Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8685-8696

  Shrestha, Ajaya R ^a   Shindo, Takashi ^a   Ashida, Noriyuki ^b   Nagamatsu, Tomohisa ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b YAMASA CORPORATION   (Japan)

Author keywords

5 Deazaflavin; Cholestane; Hybrid compound; LigandFit; Protein tyrosine kinase

Indexed keywords

2 HYDROXYMETHYLENECHOLEST 4 EN 3 ONE; 5 DEAZAFLAVIN; 8' ETHYL 3' METHYL 5' DEAZACHOLEST 2,4 DIENO[2,3 G]PTERIDINE 2',4'(3'H,8'H) DIONE; CHOLESTANE DERIVATIVE; DIPHENYL ETHER; PROTEIN TYROSINE KINASE; PTERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; STEROID; TOLUENESULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYBRID; IN VITRO STUDY; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; BINDING SITES; CELL LINE, TUMOR; CHOLESTANES; DRUG DESIGN; FLAVINS; HUMANS; INHIBITORY CONCENTRATION 50; KB CELLS; LEUKEMIA, LYMPHOID; LIGANDS; MODELS, MOLECULAR; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51449118185     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.089     Document Type: Article

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