Identification of multiple post-translational modifications in the porcine brain specific p25α

Journal of Neurochemistry

Volumn 106, Issue 2, 2008, Pages 925-933

  Kjeinnijenhuis, Anne J ^a,d   Hedegaard, Claus ^b   Lundvig, Ditte ^c   Sundbye, Sabrina ^c   Issinger, Olaf Georg ^a   Jensen, Ole Nørregaard ^a   Jensen, Poul Henning ^c  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d TNO   (Netherlands)

Author keywords

Citrullination; Methylation; O glycosylation; Oligodendrocyte; P25 ; Phosphorylation

Indexed keywords

PHOSPHOPROTEIN; PROTEIN P25ALPHA; UNCLASSIFIED DRUG; NERVE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN; LIQUID CHROMATOGRAPHY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SWINE; TANDEM MASS SPECTROMETRY; TRANSLATION REGULATION; ANIMAL; CHROMOSOME MAP; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

SUS;

ANIMALS; BRAIN; CHROMOSOME MAPPING; CLONING, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SWINE; TANDEM MASS SPECTROMETRY;

EID: 51649129138     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05437.x     Document Type: Article

References (37)

1. Acevedo K., Li R., Soo P., Suryadinata R., Sarcevic B., Valova V. A., Graham M. E., Robinson P. J. and Bernard O. (2007) The phos-phorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp. Cell Res. 313, 4091-4106.
2. Anderson J. P., Walker D. E., Goldstein J. M. et al. (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J. Biol. Chem. 281, 29739-29752.
3. Aramini J. M., Rossi P., Shastry R. et al. (2007) Solution NMR structure of tubulin polymerization-promoting protein family member 3 from Homo sapiens. http://www.pdb.org/pdb/explore/explore.do? structureId=2JRF
4. Baker K. G., Huang Y., McCann H., Gai W. P., Jensen P. H. and Halliday G. M. (2006) P25alpha immunoreactive but alpha-synuclein im- munonegative neuronal inclusions in multiple system atrophy. Acta Neuropathol. 111, 193-195.
5. Fujiwara H., Hasegawa M., Dohmae N., Kawashima A., Masliah E., Goldberg M. S., Shen J., Takio K. and Iwatsubo T. (2002) Phos-phorylated alpha-synuclein is ubiquitinated in alpha-synucleino- pathy lesions. Nat. Cell Biol. 4, 160-164.
6. Gobom J., Nordhoff E., Mirgorodskaya E., Ekman R. and Roepstorff P. (1999) Sample purification and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser desorption/ionization mass spectrometry. J. Mass Spectrom. 34, 105-116.
7. Goldbaum O., Jensen P. H. and Richter-Landsberg C.(2008) The tubulin polymerization promoting protein TPPP/p25α is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress. Glia (In press).
8. Gorbatyuk O. S., Li S., Sullivan L. F., Chen W., Kondrikova G., Manfredsson F. P., Mandel R. J. and Muzyczka N. (2008) The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc. Natl Acad. Sci. USA 105, 763-768.
9. Gyorgy B., Toth E., Tarcsa E., Falus A. and Buzas E. I. (2006) Citrul- lination: a posttranslational modification in health and disease. Int. J. Biochem.Cell Biol. 38, 1662-1677.
10. Hlavanda E., Kovacs J., Olah J., Orosz F., Medzihradszky K. F. and Ovadi J. (2002) Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at sub- stoichiometric concentrations. Biochemistry 41, 8657-8664.
11. Hlavanda E., Klement E., Kokai E., Kovacs J., Vincze O., Tokesi N., Orosz F., Medzihradszky K. F., Dombradi V. and Ovadi J. (2007) Phosphorylation blocks the activity of tubulin polymerization- promoting protein (TPPP): identification of sites targeted by different kinases J. Biol. Chem. 282, 29531-29539.
12. Iwabata H., Yoshida M. and Komatsu Y. (2005) Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies. Proteomics 5, 4653-4664.
13. Jellinger K. A. (2006) P25alpha immunoreactivity in multiple system atrophy and Parkinson disease. Acta Neuropathol. 112, 112.
14. Kleinnijenhuis A. J., Duursma M. C., Breukink E., Heeren R. M. A. and Heck A. J. R. (2003) Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation. Anal. Chem. 75, 3219-3225.
15. Kobayashi N., Koshiba S., Inoue M., Kigawa T. and Yokoyama S.(2005) Solution Structure of Mouse CGI-38 Protein http://www.pdb.org/ pdb/explore/explore.do?structureId=1WLM
