Granzyme B: Evidence for a role in the origin of myasthenia gravis

Journal of Neuroimmunology

Volumn 201-202, Issue C, 2008, Pages 33-40

  Casciola Rosen, L ^a   Miagkov, A ^a   Nagaraju, K ^a   Askin, F ^a   Jacobson, L ^a   Rosen, A ^a   Drachman, D B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine receptor; Autoimmunity; Epsilon subunit; Granzyme B; Myasthenia gravis; Thymus

Indexed keywords

AUTOANTIGEN; CHOLINERGIC RECEPTOR; GRANZYME B;

ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DERMATOMYOSITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MYASTHENIA GRAVIS; NATURAL KILLER T CELL; NEUROMUSCULAR SYNAPSE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

AUTOIMMUNITY; CELL LINE; GENE EXPRESSION; GRANZYMES; HUMANS; METHIONINE; MYASTHENIA GRAVIS; RECEPTORS, CHOLINERGIC; RECEPTORS, NICOTINIC; SULFUR ISOTOPES; THYMUS GLAND; TRANSFECTION;

EID: 51649105095     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2008.04.041     Document Type: Article

References (43)

1. Andrade F., Roy S., Nicholson D., Thornberry N., Rosen A., and Casciola-Rosen L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 8 4 (1998) 451-460
2. Andrade F., Casciola-Rosen L.A., and Rosen A. Granzyme B-induced cell death. Acta. Haematol. 111 1-2 (2004) 28-41
3. Casciola-Rosen L., Andrade F., Ulanet D., Wong W.B., and Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J. Exp. Med. 190 6 (1999) 815-826
4. Casciola-Rosen L.A., Pluta A.F., Plotz P.H., Cox A.E., Morris S., Wigley F.M., et al. The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen. Arthritis. Rheum. 44 2 (2001) 389-396
5. Casciola-Rosen L., Nagaraju K., Plotz P., Wang K., Levine S., Gabrielson E., et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J. Exp. Med. 201 4 (2005) 591-601
6. Casciola-Rosen L., Garcia-Calvo M., Bull H.G., Becker J.W., Hines T., Thornberry N.A., et al. Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway. J. Biol. Chem. 282 7 (2007) 4545-4552
7. Castleman B. The pathology of the thymus gland in myasthenia gravis. Ann. N.Y. Acad. Sci 135 (1966) 496-503
8. Conti-Fine B.M., Diethelm-Okita B., Ostlie N., Wang W., and Milani M. Immunopathogenesis of myasthenia gravis. In: Kaminski H.J. (Ed). Myasthenia Gravis and Related Disorders (2003), Humana Press, Totowa, NJ 53-91
9. Drachman D.B. Myasthenia gravis. N. Engl. J. Med. 330 25 (1994) 1797-1810
10. Gahring L., Carlson N.G., Meyer E.L., and Rogers S.W. Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation. J. Immunol. 166 3 (2001) 1433-1438
11. Held W., MacDonald H.R., and Mueller C. Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes. Int. Immunol. 2 1 (1990) 57-62
12. Hill M., Beeson D., Moss P., Jacobson L., Bond A., Corlett L., et al. Early-onset myasthenia gravis: a recurring T-cell epitope in the adult-specific acetylcholine receptor epsilon subunit presented by the susceptibility allele HLA-DR52a. Ann. Neurol. 45 2 (1999) 224-231
13. Hoch W., McConville J., Helms S., Newsom-Davis J., Melms A., and Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat. Med. 7 3 (2001) 365-368
14. Janer M., Cowland A., Picard J., Campbell D., Pontarotti P., Newsom-Davis J., et al. A susceptibility region for myasthenia gravis extending into the HLA-class I sector telomeric to HLA-C. Hum. Immunol. 60 9 (1999) 909-917
15. Kaminski H.J., Fenstermaker R.A., Abdul-Karim F.W., Clayman J., and Ruff R.L. Acetylcholine receptor subunit gene expression in thymic tissue. Muscle. Nerve. 16 12 (1993) 1332-1337
16. Kao I., and Drachman D.B. Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis. Science 195 4273 (1977) 74-75
17. Kirchner T., Hoppe F., Schalke B., and Muller-Hermelink H.K. Microenvironment of thymic myoid cells in myasthenia gravis. Virchows. Arch. B. Cell. Pathol. Incl. Mol. Pathol. 54 5 (1988) 295-302
18. Kobayashi T., Mishina M., and Michikawa M. Alpha- beta- gamma-, delta- and epsilon-subunit specific mRNAs of acetylcholine receptors (AChRs) in cultured rat thymus myoid cells. J. Neurol. Sci. 98 (1990) 299
19. Lennon V.A., Lindstrom J.M., and Seybold M.E. Experimental autoimmune myasthenia gravis: cellular and humoral immune responses. Annals. of. the. New. York. Academy. of. Sciences. 274 (1976) 283-289
