PILAR is a novel modulator of human T-cell expansion

Blood

Volumn 112, Issue 4, 2008, Pages 1259-1268

  Huarte, Eduardo ^a   Cubillos Ruiz, Juan R ^a   Nesbeth, Yolanda C ^a   Scarlett, Uciane K ^a   Martinez, Diana G ^a   Engle, Xavier A ^a   Rigby, William F ^a   Pioli, Patricia A ^a   Guyre, Paul M ^a   Conejo Garcia, Jose R ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b HB 7556   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD161 ANTIGEN; CD3 ANTIBODY; PROLIFERATION INDUCED LYMPHOCYTE ASSOCIATED RECEPTOR; PROTEIN BCL XL; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CLEC2A PROTEIN, HUMAN; KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY B; KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; LECTIN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN;

APOPTOSIS; ARTHRITIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; AUTOIMMUNE DISEASE; CELL CULTURE; CELLULAR IMMUNITY; CHEMISTRY; CHROMOSOME 12; CYTOLOGY; FEMALE; GENETICS; IMMUNOLOGY; INFLAMMATION; LYMPHOCYTE ACTIVATION; METABOLISM; OVARY TUMOR; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; T LYMPHOCYTE; UPREGULATION;

ANTIGENS, SURFACE; AUTOIMMUNE DISEASES; CELL PROLIFERATION; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 12; FEMALE; HUMANS; IMMUNITY, CELLULAR; INFLAMMATION; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; OVARIAN NEOPLASMS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; T-LYMPHOCYTES; UP-REGULATION;

EID: 51649131274     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-12-130773     Document Type: Article

References (27)

1. Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol. 2002;20:29-53.
2. Thompson CB, Lindsten T, Ledbetter JA, et al. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci USA. 1989; 86:1333-1337.
3. Conejo-Garcia JR. Benencia F. Courreges MC, et al. Ovarian carcinoma expresses the NKG2D li- gand Letal and promotes the survival and expansion of CD28- antitumor T cells. Cancer Res. 2004;64:2175-2182.
4. Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T. Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIG induced on virus-infected cells. Nat Immunol. 2001;2:255-260.
5. Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol. 2005;23:23-68.
6. Kahn ML, Koretzky GA. Integrins and ITAMs: more than just good neighbors. Nat Immunol. 2006;7:1286-1288.
7. Swain SL. CD4 T cell development and cytokine polarization: an overview. J Leukoc Biol. 1995;57: 795-798.
8. Boyman O, Kovar M, Rubinstein MR Surh CD, Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science. 2006;311:1924-1927.
9. Borst J, Hendriks J, Xiao Y. CD27 and CD70 in T cell and B cell activation. Curr Opin Immunol. 2005;17:275-281.
10. Huang J, Kerstann KW, Ahmadzadeh M, et al. Modulation by IL-2 of CD70 and CD27 expression on CD8 + Tcells: importance forthethera-peutic effectiveness of cell transfer immunotherapy. J Immunol. 2006;176:7726-7735.
11. Stephan MT, Ponomarev V. Brentjens RJ, et al. T cell-encoded CD80 and 4-1BBL induce auto-and transcostimulation, resulting in potent tumor rejection. Nat Med. 2007;13:1440-1449.
12. Takahashi T, Dejbakhsh-Jones S. Strober S. Expression of CD161 (NKR-P1 A) defines subsets of human CD4and CDS T cells with different functional activities. J Immunol. 2006;176:211-216.
13. Aldemir H, Prod'homme V, Dumaurier MJ. et al. Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor. J Immunol. 2005;175:7791- 7795.
14. Poggi A, Rubartelli A, Moretta L, Zocchi MR. Expression and function of NKRP1A molecule on human monocytes and dendritic cells. Eur J Immunol. 1997;27:2965-2970.
15. Rosen DB, Bettadapura J, Alsharifi M, Mathew PA. Warren HS. Lanier LL. Cutting edge: lectin- like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. J Immunol. 2005;175: 7796-7799.
16. Maus MV, Thomas AK. Leonard DG, et al. Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat Biotechnol. 2002;20:143-148.
17. Suhoski MM, Golovina TN, Aqui NA, et al. Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules. Mol Ther. 2007;15:981-988.
18. Sancho D, Gomez M, Sanchez-Madrid F. CD69 is an immunoregulatory molecule induced following activation. Trends Immunol. 2005;26:136-140.
19. Cham CM, Xu H, O'Keefe JP, Rivas FV, Zagouras P, Gajewski TF. Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation. J Biol Chem. 2003;278:17044-17052.
20. Scheu S, Stetson DB, Reinhardt RL Leber JH, Mohrs M, Locksley RM. Activation of the integrated stress response during T helper cell differentiation. Nat Immunol. 2006;7:644-651.
21. Mao X, Green JM, Safer B, et al. Regulation of translation initiation factor gene expression during human Tcell activation. J Biol Ghem. 1992; 267:20444-20450.
22. Tahvanainen J, Pykalainen M, Kallonen T, Lahteenmaki H, Rasool O, Lahesmaa R. Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation. J Immunol Methods. 2006; 310:30-39.
23. Sperling Al, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA. GD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J Immunol. 1996;157:3909-3917.
24. Currier JR, Kuta EG, Turk E, et al. A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays. J Immunol Methods. 2002;260:157-172.
25. Sato E, Olson SH, Ahn J, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA. 2005;102:18538-18543.
26. Raghavan A, Ogilvie RL, Reilly C, et al. Genome- wide analysis of mRNA decay in resting and activated primary human T lymphocytes. Nucleic Acids Res. 2002;30:5529-5538.
27. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-678.