An unreported mutation within protein Z gene is associated with very low protein levels in women with fetal loss

Fertility and Sterility

Volumn 90, Issue 3, 2008, Pages 864-865

  Grandone, Elvira ^a   Colaizzo, Donatella ^a   Cappucci, Filomena ^a   D'Ambrosio, Rosa Lucia ^a   Vecchione, Gennaro ^a   Margaglione, Maurizio ^a,b  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID BINDING PROTEIN;

ARTICLE; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS WASTAGE; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ABORTION, SPONTANEOUS; ADULT; BLOOD PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION;

EID: 51449085317     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.07.1318     Document Type: Article

References (8)

1. Broze Jr. G.J. Protein Z dependent regulation of coagulation. Thromb Haemost 86 (2001) 8-13
2. Kemkes-Matthes B., and Matthes K.J. Protein Z deficiency: a new cause of bleeding tendency. Thromb Res 79 (1995) 49-55
3. Yin Z.F., Huang Z.F., Cui J., Fiehler R., Lasky N., Ginsburg D., et al. Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A 97 (2000) 6734-6738
4. Kemkes-Matthes B., Nees M., Kuhnel G., Matzdorff A., and Matthes K.J. Protein Z influences prothrombotic phenotype of factor V Leiden in humans. Thromb Res 106 (2002) 183-185
5. Gris J.C., Quéré I., Dechaud H., Mercier E., Pincon C., Hoffet M., et al. High frequency of protein Z deficiency in patients with unexplained early fetal loss. Blood 99 (2002) 2606-2608
6. Bretelle F., Arnoux D., Shojai R., D'Ercole C., Sampol J., Dignat F., et al. Protein Z in patients with pregnancy complications. Am J Obstet Gynecol 193 (2005) 1698-1702
7. Grandone E., Colaizzo D., Cappucci F., Cocomazzi N., and Margaglione M. Protein Z levels and unexplained fetal losses. Fertil Steril 82 (2004) 982-983
8. Santacroce R., Sarno M., Cappucci F., Sessa F., Colaizzo D., Brancaccio V., et al. Low protein Z levels and risk of occurrence of deep vein thrombosis. J Thromb Haemost 4 (2006) 2417-2422