A Randomized Controlled Trial of Theophylline Versus CO2 Inhalation for Treating Apnea of Prematurity

Journal of Pediatrics

Volumn 153, Issue 4, 2008, Pages 513-518

  Al Saif, Saif ^a   Alvaro, Ruben ^a   Manfreda, Juri ^a   Kwiatkowski, Kim ^a   Cates, Don ^a   Qurashi, Mansour ^a   Rigatto, Henrique ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; THEOPHYLLINE;

ARTICLE; BRAIN BLOOD FLOW; BREATHING DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; FEMALE; HEART ARRHYTHMIA; HUMAN; INFANT; INTERMETHOD COMPARISON; MALE; NEWBORN APNEA; PRIORITY JOURNAL; RESTLESSNESS; THERAPY EFFECT;

ADMINISTRATION, INHALATION; APNEA; BRONCHODILATOR AGENTS; CARBON DIOXIDE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; PILOT PROJECTS; THEOPHYLLINE; TREATMENT OUTCOME;

EID: 51449103572     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2008.04.025     Document Type: Article

References (39)

1. Poets C.F., and Sens B. Changes in intubation rates and outcome of very low birth weight infants: a population-based study. Pediatrics 98 (1996) 24-27
2. Rigatto H. Periodic breathing. In: Loughlin G.M., Carroll J.L., and Marcus C.L. (Eds). Sleep and Breathing in Children: A Developmental Approach (2000), Marcel Dekker, New York 237-272
3. Henderson-Smart D.J., and Steer P. Methylxanthine treatment for apnea in preterm infants. Cochrane Database Syst Rev 4 (1998)
4. Henderson-Smart D.J., and Steer P. Prophylactic caffeine to prevent postoperative apnea following general anesthesia in preterm infants. Cochrane Database Syst Rev 4 (2001) CD000048
5. 2 receptor. Nature 388 (1997) 674-678
6. Shannon D.C., Gotay F., Stein I.M., Rogers M.C., Todres I.D., and Moylan F.M.B. Prevention of apnea and bradycardia in low birth weight infants. Pediatrics 55 (1975) 589-594
7. Uauy R., Shapir D.L., Smith B., and Warshaw J.B. Treatment of severe apnea in prematures with orally administered theophylline. Pediatrics 55 (1975) 595-598
8. Grosfeld J.L., Dalsing M.C., Hull M., and Weber T.R. Neonatal apnea, xanthines, and necrotizing enterocolitis. J Pediatr Surg 18 (1983) 80-84
9. Kitchen W.H., Doyle L.W., Ford G.W., Richards A.L., Lissenden J.V., and Ryan M.M. Cerebral palsy in very low birth weight infants surviving to 2 years with modern perinatal intensive care. Am J Perinatol 4 (1987) 29-35
10. Lagercrantz H. Improved understanding of respiratory control: implications for the treatment of apnoea. Eur J Pediatr 154 (1995) S10-S12
11. Thruston J.L., Hauhart R.E., and Dirgo J.A. Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice. Science 201 (1978) 649-651
12. Schmidt B., Roberts R.S., Davis P., Doyle L.W., Barrington K.J., Ohlsson A., et al., Caffeine for Apnea of Prematurity Trial Group. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 357 (2007) 1893-1902
13. Schmidt B., Roberts R.S., Davis P., Doyle L.W., Barrington K.J., Ohlsson A., et al., Caffeine for Apnea of Prematurity Trial Group. Caffeine therapy for apnea of prematurity. N Engl J Med 354 (2006) 2112-2121
14. Bucher H.U., and Duc G. Does caffeine prevent hypoxemic episodes in premature infants?. Eur J Pediatr 147 (1998) 288-291
15. Cherniack N.S., and Longobardo G.S. Abnormalities in respiratory rhythm. In: Fishman A.P., Cherniack N.S., Widdicombe J.G., and Geiger S.R. (Eds). Handbook of Physiology: The Respiratory System II (1986), American Physiological Society, Bethesda, MD 729-749
16. Dempsey J.A., and Skatrud J.B. A sleep-induced apneic threshold and its consequences. Am Rev Respir Dis 133 (1986) 1163-1170
17. Skatrud J.B., and Dempsey J.A. Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation. J Appl Physiol 55 (1983) 813-822
18. 2 and added dead space on idiopathic central sleep apnea. J Appl Physiol 82 (1997) 981-26
19. Xie A., Rutherford R., Rankin F., Wong B., and Bradley T.D. Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea. Am J Respir Crit Care Med 152 (1995) 1950-1955
20. Younes M. The physiologic basis of central apnea and periodic breathing. Curr Pulmonol 10 (1989) 265-365
21. 2 on ventilation and diaphragmatic electromyography in newborn infants. Respir Physiol 62 (1985) 387-397
22. 2 as a potential treatment for apnea of prematurity. Semin Perinatol 25 (2001) 100-106
23. Rigatto H., and Brady J.P. Periodic breathing and apnea in preterm infants, I: evidence for hypoventilation possibly due to central respiratory depression. Pediatrics 50 (1972) 202-218
24. 2 in preterm infants. J Appl Physiol 39 (1975) 896-899
25. 2 in preterm infants. Am Rev Respir Dis 143 (1991) 101-104
26. Dreyfus-Brisac C. Ontogenesis of brain bioelectrical activity and sleep organization in neonates and infants. In: Falkner F., and Tanner J.M. (Eds). Human Growth Vol 3 (1979), Plenum, London 157
27. Dreyfus-Brisac C. Ontogenesis of sleep in human prematures after 32 weeks of conceptional age. Dev Psychobiol 3 (1970) 91-121
28. 2 breathing measured transcutaneously in humans by a bidirectional pulsed, ultrasound Doppler blood velocity meter. Acta Physiol Scand 110 (1980) 167-173
29. Purves M.J. Control of cerebral blood vessels: present state of the art. Ann Neurol 3 (1978) 377-383
30. Howell J., Clozel M., and Aranda J.V. Adverse effects of caffeine and theophylline in the newborn infant. Semin Perinatol 5 (1981) 359-369
31. Fredholm B.B. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol 76 (1995) 93-101
32. Hendeles L., and Weinberger M. Theophylline: a state-of-the-art review. Pharmacotherapy 3 (1983) 2-44
33. Moore E.S., Faix R.G., Banagale R.C., and Grasela T.H. The population pharmacokinetics of theophylline in neonates and young infants. J Pharmacokinet Biopharmam 17 (1989) 47-66
34. Hoecker C., Nelle M., Poeschl J., Beedgen B., and Linderkamp O. Caffeine impairs cerebral and intestinal blood flow velocity in preterm infants. Pediatrics 109 (2002) 784-787
35. Herlenius E., Lagercrantz H., and Yamamoto Y. Adenosine modulates inspiratory neurons and the respiratory pattern in the brainstem of neonatal rats. Pediatr Res 42 (1997) 46-53
36. Dux E., Fastborn J., Ungerstgeadt U., Rudolphi K., and Fredholm B.B. Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus. Brain Res 516 (1990) 248-256
37. 2 on "inspiratory drive" and "effective" timing in preterm infants. Early Hum Dev 5 (1981) 63-70
38. Chang J., and Gray P.H. Aminophylline therapy and cerebral blood flow velocity in preterm infants. J Paediatr Child Health 30 (1994) 123-125
39. McDonnell M., Ives N.K., and Hope P.L. Intravenous aminophylline and cerebral blood flow in preterm infants. Arch Dis Child 67 (1992) 416-418