eIF4E-Targeted Suicide Gene Therapy in a Minimal Residual Mouse Model for Metastatic Soft-Tissue Head and Neck Squamous Cell Carcinoma Improves Disease-Free Survival

Journal of Surgical Research

Volumn 148, Issue 1, 2008, Pages 83-89

  Siegele, Bradford ^a   Cefalu, Christopher ^a   Holm, Neal ^a   Sun, Guang ^a   Tubbs, Jesse ^a   Meschonat, Carol ^a   Odaka, Yoshinobu ^a   DeBenedetti, Arrigo ^a   Ghali, G E ^a   Chu, Quyen ^a   Michael Mathis, J ^a   Li, Benjamin D L ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

adenovirus; cytoreductive; eIF4E; head and neck cancer; squamous cell carcinoma

Indexed keywords

ADENOVIRUS VECTOR; GANCICLOVIR; HERPESVIRUS VECTOR; INITIATION FACTOR 4E; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; C3H MOUSE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOREDUCTIVE SURGERY; CYTOTOXICITY; DISEASE FREE SURVIVAL; DRUG EFFICACY; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; MINIMAL RESIDUAL DISEASE; MOUSE; NONHUMAN; NULL ALLELE; OVERALL SURVIVAL; PRIORITY JOURNAL; SOFT TISSUE CANCER; SOFT TISSUE METASTASIS; SQUAMOUS CELL CARCINOMA; SUICIDE GENE; SUICIDE GENE THERAPY; TUMOR GROWTH;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DISEASE-FREE SURVIVAL; EUKARYOTIC INITIATION FACTOR-4E; GENE THERAPY; GENES, TRANSGENIC, SUICIDE; GENETIC VECTORS; HEAD AND NECK NEOPLASMS; MICE; MICE, INBRED C3H; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL;

EID: 51749091546     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.03.011     Document Type: Article

References (23)

1. Forastiere A., Koch W., Trotti A., et al. Head and neck cancer. N Engl J Med 345 (2001) 1890
2. In: Ries L.A.G., Melbert D., Krapcho M., et al. (Eds). SEER Cancer Statistics Review, 1975-2004 (2007), National Cancer Institute, Bethesda, MD
3. American Cancer Society. Cancer Facts & Figures 2007. Atlanta, GA: American Cancer Society.
4. Xi S., and Grandis J.R. Gene therapy for the treatment of oral squamous cell carcinoma. J Dent Res 82 (2003) 11
5. Ganly I., Kirn D., Eckhardt G., et al. A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin Cancer Res 6 (2000) 798
6. Lamont J.P., Nemunaitis J., Kuhn J.A., et al. A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience). Ann Surg Oncol 7 (2000) 588
7. Liu B.L., Robinson M., Han S.Q., et al. ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther 10 (2003) 292
8. Zhu B.B., Mathis J.M., Makhija S.K., et al. Targeting of a conditionally replicative adenovirus agent to human squamous cell carcinomas of the head and neck. Int J Oncol 31 (2007) 1213
9. O'Malley B.W., Chen S.H., Schwartz M.R., et al. Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model. Cancer Res 55 (1995) 1080
10. O'Malley B.W., Cope K.A., Chen S.H., et al. Combination gene therapy for oral cancer in a murine model. Cancer Res 56 (1996) 1737
11. Nishikawa M., Hayashi Y., Yamamoto N., et al. Cell death of human oral squamous cell carcinoma cell line induced by thymidine kinase gene and ganciclovir. Nagoya J Med Sci 66 (2003) 129
12. Mathis J.M., Williams B.J., Sibley D.A., et al. Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control. J Gene Med 8 (2006) 1105
13. Byrnes K., Li B.D.L., Holm N., et al. A novel suicide gene therapy targeting the overexpression of eukaryotic initiation factor 4E improves survival in a rat peritoneal carcinomatosis model. Surgery 142 (2007) 270
14. Chu Q.D., and Li B.D.L. A restricted HSV-TK/GCV gene increases disease-free and overall survival in a minimal residual rat breast cancer model. J Surg Res 121 (2004) 280 (abstract)
15. DeFatta R.J., Li Y., and De Benedetti A. Selective killing of cancer cells based on translational control of a suicide gene. Cancer Gene Ther 9 (2002) 573
16. DeFatta R.J., Chervenak R.P., and De Benedetti A. A cancer gene therapy approach through translational control of a suicide gene. Cancer Gene Ther 9 (2002) 505
17. Rhoads R.E. Regulation of eukaryotic protein synthesis by initiation factors. J Biol Chem 268 (1993) 3017
18. Scott P.A., Smith K., Poulsom R., et al. Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E. Br J Cancer 77 (1998) 2120
19. Rosenwald I.B., Lazaris-Karatzas A., Sonenberg N., et al. Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol 13 (1993) 7358
20. Sorrells D.L., Ghali G.E., Meschonat C., et al. Competitive PCR to detect eIF4E gene amplification in head and neck cancer. Head Neck 21 (1999) 60
21. Carroll J.L., Nielsen L.L., Pruett S.B., et al. The role of natural killer cells in adenovirus-mediated p53 gene therapy. Mol Cancer Ther 1 (2002) 49
22. Li B.D.L., McDonald J.C., Nassar R., et al. Clinical outcome in stage I to III breast cancer and eIF4E overexpression. Ann Surg 227 (1998) 756
23. Menezes C., De Benedetti A., and Abreo F. A survey of the protooncogene/translation factor eIF-4E in head and neck squamous cell cancers. Otolaryngol Head Neck Surg 115 (1996) P72 (abstract)