IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice

Neurobiology of Disease

Volumn 17, Issue 2, 2004, Pages 171-178

  Chen, Zhiguo ^a   Duan, Rui Sheng ^a   Concha, Q Hernan ^a   Wu, Qinyang ^a,b   Mix, Eilhard ^c   Winblad, Bengt ^a   Ljunggren, Hans Gustaf ^a   Zhu, Jie ^a,b,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d JILIN UNIVERSITY   (China)

Author keywords

Hippocampus; IL 12p35 deficiency; Kainic acid; Microglia; Neurodegeneration

Indexed keywords

CD86 ANTIGEN; INTERLEUKIN 12; KAINIC ACID; PROTEIN P35;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ASTROCYTOSIS; BRAIN INJURY; CELL ACTIVATION; CONTROLLED STUDY; DISEASE SEVERITY; FLOW CYTOMETRY; HIPPOCAMPUS; HUMAN; KNOCKOUT MOUSE; MALE; MICROGLIA; MOUSE STRAIN; NERVE DEGENERATION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STATISTICAL SIGNIFICANCE; WILD TYPE;

ANIMALS; ANTIGENS, CD95; BRAIN; EXCITATORY AMINO ACID AGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P35; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NERVE DEGENERATION; PROTEIN SUBUNITS;

EID: 5144225025     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2004.07.018     Document Type: Article

References (49)