20. Le Panse R., Cizeron-Clairac G., Bismuth J., and Berrih-Aknin S. Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia. J. Immunol. 177 11 (2006) 7868-7879
21. Lindstrom J.M., Seybold M.E., Lennon V.A., Whittingham S., and Duane D.D. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology 26 11 (1976) 1054-1059
22. MacLennan C.A., Beeson D., Willcox N., Vincent A., and Newsom-Davis J. Muscle nicotinic acetylcholine receptor mRNA expression in hyperplastic and neoplastic myasthenia gravis thymus. Ann. N. Y. Acad. Sci. 841 (1998) 407-410
23. Manfredi A.A., Protti M.P., Dalton M.W., Howard Jr. J.F., and Conti-Tronconi B.M. T helper cell recognition of muscle acetylcholine receptor in myasthenia gravis. Epitopes on the gamma and delta subunits. J. Clin. Invest. 92 2 (1993) 1055-1067
24. Meraouna A., Cizeron-Clairac G., Panse R.L., Bismuth J., Truffault F., Tallaksen C., et al. The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis. Blood 108 2 (2006) 432-440
25. Nagaraju K., Cox A., Casciola-Rosen L., and Rosen A. Novel fragments of the Sjogren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death. Arthritis. Rheum. 44 10 (2001) 2376-2386
26. Navaneetham D., Penn A.S., Howard Jr. J.F., and Conti-Fine B.M. Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit. Muscle. Nerve. 24 2 (2001) 203-210
27. Niks E.H., Kuks J.B., Roep B.O., Haasnoot G.W., Verduijn W., Ballieux B.E., et al. Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5. Neurology 66 11 (2006) 1772-1774
28. Ragheb S., and Lisak R.P. Immune regulation and myasthenia gravis. Ann. N. Y. Acad. Sci. 841 (1998) 210-224
29. Rosen A., and Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell. Death. Differ. 6 1 (1999) 6-12
30. Saito R., Onodera H., Tago H., Suzuki Y., Shimizu M., Matsumura Y., et al. Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients. J. Neuroimmunol. 170 1-2 (2005) 172-178
31. Schachna L., Wigley F.M., Morris S., Gelber A.C., Rosen A., and Casciola-Rosen L. Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss. Arthritis. Rheum. 46 7 (2002) 1873-1884
32. Schluep M., Willcox N., Ritter M.A., Newsom-Davis J., Larche M., and Brown A.N. Myasthenia gravis thymus: clinical, histological and culture correlations. J. Autoimmun. 1 5 (1988) 445-467
33. Simpson J.A. Myasthenia gravis, a new hypothesis. Scott. Med. J. 5 (1960) 419
34. Skoldberg F., Ronnblom L., Thornemo M., Lindahl A., Bird P.I., Rorsman F., et al. Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus. Biochem. Biophys. Res. Commun. 291 4 (2002) 951-958
35. Sommer N., Willcox N., Harcourt G.C., and Newsom-Davis J. Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor-reactive T cells. Ann. Neurol. 28 3 (1990) 312-319
36. Suzuki Y., Onodera H., Tago H., Saito R., Ohuchi M., Shimizu M., et al. Altered expression of Th1-type chemokine receptor CXCR3 on CD4 + T cells in myasthenia gravis patients. J. Neuroimmunol. 172 1-2 (2006) 166-174
37. Vincent A., and Drachman D.B. Myasthenia gravis. Adv. Neurol. 88 (2002) 159-188
38. Vincent A., Willcox N., Hill M., Curnow J., MacLennan C., and Beeson D. Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravis. Immunol. Rev. 164 (1998) 157-168
39. Wakkach A., Guyon T., Bruand C., Tzartos S., Cohen-Kaminsky S., and Berrih-Aknin S. Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis. J. Immunol. 157 8 (1996) 3752-3760
40. Wang Z.Y., Okita D.K., Howard Jr. J.F., and Conti-Fine B.M. CD4 + T cell repertoire on the epsilon subunit of muscle acetylcholine receptor in myasthenia gravis. J. Neuroimmunol. 91 1-2 (1998) 33-42
41. Wekerle H., Ketelsen U.P., Zurn A.D., and Fulpius B.W. Intrathymic pathogenesis of myasthenia gravis: transient expression of acetylcholine receptors on thymus-derived myogenic cells. Eur. J. Immunol. 8 8 (1978) 579-582
42. Wekerle H., Hohlfeld R., Ketelsen U.P., Kalden J.R., and Kalies I. Thymic myogenesis, T-lymphocytes and the pathogenesis of myasthenia gravis. Ann. N. Y. Acad. Sci. 377 (1981) 455-476
43. Zhou L., McConville J., Chaudhry V., Adams R.N., Skolasky R.L., Vincent A., et al. Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients. Muscle. Nerve. 30 1 (2004) 55-60