Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystals

Pharmaceutical Research

Volumn 25, Issue 10, 2008, Pages 2283-2291

  Murnane, Darragh ^a   Martin, Gary P ^a   Marriott, Christopher ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Aggregation; Fluticasone propionate; Metered dose inhaler; Microcrystals; Salmeterol xinafoate; Suspension

Indexed keywords

FLUORINATED HYDROCARBON; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; MACROGOL; PROPELLANT; SALMETEROL XINAFOATE;

AEROSOL; ARTICLE; CORRELATION ANALYSIS; CRYSTAL; DRUG FORMULATION; METERED DOSE INHALER; MICRONIZATION; PRIORITY JOURNAL; SUSPENSION;

ADMINISTRATION, INHALATION; AEROSOL PROPELLANTS; AEROSOLS; ALBUTEROL; ANDROSTADIENES; BRONCHODILATOR AGENTS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG STABILITY; HYDROCARBONS, FLUORINATED; METERED DOSE INHALERS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; PRESSURE; REPRODUCIBILITY OF RESULTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 51649117524     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9622-3     Document Type: Article

References (29)

1. R. Dalby J. Suman 2003 Inhalation therapy: technological milestones in asthma treatment Adv. Drug Del. Rev 55 779 791
2. J. N. Pritchard 2001 The influence of lung deposition on clinical response J. Aerosol Med 14 S19 S26
3. J. Berry S. Heimbecher J. L. Hart J. Sequeira 2003 Influence of the metering chamber volume and actuator design on the aerodynamic particle size of a metered dose inhaler Drug Dev. Ind. Pharm 29 865 876
4. G. Brambilla D. Ganderton R. Garzia D. Lewis B. Meakin P. Ventura 1999 Modulation of aerosol clouds produced by pressurised inhalation aerosols Int. J. Pharm 186 53 61
5. C. Vervaet P. R. Byron 1999 Drug-surfactant-propellant interactions in HFA-formulations Int. J. Pharm 186 13 30
6. H. D. C. Smyth 2003 The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers Adv. Drug Del. Rev 55 807 828
7. I. Gonda 1985 Development of a systematic theory of suspension inhalation aerosols. I. A framework to study the effects of aggregation on the aerodynamic behaviour of drug particles Int. J. Pharm 27 99 116
8. C. Hak-Kim I. Gonda 1988 Development of a systematic theory of suspension inhalation aerosols. II. Aggregates of monodisperse particles nebulized in polydisperse droplets Int. J. Pharm 41 147 157
9. T. E. Tarara M. S. Hartman H. Gill A. A. Kennedy J. G. Weers 2004 Characterization of suspension-based metered dose inhaler formulations composed of spray-dried budesonide microcrystals dispersed in HFA-134a Pharm. Res 21 1607 1614
10. Y. Michael B.Z. Chowdhry I.C. Ashurst M.J. Snowden C. Davies-Cutting S. Gray 2000 The physico-chemical properties of salmeterol and fluticasone propionate in different solvent environments Int. J. Pharm 200 279 288
11. J. Berry L. Kline V. Naini S. Chaudhry J. Hart J. Sequeira 2004 Influence of the valve lubricant on the aerodynamic particle size of a metered dose inhaler Drug Dev. Ind. Pharm 30 267 275
12. I. D. Peyron I. L. Britto L. B. Benissan B. Z. Tardieu 2005 Development and performance of a new hydrofluoroalkane (HFA 134a)-based metered dose inhaler (MDI) of salmeterol Respir. Med 99 S20 S30
13. R. Ashayer P. F. Luckham S. Manimaaran P. Rogueda 2004 Investigation of the molecular interactions in a pMDI formulation by atomic force microscopy Eur. J. Pharm. Sci 21 533 543
14. A. Cripps M. Riebe M. Schulze R. Woodhouse 2000 Pharmaceutical transition to non-CFC pressurized metered dose inhalers Respir. Med 94 S3 S9
15. Y. Michael M. J. Snowden B. Z. Chowdhry I. C. Ashurst C. J. Davies-Cutting T. Riley 2001 Characterisation of the aggregation behaviour in a salmeterol and fluticasone propionate inhalation aerosol system Int. J. Pharm 221 165 174
16. G. Buckton 1997 Characterisation of small changes in the physical properties of powders of significance for dry powder inhaler formulations Adv. Drug Del. Rev 26 17 27
17. M. Davies A. Brindley X. Y. Chen M. Marlow S. W. Doughty I. Shrubb C. J. Roberts 2005 Characterization of drug particle surface energetics and Young's modulus by atomic force microscopy and inverse gas chromatography Pharm. Res 22 1158 1166
18. E. M. Phillips P. R. Byron 1994 Surfactant promoted crystal growth of micronized methylprednisolone in trichloromonofluoromethane Int. J. Pharm 110 9 19
19. D. Murnane C. Marriott G. P. Martin 2008 Comparison of salmeterol xinafoate microparticle production by conventional and novel antisolvent crystallization Eur. J. Pharm. Biopharm 69 94 105
20. D. Murnane G. P. Martin C. Marriott 2006 Validation of a reverse-phase high performance liquid chromatographic method for concurrent assay of a weak base (salmeterol xinafoate) and a pharmacologically active steroid (fluticasone propionate) J. Pharm. Biomed. Anal 40 1149 1154
21. S. A. Jones G. P. Martin M. B. Brown 2005 High-pressure aerosol suspensions-a novel laser diffraction particle sizing system for hydrofluoroalkane pressurised metered dose inhalers Int. J. Pharm 302 154 165
22. British Pharmacopoeia, The Stationary Office, London, 2007.
23. B. Y. Shekunov J. C. Feeley A. H. L. Chow H. H. Y. Tong P. York 2002 Physical properties of supercritically-processed and micronised powders for respiratory drug delivery KONA 20 178 187
24. M. D. Louey M. Van Oort A. J. Hickey 2004 Aerosol dispersion of respirable particles in narrow size distributions using drug-alone and lactose-blend formulations Pharm. Res 21 1207 1213
25. D. Murnane, C. Marriott and G. P. Martin. Crystallization and crystallinity of fluticasone propionate. Crys. Growth Des. (2008), (in press).
26. P. M. Young R. Price D. Lewis S. Edge D. Traini 2003 Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope J. Colloid Interface Sci 262 298 302
27. S. A. Jones G. P. Martin M. B. Brown 2006 Manipulation of beclomethasone-hydrofluoroalkane interactions using biocompatible macromolecules J. Pharm. Sci 95 1060 1074
28. H. H. Y. Tong B. Y. Shekunov P. York A. H. L. Chow 2002 Influence of polymorphism on the surface energetics of salmeterol xinafoate crystallized from supercritical fluids Pharm. Res 19 640 648
29. H. Steckel B. W. Muller 1998 Metered-dose inhaler formulation of fluticasone-17-propionate micronized with supercritical carbon dioxide using the alternative propellant HFA-227 Int. J. Pharm 173 25 33