microbiol 9 : 1176 1185.
    • (2007) Environ Microbiol , vol.9 , pp. 1176-1185
    • Menard, A.1    Monnez, C.2    Estrada De Los Santos, P.3    Segonds, C.4    Caballero-Mellado, J.5    Lipuma, J.J.6
  • 35
    • 0035025618 scopus 로고    scopus 로고
    • Cellular aspects of Burkholderia cepacia infection
    • Mohr, C.D., Tomich, M. Herfst, C.A. (2001) Cellular aspects of Burkholderia cepacia infection. Microb Infect 3 : 425 435.
    • (2001) Microb Infect , vol.3 , pp. 425-435
    • Mohr, C.D.1    Tomich, M.2    Herfst, C.A.3
  • 36
    • 34249063087 scopus 로고    scopus 로고
    • Biological cost of hypermutation in Pseudomonas aeruginosa strains from patients with cystic fibrosis
    • Montanari, S., Antonio, O., Salerno, P., Mena, A., Bertoni, G., Tümmler, B., et al. (2007) Biological cost of hypermutation in Pseudomonas aeruginosa strains from patients with cystic fibrosis. Microbiology 153 : 1445 1454.
    • (2007) Microbiology , vol.153 , pp. 1445-1454
    • Montanari, S.1    Antonio, O.2    Salerno, P.3    Mena, A.4    Bertoni, G.5    Tümmler, B.6
  • 37
    • 33744818231 scopus 로고    scopus 로고
    • Evolving stealth: Genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections
    • Nguyen, D. Singh, P.K. (2006) Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infections. Proc Natl Acad Sci USA 103 : 8305 8306.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8305-8306
    • Nguyen, D.1    Singh, P.K.2
  • 38
    • 0034794149 scopus 로고    scopus 로고
    • Diversity of the Burkholderia cepacia complex and implications for risk assessment of biological control strains
    • Parke, J.L. Gurian-Sherman, D. (2001) Diversity of the Burkholderia cepacia complex and implications for risk assessment of biological control strains. Annu Rev Phytopathol 39 : 225 258.
    • (2001) Annu Rev Phytopathol , vol.39 , pp. 225-258
    • Parke, J.L.1    Gurian-Sherman, D.2
  • 41
    • 20444435084 scopus 로고    scopus 로고
    • Distribution of Burkholderia cepacia complex species among isolates recovered from persons with or without cystic fibrosis
    • Reik, R., Spilker, T. LiPuma, J.J. (2005) Distribution of Burkholderia cepacia complex species among isolates recovered from persons with or without cystic fibrosis. J Clin Microbiol 43 : 2926 2928.
    • (2005) J Clin Microbiol , vol.43 , pp. 2926-2928
    • Reik, R.1    Spilker, T.2    Lipuma, J.J.3
  • 44
    • 0036074169 scopus 로고    scopus 로고
    • Patterns of epithelial cell invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelia
    • Schwab, U., Leigh, M., Ribeiro, C., Yankaskas, J., Burns, K., Gilligan, P., et al. (2002) Patterns of epithelial cell invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelia. Infect Immun 70 : 4547 4555.
    • (2002) Infect Immun , vol.70 , pp. 4547-4555
    • Schwab, U.1    Leigh, M.2    Ribeiro, C.3    Yankaskas, J.4    Burns, K.5    Gilligan, P.6
  • 45
    • 0023104989 scopus 로고
    • Identification of transposable elements which activate gene expression in Pseudomonas cepacia
    • Scordilis, G.E., Ree, H. Lessie, T.G. (1987) Identification of transposable elements which activate gene expression in Pseudomonas cepacia. J Bacteriol 169 : 8 13.
    • (1987) J Bacteriol , vol.169 , pp. 8-13
    • Scordilis, G.E.1    Ree, H.2    Lessie, T.G.3
  • 46
    • 0023238619 scopus 로고
    • Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudo-tubercolosis, and Yersinia enterocolitica to enter and replicate within Hep-2 cells
    • Small, P.L., Isberg, R.R. Falkow, S. (1987) Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudo-tubercolosis, and Yersinia enterocolitica to enter and replicate within Hep-2 cells. Infect Immun 55 : 1674 1679.
