Excessive daytime sleepiness in sleep apnea: It is not just apnea hypopnea index

Sleep Medicine

Volumn 9, Issue 7, 2008, Pages 712-714

  Vgontzas, Alexandros N ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCADIAN RHYTHM SLEEP DISORDER; COHORT ANALYSIS; COMORBIDITY; DAYTIME SOMNOLENCE; DISEASE SEVERITY; EDITORIAL; FATIGUE; HUMAN; METABOLIC DISORDER; NIGHT SLEEP; NONHUMAN; OBESITY; POSITIVE END EXPIRATORY PRESSURE; PREVALENCE; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; SLEEP TIME;

CIRCADIAN RHYTHM; COMORBIDITY; DISORDERS OF EXCESSIVE SOMNOLENCE; HUMANS; OBESITY; RISK FACTORS; SLEEP APNEA SYNDROMES; SLEEP APNEA, OBSTRUCTIVE; SLEEP STAGES;

EID: 51549117663     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2008.05.001     Document Type: Editorial

References (25)

1. Bixler E.O., Kales A., Soldatos C.R., Kales J.D., and Healey S. Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatr 136 (1979) 1257-1262
2. Ohayon M.M., Caulet M., Philip P., Guilleminault C., and Priest R.G. How sleep and mental disorders are related to complaints of daytime sleepiness. Arch Intern Med 157 (1997) 2645-2652
3. Breslau N., Roth T., Rosenthal L., and Andreski P. Daytime sleepiness: an epidemiological study of young adults. Am J Public Health 87 (1997) 1649-1653
4. Bixler E.O., Vgontzas A.N., Lin H.M., Calhoun S.L., Vela-Bueno A., and Kales A. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab 90 (2005) 4510-4515
5. Roure N., Gomez S., Mediano O., Duran J., de la Peña M., Capote F., et al. Daytime sleepiness and polysomnography in obstructive sleep apnea patients. Sleep Med 9 (2008) 727-731
6. Vgontzas A.N., Bixler E.O., Tan T.L., Kantner D., Martin L.F., and Kales A. Obesity without sleep apnea is associated with daytime sleepiness. Arch Intern Med 158 (1998) 1333-1337
7. Vgontzas A.N., Tan T.L., Bixler E.O., Martin L.F., Shubert D., and Kales A. Sleep apnea and sleep disruption in obese patients. Arch Intern Med 154 (1994) 1705-1711
8. Punjabi N.M., O'hearn D.J., Neubauer D.N., Nieto F.J., Schwartz A.R., Smith P.L., et al. Modeling hypersomnolence in sleep-disordered breathing. A novel approach using survival analysis. Am J Respir Crit Care Med 159 (1999) 1703-1709
9. Resta O., Foschino Barbaro M.P., Bonfitto P., Giliberti T., Depalo A., Pannacciulli N., et al. Low sleep quality and daytime sleepiness in obese patients without obstructive sleep apnoea syndrome. J Intern Med 253 (2003) 536-543
10. Young T., Palta M., Dempsey J., Skatrud J., Weber S., and Badr S. The occurrence of sleep-disordered breathing among middled-age adults. N Engl J Med 328 (1993) 1230-1235
11. Bixler E.O., Vgontzas A.N., Ten Have T., Tyson K., and Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 157 (1998) 144-148
12. Bixler E.O., Vgontzas A.N., Lin H.M., Ten Have T., Rein J., Vela-Bueno A., et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med 163 (2001) 608-613
13. Kapur V.K., Baldwin C.M., Resnick H.E., Gottlieb D.J., and Nieto F.J. Sleepiness in patients with moderate to severe sleep-disordered breathing. Sleep 28 (2005) 472-477
14. Chugh D.K., and Dinges D.F. Mechanisms of sleepiness in obstructive sleep apnea. In: Pack A.I. (Ed). Sleep apnea: pathogenesis, diagnosis, and treatment (2002), Marcel Dekker, New York 265-286
15. Pack A.I., Black J.E., Schwartz J.R., and Matheson J.K. Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea. Am J Respir Crit Care Med 164 (2001) 1675-1681
16. Resnick H.E., Carter E.A., Aloia M., and Phillips B. Cross-sectional relationship of reported fatigue to obesity, diet, and physical activity: results from the third national health and nutrition examination survey. J Clin Sleep Med 2 (2006) 163-169
17. Theorell-Haglöw J., Lindberg E., and Janson C. What are the important risk factors for daytime sleepiness and fatigue in women?. Sleep 29 (2006) 751-757
18. Resta O., Foschino-Barbaro M.P., Legari G., Talamo S., Bonfitto P., Palumbo A., et al. Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects. Int J Obes Relat Metab Disord 25 (2001) 669-675
19. Vgontzas A.N., Legro R.S., Bixler E.O., Grayev A., Kales A., and Chrousos G.P. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab 86 (2001) 517-520
20. Basta M., Lin H.M., Pejovic S., Sarrigiannidis A., Bixler E., and Vgontzas A.N. Lack of regular exercise, depression, and degree of apnea are predictors of excessive daytime sleepiness in patients with sleep apnea: sex differences. J Clin Sleep Med 4 (2008) 19-25
21. Guan Z., Vgontzas A.N., Bixler E.O., and Fang J. Sleep is increased by weight gain and decreased by weight loss in mice. Sleep 5 (2008) 627-633
22. Vgontzas A.N., Bixler E.O., and Chrousos G.P. Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann NY Acad Sci 1083 (2006) 329-344
23. Leproult R., Colecchia E.F., Berardi A.M., Stickgold R., Kosslyn S.M., and Van Cauter E. Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated. Am J Physiol Regul Integr Comp Physiol 284 (2003) R280-R290
24. Van Dongen H.P.A., Baynard M.D., Maislin G., and Dinges D.F. Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. Sleep 27 (2004) 423-433
25. Gottlieb D.J., O'Conno G.T., and Wilk J.B. Genome-wide association of sleep and circadian phenotypes. BMC Med Genet 8 (2007) S1-S9