Identification of critical amino acid residues for human iNOS functional activity

Protein Journal

Volumn 27, Issue 5, 2008, Pages 309-318

  Naureckiene, Saule ^a,b   Kodangattil, Sreekumar R ^a   Kaftan, Edward J ^a   Jones, Philip G ^a,c   Kennedy, Jeffrey D ^a   Rogers, Kathryn E ^a,d   Chanda, Pranab K ^a  

^a PFIZER INC   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d EnVivo Pharmaceuticals   (United States)

Author keywords

E. coli expression; Lac tac tac promoter; Nitric oxide reductase; Nitric oxide synthase; Point mutation

Indexed keywords

AMINO ACID; INDUCIBLE NITRIC OXIDE SYNTHASE;

ARTICLE; ESCHERICHIA COLI; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MUTATION; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CELL-FREE SYSTEM; ESCHERICHIA COLI; GENE EXPRESSION; GENETIC VECTORS; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NITRIC OXIDE SYNTHASE TYPE II; PLASMIDS; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI;

EID: 51449120029     PISSN: 15723887     EISSN: 15734943     Source Type: Journal    
DOI: 10.1007/s10930-008-9139-y     Document Type: Article

References (27)

1. Abu-Soud HM, Stuehr DJ (1993) Proc Natl Acad Sci USA 90:10769-10772
2. Alderton WK, Cooper CE, Knowles RG (2001) Biochem J 357:593
3. Bradford MM (1976) Anal Biochem 72:248
4. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (1983) J Comp Chem 4:187
5. Castrillo A, Diaz-Guerra MJ, Hortelano S, Martin-Sanz P, Bosca L (2000) Mol Cell Biol 20:1692
6. Charles IG, Palmer RM, Hickery MS, Bayliss MT, Chubb AP, Hall VS, Moss DW, Moncada S (1993) Proc Natl Acad Sci USA 90:11419
7. Cho HJ, Xie QW, Calaycay WJ, Mumford RA, Swiderek KM, Lee LD, Nathan C (1992) J Exp Med 176:599
8. Strausberg RL, Feingold EA, Grouse LH, Derge DG, Klausner RD et al (2002) Proc Natl Acad Sci USA 99:16899
9. Fosseta JD, Niu XD, Lunn CA, Zavodny PJ, Narula S (1996) FEBS Lett 379:135
10. Garber NC, Nishida CR (1997) Arch Biochem Biophys 343:249
11. Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED (2004) J Biol Chem 27:37918
12. Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (1993) Proc Natl Acad Sci USA 90:3491
13. Griffith OW, Stuehr DJ (1995) Annu Rev Physiol 57:707
14. Jao SC, Huang LF, Hwang SM, Li WS (2006) Biochemistry 45:1547
15. Kroncke DJ, Feshel K, Kolb-Bachofen V (1995) Biol Chem Hoppe-Seyler 376:327
16. Levy D, Hoke A, Zochodne DW (1999) Neurosci Lett 260:207
17. Livingston RJ, Rieder MJ, Shaffer T, Bertucci C, Baier CN et al (2005) GenBank accession AAY43131
18. Marletta MA (1999) J Biol Chem 268:12231
19. Nathan CF, Xie QW (1994) J Biol Chem 269:13725
20. Palmer RM (1988) Nature 333:664
21. Radisky ES, Lu C-JK, Kwan G, Koshland DE Jr (2005) Biochemistry 44:6823
22. Sali A, Blundell T (1993) J Mol Biol 234:779
23. Sali A, Potterton L, Yuan F, van Vlijmen H, Karplus M (1995) Proteins 23:318
24. Sherman PA, Laubach VE, Reep BR, Wood ER (1993) Biochemistry 32:11600
25. Sung CS, Wen ZH, Chang WK, Ho ST, Tsai SK, Chang YC, Wong CH (2004) Brain Res 1015:145
26. Vallance P, Leiper J (2002) Nat Rev Drug Discov 1:939
27. Zimmerman SA, Ferry JG (2006) Biochemistry 45:5149