Metered-dose inhaler formulation of fluticasone-17-propionate micronized with supercritical carbon dioxide using the alternative propellant HFA-227

International Journal of Pharmaceutics

Volumn 173, Issue 1-2, 1998, Pages 25-33

  Steckel, Hartwig ^a   Müller, Bernd W ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Aerosol formulation; ASES; CFC free; Fine particle fraction; Fluticasone 17 propionate; HFA 227; Twin stage impinger

Indexed keywords

APAFLURANE; CARBON DIOXIDE; FLUTICASONE PROPIONATE; PHOSPHATIDYLCHOLINE; POLOXAMER; TRIACETIN; TRIOLEIN;

AEROSOL; ARTICLE; DRUG FORMULATION; METERED DOSE INHALER; PRIORITY JOURNAL;

EID: 0345251959     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00237-3     Document Type: Article

References (23)

1. Aerosol Consensus Statement, 1991. Chest 100, 1106-1109.
2. Barnes, P.J., 1995. Inhaled glucocorticoids for asthma. New Engl. J. Med. 332, 868-875.
3. Beyer, C., Maasz, J., 1987. Röntgendiffraktometrie in der Pharmazie. Pharm. Unserer Zeit 16, 12-29.
4. Boyd, G., 1995. The continued need for metered-dose inhalers. J. Aerosol Med. 8 (Suppl. 1), 9-12.
5. British Pharmacopeia, 1993. British Pharmacopeia Commission, London.
6. Byron, P.R., Miller, N.C., Blondino, F.E., Visich, J.E., Ward, G.H., 1994. Some aspects of alternative propellant solvency. Respir. Drug Del. IV, 231-242.
7. Dixon, D.J., Johnston, K.P., Bodmeier, R.A., 1993. Polymeric materials formed by precipitation with a compressed fluid antisolvent. AIChE J. 39, 127-139.
8. Elvecrog, J., 1997. Metered-dose inhalers in a CFC free future. Pharm. Technol. Eur. 9 (1), 52-55.
9. Gallagher-Wetmore, P., Coffey, M.P., Krukonis, V., 1994. Applications of supercritical fluids in recrystallization: nucleation and gas antisolvent techniques. Respir. Drug Del. IV, 287-295.
10. Hickey, A.J., Evans, R.M., 1996. Aerosol generation from propellant driven metered dose inhalers. In: Hickey, A.J. (Ed.), Inhalation Aerosols: Physical and Biological Basis for Therapy. Marcel Dekker, New York, pp. 417-439.
11. Jenkins, M., 1995. Clinical evaluation of CFC free metered-dose inhalers. J. Aerosol Sci. 8 (Suppl. 1), 41-47.
12. Li, L., Schultz, R.D., 1996. Development of MDI formulations in alternative propellants with fluorinated surfactants. Respir. Drug Del. V, 360-362.
13. Matthys, H., 1990. Inhalation delivery of asthma drugs. Lung Suppl. 645-652
14. Molina, M.J., Rowland, F.S., 1974. Stratospheric sink for chlorofluoromethanes: chlorine catalysed destruction of ozone. Nature 249, 810-812.
15. Müller, B.W., Fischer, W., 1989. German patent DE3744329A1.
16. Phillips, E.M., Stella, V.J., 1993. Rapid expansion from supercritical solutions: applications to pharmaceutical processes. Int. J. Pharm. 94, 1-10.
17. Steckel, H., Thies, J., Müller, B.W., 1997. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide. Int. J. Pharm. 152, 99-110.
18. Tansey, I.J., 1995. Technological development of Airomir (salbutamole sulphate in CFC free system) MDI. Br. J. Clin. Pract. 79 (Suppl.), 13-15.
19. Tom, J.W., Debenedetti, P.G., 1991. Particle formation with supercritical fluids - a review. J. Aerosol Sci. 22 (5), 555-584.
20. Ventresca, G.P., Mackie, A.E., Moss, J.A., McDowell, J.E., Bye, A., 1994. Absorption of oral fluticasone propionate in healthy subjects. Am. J. Respir. Crit. Care Med. 149, A214.
21. Warren, S.J., Farr, S.J., 1995. Formulation of solution metered dose inhalers and comparison with aerosols emitted from conventional suspension systems. Int. J. Pharm. 124, 195-203.
22. Woodcock, A., 1997. Mdis: The Future, in: Proceedings of the International Respiratory Forum: Scientific and Clinical Relevance of Delivery Systems, London, 1997.
23. Würthwein, G., Rehder, S., Rohdewald, P., 1992. Lipophilie und Rezeptoraffinität von Glucocorticoiden. Pharm. Ztg. Wiss. 4 (4/5), 2-8.