The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage: Neurological consequences of highly pathogenic Fujian H5N1 strains

Journal of Molecular Neuroscience

Volumn 35, Issue 3, 2008, Pages 339-343

  Pasquato, Antonella ^a   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Fujian; Furin; Hemagglutinin HA; Heparin; Influenza virus; Neurological diseases

Indexed keywords

FURIN; HEMAGGLUTININ;

ACIDITY; ARTICLE; FUJIAN LIKE STRAIN; GENE MUTATION; GENE SEQUENCE; IMMUNE RESPONSE; IMMUNITY; INFLUENZA VIRUS A H5N1; NONHUMAN; PH; PROTEIN DEGRADATION; VACCINATION; VIRUS STRAIN;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BIRDS; EVOLUTION, MOLECULAR; FURIN; HEMAGGLUTININS, VIRAL; HEPARIN; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA VACCINES; INFLUENZA, HUMAN; MUTATION; PEPTIDES; VACCINATION; VARIATION (GENETICS); VIRULENCE;

AVES; ORTHOMYXOVIRIDAE;

EID: 51649093830     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-008-9052-z     Document Type: Article

References (19)

1. A. Basak M. Zhong J. S. Munzer M. Chretien N. G. Seidah 2001 Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides Biochemical Journal 353 537 545
2. E. C. Claas A. D. Osterhaus R. van Beek 1998 Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus Lancet 351 472 477
3. E. Decroly S. Wouters C. Di Bello C. Lazure J. M. Ruysschaert N. G. Seidah 1996 Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines Journal of Biological Chemistry 271 30442 30450
4. M. Garcia J. M. Crawford J. W. Latimer E. Rivera-Cruz M. L. Perdue 1996 Heterogeneity in the haemagglutinin gene and emergence of the highly pathogenic phenotype among recent H5N2 avian influenza viruses from Mexico Journal of General Virology 77 Pt 7 1493 1504
5. W. Garten H. D. Klenk 1999 Understanding influenza virus pathogenicity Trends in Microbiology 7 99 100
6. E. A. Govorkova J. E. Rehg S. Krauss 2005 Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004 Journal of Virology 79 2191 2198
7. D. B. Lewis 2006 Avian flu to human influenza Annual Review of Medicine 57 139 154
8. S. M. Maricich J. L. Neul T. E. Lotze 2004 Neurologic complications associated with influenza A in children during the 2003-2004 influenza season in Houston, Texas Pediatrics 114 e626 e633
9. C. H. Park M. Ishinaka A. Takada 2002 The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice Archives of Virology 147 1425 1436
10. A. Pasquato M. Dettin R. Gambaretto L. Tonin N. G. Seidah C. Di Bello 2007 Heparin optimizes the furin cleavage of HIV-1 gp160 peptides FEBS Lett., 581 5807 5813
11. T. Rowe D. S. Cho R. A. Bright L. A. Zitzow J. M. Katz 2003 Neurological manifestations of avian influenza viruses in mammals Avian Diseases 47 1122 1126
12. N. G. Seidah M. Chretien 1999 Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides Brain Research 848 45 62
13. N. G. Seidah M. Chretien R. Day 1994 The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions Biochimie 76 197 209
14. F. D. Silvano M. Yoshikawa A. Shimada K. Otsuki T. Umemura 1997 Enhanced neuropathogenicity of avian influenza A virus by passages through air sac and brain of chicks Journal of Veterinary Medical Science 59 143 148
15. G. J. Smith X. H. Fan J. Wang 2006 Emergence and predominance of an H5N1 influenza variant in China Proceedings of the National Academy of Sciences of the United States of America 103 16936 16941
16. E. Starick O. Werner 2003 Detection of H7 avian influenza virus directly from poultry specimens Avian Diseases 47 1187 1189
17. A. Stieneke-Grober M. Vey H. Angliker 1992 Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease EMBO Journal 11 2407 2414
18. G. Thomas 2002 Furin at the cutting edge: from protein traffic to embryogenesis and disease Nature Reviews. Molecular Cell Biology 3 753 766
19. T. Togashi Y. Matsuzono M. Narita T. Morishima 2004 Influenza-associated acute encephalopathy in Japanese children in 1994-2002 Virus Research 103 75 78