1. F. Aloisi, R. De Simone, S. Columba-Cabezas, G. Penna, and L. Adorini Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells J. Immunol. 164 2000 1705 1712
2. B. Becher, V. Dodelet, V. Fedorowicz, and J.P. Antel Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro J. Clin. Invest. 98 1996 1539 1543
3. B. Becher, B.G. Durell, and R.J. Noelle Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 J. Clin. Invest. 110 2002 493 497
4. G. Bellone, and G. Trinchieri Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis J. Immunol. 153 1994 930 937
5. H.P. Brok, M. van Meurs, E. Blezer, A. Schantz, D. Peritt, G. Treacy, J.D. Laman, J. Bauer, and B.A. Hart Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody J. Immunol. 169 2002 6554 6563
6. M.F. Cano-Abad, M. Villarroya, A.G. Garcia, N.H. Gabilan, and M.G. Lopez Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death J. Biol. Chem. 276 2001 39695 39704
7. A. Castano, L.J. Lawson, S. Fearn, and V.H. Perry Activation and proliferation of murine microglia are insensitive to glucocorticoids in Wallerian degeneration Eur. J. Neurosci. 8 1996 581 588
8. C.C. Chao, and S. Hu Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures Dev. Neurosci. 16 1994 172 179
9. C.C. Chao, S. Hu, T.W. Molitor, E.G. Shaskan, and P.K. Peterson Activated microglia mediate neuronal cell injury via a nitric oxide mechanism J. Immunol. 149 1992 2736 2741
10. C.C. Chao, S. Hu, and P.K. Peterson Glia, cytokines, and neurotoxicity Crit. Rev. Neurobiol. 9 1995 189 205
11. Z. Chen, H.G. Ljunggren, N. Bogdanovic, I. Nennesmo, B. Winblad, and J. Zhu Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice Brain Res. 931 2002 135 145
12. C.A. Colton, and D.L. Gilbert Production of superoxide anions by a CNS macrophage, the microglia FEBS Lett. 223 1987 284 288
13. D.J. Cua, J. Sherlock, Y. Chen, C.A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, S. Zurawski, M. Wiekowski, S.A. Lira, D. Gorman, R.A. Kastelein, and J.D. Sedgwick Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
14. A. D'Andrea, M. Rengaraju, N.M. Valiante, J. Chehimi, M. Kubin, M. Aste, S.H. Chan, M. Kobayashi, D. Young, and E. Nickbarg Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells J. Exp. Med. 176 1992 1387 1398
15. M. Ding, K.G. Haglid, and A. Hamberger Quantitative immunochemistry on neuronal loss, reactive gliosis and BBB damage in cortex/striatum and hippocampus/amygdala after systemic kainic acid administration Neurochem. Int. 36 2000 313 318
16. S. Ebner, G. Ratzinger, B. Krosbacher, M. Schmuth, A. Weiss, D. Reider, R.A. Kroczek, M. Herold, C. Heufler, P. Fritsch, and N. Romani Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4 J. Immunol. 166 2001 633 641
17. M.G. Espey, O.N. Chernyshev, J.F. Reinhard Jr., M.A. Namboodiri, and C.A. Colton Activated human microglia produce the excitotoxin quinolinic acid NeuroReport 8 1997 431 434
18. K. Fassbender, A. Ragoschke, S. Rossol, A. Schwartz, O. Mielke, A. Paulig, and M. Hennerici Increased release of interleukin-12p40 in MS: association with intracerebral inflammation Neurology 51 1998 753 758
19. B.J.K. Franklin, and G. Paxinos The Mouse Brain in Stereotaxic Coordinates 1997 San Diego Academic Press
20. S. Freude, J. Hausmann, M. Hofer, N. Pham-Mitchell, I.L. Campbell, P. Staeheli, and A. Pagenstecher Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system J. Virol. 76 2002 12223 12232
21. M.K. Gately, L.M. Renzetti, J. Magram, A.S. Stern, L. Adorini, U. Gubler, and D.H. Presky The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses Annu. Rev. Immunol. 16 1998 495 521
22. B. Gran, G.X. Zhang, S. Yu, J. Li, X.H. Chen, E.S. Ventura, M. Kamoun, and A. Rostami IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination J. Immunol. 169 2002 7104 7110
23. S.E. Jacobsen, O.P. Veiby, and E.B. Smeland Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells J. Exp. Med. 178 1993 413 418
24. D.F. Jelinek, and J.K. Braaten Role of IL-12 in human B lymphocyte proliferation and differentiation J. Immunol. 154 1995 1606 1613
25. M. Kobayashi, L. Fitz, M. Ryan, R.M. Hewick, S.C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes J. Exp. Med. 170 1989 827 845
26. L.J. Lawson, V.H. Perry, and S. Gordon Microglial responses to physiological change: osmotic stress elevates DNA synthesis of neurohypophyseal microglia Neuroscience 56 1993 929 938
27. M.L. Mayer, G.L. Westbrook, and P.B. Guthrie Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones Nature 309 1984 261 263
28. J.O. McNamara The neurobiological basis of epilepsy Trends Neurosci. 15 1992 357 359
29. F.B. Meyer Calcium, neuronal hyperexcitability and ischemic injury Brain Res. Brain Res. Rev. 14 1989 227 243
30. W.T. Norton, D.A. Aquino, I. Hozumi, F.C. Chiu, and C.F. Brosnan Quantitative aspects of reactive gliosis: a review Neurochem. Res. 17 1992 877 885
31. S.L. O'Donnell, T.J. Frederick, J.K. Krady, S.J. Vannucci, and T.L. Wood IGF-I and microglia/macrophage proliferation in the ischemic mouse brain Glia 39 2002 85 97
32. D. Piani, K. Frei, K.Q. Do, M. Cuenod, and A. Fontana Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate Neurosci. Lett. 133 1991 159 162
33. D. Piani, M. Spranger, K. Frei, A. Schaffner, and A. Fontana Macrophage-induced cytotoxicity of N-methyl-d-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines Eur. J. Immunol. 22 1992 2429 2436
34. J.L. Ridet, S.K. Malhotra, A. Privat, and F.H. Gage Reactive astrocytes: cellular and molecular cues to biological function Trends Neurosci. 20 1997 570 577
35. A.D. Rogove, and S.E. Tsirka Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus Curr. Biol. 8 1998 19 25
36. J.D. Sedgwick, S. Schwender, H. Imrich, R. Dorries, G.W. Butcher, and V. ter Meulen Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system Proc. Natl. Acad. Sci. U. S. A. 88 1991 7438 7442
37. D. Sieburth, E.W. Jabs, J.A. Warrington, X. Li, J. Lasota, S. LaForgia, K. Kelleher, K. Huebner, J.J. Wasmuth, and S.F. Wolf Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5 Genomics 14 1992 59 62
38. E.J. Speckmann, J. Walden, and D. Bingmann [Functional implication of calcium ions in epileptic seizures. Antiepileptic effects of organic calcium antagonists] Arzneimittel-Forschung 39 1989 149 156
39. A.K. Stalder, A. Pagenstecher, N.C. Yu, C. Kincaid, C.S. Chiang, M.V. Hobbs, F.E. Bloom, and I.L. Campbell Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia J. Immunol. 159 1997 1344 1351
40. O. Steward, E.R. Torre, R. Tomasulo, and E. Lothman Neuronal activity up-regulates astroglial gene expression Proc. Natl. Acad. Sci. U. S. A. 88 1991 6819 6823
41. A. Suzumura, M. Sawada, and T. Takayanagi Production of interleukin-12 and expression of its receptors by murine microglia Brain Res. 787 1998 139 142
42. J. Tan, T. Town, T. Mori, Y. Wu, M. Saxe, F. Crawford, and M. Mullan CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase J. Neurosci. 20 2000 7587 7594
43. J. Tan, T. Town, and M. Mullan CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway J. Biol. Chem. 275 2000 37224 37231
44. Z. Tan, J. Levid, and S.S. Schreiber Increased expression of Fas (CD95/APO-1) in adult rat brain after kainate-induced seizures NeuroReport 12 2001 1979 1982
45. E.R. Torre, E. Lothman, and O. Steward Glial response to neuronal activity: GFAP-mRNA and protein levels are transiently increased in the hippocampus after seizures Brain Res. 631 1993 256 264
46. G. Trinchieri Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity Annu. Rev. Immunol. 13 1995 251 276
47. G. Trinchieri Interleukin-12: a cytokine at the interface of inflammation and immunity Adv. Immunol. 70 1998 83 243
48. S.E. Tsirka, A.D. Rogove, T.H. Bugge, J.L. Degen, and S. Strickland An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus J. Neurosci. 17 1997 543 552
49. S.F. Wolf, P.A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, and R.M. Hewick Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells J. Immunol. 146 1991 3074 3081