Immunorestoration and augmentation of mitogen lymphocyte response in Graffi tumor bearing hamsters by purified saponin mixture from Astragalus corniculatus

Phytomedicine

Volumn 15, Issue 10, 2008, Pages 876-881

  Toshkova, R A ^a   Krasteva, I N ^b   Nikolov, S D ^b  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Astragalus corniculatus; Graffi myeloid tumor; LPS; Mitogen response; PHA; Saponins; Spleen lymphocytes

Indexed keywords

19ALPHA HYDROXYOLEAN 12 ENE 28,21BETA OLIDE 3BETA DEXTRO XYLOPYRANOSIDE; 21ALPHA HYDROXYOLEAN 12 EN 28 OIC ACID 3BETA 4 OXOPENTOPYRANOSIDE; 3BETA O [O 4 OXOPENTOPYRANOSYL(1-2) BETA DEXTRO GLUCOPYRANOSYL] 21ALPHA HYDROXYOLEAN 12 EN 28 OIC ACID; ASTRAGALUS EXTRACT; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTRAGALUS CORNICULATUS; B LYMPHOCYTE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DRUG STRUCTURE; FEMALE; HAMSTER; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE;

ANIMALS; ASTRAGALUS PLANT; CELL PROLIFERATION; CRICETINAE; LYMPHOCYTES; MITOGENS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; SAPONINS;

ASTRAGALUS CORNICULATUS; CRICETINAE; FABACEAE;

EID: 51549090660     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2007.11.026     Document Type: Article

References (27)

1. Block K.I., Mark N., and Mead M.S. Immune system effects of Echinacea, Ginseng and Astragalus: a review. Integr. Cancer Ther. 2 (2003) 247-267
2. Cheng X.D., Hou C.H., Zhang X.J., Xie H.J., Zhou W.Y., Wang L., Zhang S.B., and Qian R.L. Effects of Huangqi (Hex) on inducing cell differentiation and cell death in K562 and HEL cells. Acta Biochim. Biophys. Sin. (Shanghai) 36 (2004) 211-217
3. Chu D., Lin J., and Wong W. The in vitro potentiation of LAK cell cytotoxicity in cancer and AIDS patients induced by F3-A fractionated extract of Astragalus membranaceus. Chin. J. Oncol. 16 (1994) 167-171
4. Dong J.C., and Dong X.H. Comparative study on effect of Astragalus injection and interleukin-2 in enhancing anti-tumor metastasis action of dendrite cells. Zhongguo Zhong Xi Yi Jie He Za Zhi 25 (2005) 236-239
5. Hong W., and Sporn M.B. Recent advances in chemoprevention of cancer. Science (Washington, DC) 278 (1997) 1073-1077
6. Kajimura K., Takagi Y., Nakano M., and Mimura M. Effects of Astragali radix from various original plants on peritoneal exudate cell function in mice. Nat. Med. 51 (1997) 361-364
7. Kemper, K., Small, R., 1999. Astragalus (Astragalus membranaceus). Longwood Herbal Task Force. Available from: http://www.longwoodherbal.org/astragalus/astragalus.pdf.
8. Krasteva, I., 2006. Phytochemical investigation of Astragalus corniculatus Bieb. (Fabaceae). Ph.D. Thesis, Faculty of Pharmacy, Medical University, Bulgaria.
9. Krasteva I., Toshkova R., and Nikolov S. Protective effect of Astragalus corniculatus saponins against myeloid Graffi tumor in hamsters. Phytother. Res. 18 (2004) 255-257
10. Krasteva I., Nikolov S., Kaloga M., and Mayer G. Triterpenoid saponins from Astragalus corniculatus. Z. Naturforsh. 61B (2006) 1166-1169
11. Lacaille-Dubois M.A. Saponins as immunostimulants and immunoadjuvants. In: Wagner H. (Ed). Immunomodulatory Agents from Plants (1999), Birkhäuser Verlag AG, Basel, Boston, Berlin 243-272
12. Lacaille-Dubois M.A. Bioactive saponins with cancer related and immunomodulatory activity. In: Atta-Ur-Rahman (Ed). Studies in Natural Products Chemistry (2005), Elsevier, Amsterdam, The Netherlands 209-246
13. Lau B., Ruckle H., Botolazzo T., and Lui P. Chinese medicinal herbs inhibit growth of murine renal cell carcinoma. Cancer Biother. 9 (1994) 153-161
14. Marinova S., Stoychkov J., Benbassat N., Nikolov S., and Sarneva M. Immunomodulating effect of triterpenoid saponins from Astragalus onobrychis L. Farmacia (Sofia) 6 (1994) 38-41
15. Masson P.R., and Gwanzura L. Reduced lymphocyte responses to mitogens in natural and experimental trichomoniasis. Infect. Immunol. 58 (1990) 3553-3557
16. Pistelli L. Secondary metabolites of genus Astragalus: structure and biological activity. In: Atta-Ur-Rahman (Ed). Studies in Natural Products Chemistry (Bioactive Natural Products, Part H) (2002), Elsevier, Amsterdam, The Netherlands 443-545
17. Rios J., and Waterman P. A review of the pharmacology and toxicology of Astragalus. Phytother. Res. 14 (1997) 411-418
18. Sinclair S. Chinese herbs: a clinical review of Astragalus, Ligusticum and Schizandrae. Altern. Med. Rev. 3 (1998) 338-344
19. Sun Y. Chinese medicinal herbs as biologic response modifiers. In: Lotzova E., and Herberman R. (Eds). Natural Immunity, Cancer and Biologic Response Modification (1986), Basel, Karger 206-211
20. Tan B.K., and Vanitha J. Immunomodulatory and antimicrobial effects of some traditional Chinese medicinal herbs: a review. Curr. Med. Chem. 11 (2004) 1423-1430
21. Toshkova, R., 1995. Immunity and experiments for immunomodulation in hamsters with experimental tumor, primary induced by virus of Graffi. Ph.D. Thesis, Institute of Experimental Pathology and Parasitology, BAS, Bulgaria.
22. Toshkova R., Krasteva I., Wesselinova D., and Nikolov S. Influence of purified saponin mixture from Astragalus corniculatus Bieb. on phagocyte cells in Graffi tumor-bearing hamsters. J. Ethnopharmacol. 109 (2007) 394-399
23. Verotta L., Guerini M., El-Sebakhy N.A., Asaad A.M., Toaima S.M., Abou-Sheer M.E., Luo Y.D., and Pezzuto J.M. Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitotherapia 72 (2001) 894-905
24. Verotta L., Guerini M., El-Sebakhy N.A., Asaad A.M., Toaima S.M., Radwan M.M., Luo Y.D., and Pezzuto J.M. Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation. Planta Med. 68 (2002) 986-994
25. Yang Z.S., Sun H.X., and Fang W.H. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune response to ovalbumin in mice. Vaccine 23 (2005) 196-203
26. Yesilada E., Bedir E., Calis I., Takaishi Y., and Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J. Ethnopharmacol. 96 (2005) 71-77
27. Yoshida Y., Wang Q., Liu J., Shan B., and Yamashita U. Immunomodulating activity of Chinese medicinal herbs and Oleandrina diffusa in particular. Int. J. Immunopharmacol. 19 (1997) 359-370