16. Kovacs G. G., Laszlo L., Kovacs J. et al. (2004) Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol. Dis. 17, 155-162.
17. Kovacs G. G., Gelpi E., Lehotzky A., Hoftberger R., Erdei A., Budka H. and Ovadi J. (2007) The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases. Acta Neuropathol. 113, 153-161.
18. Lehotzky A., Tirian L., Tokesi N., Lenart P., Szabo B., Kovacs J. and Ovadi J. (2004) Dynamic targeting of microtubules by TPPP/p25 affects cell survival J. Cell Sci. 117, 6249-6259.
19. Lindersson E., Lundvig D., Petersen C. et al. (2005) p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. J. Biol Chem. 280, 5703-5715.
20. Martin C. P., Vazquez J., Avila J. and Moreno F. J. (2002) P24, a glycogen synthase kinase 3 (GSK 3) inhibitor. Biochim. Biophys. Acta 1586, 113-122.
21. Monleon D., Chiang Y., Aramini J. M., Swapna G. V., Macapagal D., Gunsalus K. C., Kim S., Szyperski T. and Montelione G. T. (2004) Backbone 1H, 15N and 13C assignments for the 21 kDa Caenor- habditis elegans homologue of 'brain-specific' protein. J. Biomol. NMR 28, 91-92.
22. Musse A. A. and Harauz G. (2006) A tale of two citrullines-structural and functional aspects of myelin basic protein deimination in health and disease. Neurochem. Res. 32, 137-158.
23. Olah J., Tokesi N., Vincze O. et al. (2006) Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. FEBS Lett. 580, 5807-5814.
24. Orosz F., Kovacs G. G., Lehotzky A., Olah J., Vincze O. and Ovadi J. (2004) TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments. Biol Cell 96, 701-711.
25. Otzen D. E., Lundvig D. M., Wimmer R., Nielsen L. H., Pedersen J. R. and Jensen P. H. (2005) p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry. Protein Sci. 14, 1396-1409.
26. Polevoda B. and Sherman F. (2007) Methylation of proteins involved in translation. Mol. Microbiol. 65, 590-606.
27. Shi Y., Lan F., Matson C., Mulligan P., Whetstine J. R., Cole P. A., Casero R. A. and Shi Y. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953.
28. Skjoerringe T., Lundvig D. M., Jensen P. H. and Moos T. (2006) P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. J.Neurochem. 99, 333-342.
29. Song Y. J., Lundvig D. M., Huang Y., Gai W. P., Blumbergs P. C., Hojrup P., Otzen D., Halliday G. M. and Jensen P. H. (2007) p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. Am. J. Pathol. 171, 1291-1303.
30. Stensballe A. and Jensen O. N. (2004) Phosphoric acid enhances the performance of Fe(III) affinity chromatography and matrix-assisted laser desorption/ionization tandem mass spectrometry for recovery, detection and sequencing of phosphopeptides. Rapid Commun. Mass Spectrom. 18, 1721-1730.
31. Stoothoff W. H. and Johnson G. V. (2005) Tau phosphorylation: physiological and pathological consequences. Biochim. Biophys. Acta 1739, 280-297.
32. Takahashi M., Tomizawa K., Ishiguro K., Sato K., Omori A., Sato S., Shiratsuchi A., Uchida T. and Imahori K. (1991) A novel brain- specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions. FEBS Lett. 289, 37-43.
33. Takahashi M., Tomizawa K., Fujita S. C., Sato K., Uchida T. and Imahori K. (1993) A brain-specific protein p25 is localized and associated with oligodendrocytes, neuropil, and fiber-like structures of the CA3 hippocampal region in the rat brain. J. Neurochem. 60, 228-235.
34. Tirian L., Hlavanda E., Olah J., Horvath I., Orosz F., Szabo B., Kovacs J., Szabad J. and Ovadi J. (2003) TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. Proc. Natl Acad. Sci. USA 100, 13976-13981.
35. Vincze O., Tokesi N., Olah J. et al. (2006) Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry 45, 13818-13826.
36. Vosseller K., Trinidad J. C., Chalkley R. J. et al. (2006) O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry Mol. Cell Proteomics 5, 923-934.
37. Yokozeki T., Homma K., Kuroda S., Kikkawa U., Ohno S., Takahashi M., Imahori K. and Kanaho Y. (1998) Phosphatidic acid-dependent phosphorylation of a 29-kDa protein by protein kinase Calpha in bovine brain cytosol. J. Neurochem. 71, 410-417.