    • (1987) Infect Immun , vol.55 , pp. 1674-1679
    • Small, P.L.1    Isberg, R.R.2    Falkow, S.3
  • 48
    • 0032774756 scopus 로고    scopus 로고
    • Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: Characterization of pvdA, the gene encoding l-ornitithine N(5)-oxygenase
    • Sokol, P.A., Darling, P., Woods, D.E., Mahenthiralingam, E. Kooi, C. (1999) Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: characterization of pvdA, the gene encoding l-ornitithine N(5)-oxygenase. Infect Immun 67 : 4443 4455.
    • (1999) Infect Immun , vol.67 , pp. 4443-4455
    • Sokol, P.A.1    Darling, P.2    Woods, D.E.3    Mahenthiralingam, E.4    Kooi, C.5
  • 49
    • 0035145513 scopus 로고    scopus 로고
    • Understanding Burkholderia cepacia: Epidemiology, genomovars, and virulence
    • Speert, D.P. (2001) Understanding Burkholderia cepacia: epidemiology, genomovars, and virulence. Infect Med 18 : 49 56.
    • (2001) Infect Med , vol.18 , pp. 49-56
    • Speert, D.P.1
  • 50
    • 0036193728 scopus 로고    scopus 로고
    • Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada
    • Speert, D.P., Henry, D., Vandamme, P., Corey, M. Mahenthiralingam, E. (2002) Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada. Emerg Infect Dis 8 : 181 187.
    • (2002) Emerg Infect Dis , vol.8 , pp. 181-187
    • Speert, D.P.1    Henry, D.2    Vandamme, P.3    Corey, M.4    Mahenthiralingam, E.5
  • 51
    • 0023607375 scopus 로고
    • A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia
    • Starke, J.R., Edwards, M.S., Langston, C. Baker, C.J. (1987) A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia. Pediatr Res 22 : 698 702.
    • (1987) Pediatr Res , vol.22 , pp. 698-702
    • Starke, J.R.1    Edwards, M.S.2    Langston, C.3    Baker, C.J.4
  • 52
    • 0037369874 scopus 로고    scopus 로고
    • Attenuated virulence of a Burkholderia cepacia type III secretion mutant in a murine model of infection
    • Tomich, M., Griffith, A., Herfst, C.A., Burns, J.L. Mohr, C.D. (2003) Attenuated virulence of a Burkholderia cepacia type III secretion mutant in a murine model of infection. Infect Immun 71 : 1405 1415.
    • (2003) Infect Immun , vol.71 , pp. 1405-1415
    • Tomich, M.1    Griffith, A.2    Herfst, C.A.3    Burns, J.L.4    Mohr, C.D.5
  • 53
    • 33750964758 scopus 로고    scopus 로고
    • Clonal variations in Pseudomonas aeruginosa
    • In. Ramos, J. Levesque, R.C. (eds). Heidelberg, Germany: Springer, pp.
    • Tümmler, B. (2006) Clonal variations in Pseudomonas aeruginosa. In Pseudomonas, Vol. 4. Ramos, J.-L. Levesque, R.C. (eds). Heidelberg, Germany : Springer, pp. 35 68.
    • (2006) Pseudomonas , vol.4-50 , pp. 35-68
    • Tümmler, B.1
  • 54
    • 13444287893 scopus 로고    scopus 로고
    • Survival and persistence of opportunistic Burkholderia species in host cells
    • Valvano, M.A., Keith, K.E. Cardona, S.T. (2005) Survival and persistence of opportunistic Burkholderia species in host cells. Curr Opin Microbiol 8 : 99 105.
    • (2005) Curr Opin Microbiol , vol.8 , pp. 99-105
    • Valvano, M.A.1    Keith, K.E.2    Cardona, S.T.3
  • 55
    • 34047116370 scopus 로고    scopus 로고
    • Molecular mechanisms of pathogenicity: How do pathogenic microorganisms develop cross-kingdom host jumps?
    • Van Baarlen, P., van Belkum, A., Summerbell, R.C., Crous, P.W. Thomma, B.P.H.J. (2007) Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps? FEMS Microbiol Rev 31 : 239 277.
    • (2007) FEMS Microbiol Rev , vol.31 , pp. 239-277
    • Van Baarlen, P.1    Van Belkum, A.2    Summerbell, R.C.3    Crous, P.W.4    Thomma, B.P.H.J.5
  • 57
    • 0036167851 scopus 로고    scopus 로고
    • Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
    • Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekici, A., Meyer, K.C., et al. (2002) Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 109 : 317 325.
    • (2002) J Clin Invest , vol.109 , pp. 317-325
    • Worlitzsch, D.1    Tarran, R.2    Ulrich, M.3    Schwab, U.4    Cekici, A.5    Meyer, K.C.6


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