Methods in safety pharmacology in focus

Journal of Pharmacological and Toxicological Methods

Volumn 58, Issue 2, 2008, Pages 69-71

  Pugsley, Michael K ^a   Gallacher, David J ^b   Towart, Rob ^b   Authier, Simon ^c   Curtis, Michael J ^d  

^a JOHNSON AND JOHNSON   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c LAB Research Inc   (Canada)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; ESMOLOL; MONOCLONAL ANTIBODY; REMIFENTANIL;

CARDIOVASCULAR FUNCTION; COGNITION; CONTRACT RESEARCH ORGANIZATION TEST; DETRENDED FLUCTUATION ANALYSIS; DIAGNOSTIC VALUE; DOG; DRUG SAFETY; EDITORIAL; HEART BEAT; LEGAL ASPECT; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MULTIFRACTAL DETRENDED FLUCTUATION ANALYSIS; NONHUMAN; QT PROLONGATION; RAT; SCREENING TEST; UNITED KINGDOM; VALIDATION PROCESS; ZEBRA FISH;

ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; HUMANS; PHARMACEUTICAL PREPARATIONS; RATS; TOXICITY TESTS;

DANIO RERIO; PRIMATES; RATTUS;

EID: 51449101001     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2008.07.002     Document Type: Editorial

References (15)

1. Authier S., Tanguay F., Fournier S., Gauvin D.V., Legaspi M., Chaurand F., Breault C., and Troncy E. Conscious and anesthetized non-human primate safety pharmacology models: Cardiovascular sensitivity comparison. Journal of Pharmacological & Toxicological Methods 58 (2008) 69-71 10.1016/j.vascn.2008.05.004 (this issue)
2. Gauvin D.V., and Baird T.J. A functional observational battery in non-human primates for regulatory required neurobehavioral assessments. Journal of Pharmacological & Toxicological Methods 58 (2008) 91-96 10.1016/j.vascn.2008.05.002 (this issue)
3. Himmel H. Safety pharmacology assessment of CNS function in juvenile and adult rats: effects of pharmacological reference compounds. Journal of Pharmacological & Toxicological Methods 58 (2008) 135-152 10.1016/j.vascn.2008.06.001 (this issue)
4. Langheinrich U., Vacun G., and Wagner T. Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Journal of Applied Pharmacology 193 (2003) 370-382
5. Li D., Chiang A.Y., Clawson C.A., Main B.W., and Leishman D.J. Heartbeat dynamics in adrenergic-blocker treated conscious Beagle dogs. Journal of Pharmacological & Toxicological Methods 58 (2008) 123-133 10.1016/j.vascn.2008.05.005 (this issue)
6. Lindgren S., Bass A.S., Briscoe R., Bruse K., Friedrichs G.S., Kallman M.-J., Markgraf C., Patmore L., and Pugsley M.K. Benchmarking safety pharmacology regulatory packages and best practice. Journal of Pharmacological & Toxicological Methods 58 (2008) 103-113 10.1016/j.vascn.2008.07.001 (this issue)
7. Mayden R.L., Tang K.L., Conway K.W., Freyhof J., Chamberlain S., Haskins M., Schneider L., Sudkamp M., Wood R.M., Agnew M., Bufalino A., Sulaiman Z., Miya M., Saitoh K., and He S. Phylogenetic relationships of Danio within the order Cypriniformes: A framework for comparative and evolutionary studies of a model species. Journal of Experimental Zoology 308B (2007) 642-654
8. Milan D.J., Peterson T.J., Ruskin N.J., Peterson R.T., and MacRae C.A. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation 107 (2003) 1355-1358
9. Milan D.J., Jones I.L., Ellinor P.T., and MacRae C.A. In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation. American Journal of Physiology 291 (2006) H269-H273
10. Mittelstadt S.W., Hemenway C.L., Craig M.P., and Hove J.R. Evaluation of zebrafish embryos as a model for assessing inhibition of hERG. Journal of Pharmacological & Toxicological Methods 57 (2008) 100-105
11. Redfern W., Waldron G., Winter M.J., Butler P., Holbrook M., Wallis R., and Valentin J.P. Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?. Journal of Pharmacological & Toxicological Methods 58 (2008) 115-122 10.1016/j.vascn.2008.05.006 (this issue)
12. Valentin J.P., and Hammond T. Safety and secondary pharmacology: Successes, threats, challenges and opportunities. Journal of Pharmacological & Toxicological Methods 58 (2008) 79-89 10.1016/j.vascn.2008.05.002 (this issue)
13. + channels: friend and foe. Trends in Pharmacological Sciences 22 (2001) 260-266
14. Vargas H.M., Bass A.S., Breidenbach A., Feldman H.S., Gintant G.A., Harmer A., Heath B., Hoffmann P.K., Lagrutta A., Leishmann D., McMahon N., Mittelstadt S., Polonchuk L., Pugsley M.K., Salata J.J., and Valentin J.-P. hERG potassium channel testing for biologicals: Scientific review and recommendations on preclinical cardiovascular safety evaluation. Journal of Pharmacological & Toxicological Methods 58 (2008) 73-77 10.1016/j.vascn.2008.04.001 (this issue)
15. Wang H., Long A., Marty S.D., Sassa S., and Lin S. A zebrafish model for hepatoerythropoietic porphyria. Nature Genetics 20 3 (1998) 222-223