Evolution of hepatitis B virus during primary infection in humans: Transient generation of cytotoxic T-cell mutants

Gastroenterology

Volumn 127, Issue 4, 2004, Pages 1131-1138

  Whalley, Simon A ^a   Brown, David ^a   Webster, George J M ^a   Jacobs, Ruth ^a   Reignat, Stephanie ^a   Bertoletti, Antonio ^a   Teo, Chong Gee ^b   Emery, Vincent ^a   Dusheiko, Geoffrey M ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; HLA A ANTIGEN;

ARTICLE; BLOOD SAMPLING; CELL MUTANT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; GENETIC VARIABILITY; HAPLOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HLA SYSTEM; HUMAN; HUMAN CELL; MOLECULAR EVOLUTION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; VIRAL GENETICS; VIREMIA; VIRUS GENOME; VIRUS ISOLATION; VIRUS VIRULENCE;

EID: 5144222417     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.07.004     Document Type: Article

References (27)

1. M.A. Nowak, A.M. Hill, R. Boehme, H.C. Thomas, H. McDade Viral dynamics in hepatitis B virus infection Proc Natl Acad Sci U S A 93 1996 4398 4402
2. L.M. Wolters, B.E. Hansen, H.G. Niesters, D. DeHertogh, R.A. de Man Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B J Hepatol 37 2002 137 144
3. S. Zeuzem, R.A. de Man, P. Honkoop, W.K. Roth, S.W. Schalm, J.M. Schmidt Dynamics of hepatitis B virus infection in vivo J Hepatol 27 1997 431 436
4. S.A. Whalley, J.M. Murray, D. Brown, G.J. Webster, V.C. Emery, G.M. Dusheiko, A.S. Perelson Kinetics of acute hepatitis B virus infection in humans J Exp Med 193 2001 847 854
5. G. Missale, A. Redeker, J. Person, P. Fowler, S. Guilhot, H.J. Schlicht, C. Ferrari, F.V. Chisari HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis J Exp Med 177 1993 751 762
6. G.J. Webster, S. Reignat, M.K. Maini, S.A. Whalley, G.S. Ogg, A. King, D. Brown, P.L. Amlot, R. Williams, D. Vergani, G.M. Dusheiko, A. Bertoletti Incubation phase of acute hepatitis B in man dynamic of cellular immune mechanisms Hepatology 32 2000 1117 1124
7. V.C. Sheffield, D.R. Cox, L.S. Lerman, R.M. Myers Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes Proc Natl Acad Sci U S A 86 1989 232 236
8. K.A. Harris, C.G. Teo Diversity of hepatitis C virus quasispecies evaluated by denaturing gradient gel electrophoresis Clin Diagn Lab Immunol 8 2001 62 73
9. R.W. Hamming Coding and information theory 1986 Prentice-Hall Englebrook, NJ
10. A. Bertoletti, S. Southwood, R. Chesnut, A. Sette, M. Falco, G.B. Ferrara, A. Penna, C. Boni, F. Fiaccadori, C. Ferrari Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27 interaction with HLA and T-cell receptor Hepatology 26 1997 1027 1034
11. J. Salfeld, E. Pfaff, M. Noah, H. Schaller Antigenic determinants and functional domains in core antigen and e antigen from hepatitis B virus J Virol 63 1989 798 808
12. M. Sallberg, U. Ruden, B. Wahren, L.O. Magnius Immune recognition of linear antigenic regions within the hepatitis B pre-C and C-gene translation products using synthetic peptides J Med Virol 42 1994 7 15
13. A. Sette, A. Vitiello, P. Farness, J. Furze, J. Sidney, J.M. Claverie, H.M. Grey, R. Chesnut Random association between the peptide repertoire of A2.1 class I and several different DR class II molecules J Immunol 147 1991 3893 3900
14. C. Ferrari, A. Bertoletti, A. Penna, A. Cavalli, A. Valli, G. Missale, M. Pilli, P. Fowler, T. Giuberti, F.V. Chisari, F. Fiaccadori Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen J Clin Invest 88 1991 214 222
15. M.C. Jung, H.M. Diepolder, U. Spengler, E.A. Wierenga, R. Zachoval, R.M. Hoffmann, D. Eichenlaub, G. Frosner, H. Will, G.R. Pape Activation of a heterogeneous hepatitis B (HB) core and e antigen-specific CD4+ T-cell population during seroconversion to anti-HBe and anti-HBs in hepatitis B virus infection J Virol 69 1995 3358 3368
16. A. Bertoletti, F.V. Chisari, A. Penna, S. Guilhot, L. Galati, G. Missale, P. Fowler, H.J. Schlicht, A. Vitiello, R.C. Chesnut, F. Fiaccadori, C. Ferrari Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein J Virol 67 1993 2376 2380
17. R. Nayersina, P. Fowler, S. Guilhot, G. Missale, A. Cerny, H.J. Schlicht, A. Vitiello, R. Chesnut, J.L. Person, A.G. Redeker HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection J Immunol 150 1993 4659 4671
18. L.E. Gamadia, E.B. Remmerswaal, J.F. Weel, F. Bemelman, R.A. van Lier, I.J. Ten Berge Primary immune responses to human CMV a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease Blood 101 2003 2686 2692
19. P. Borrow, H. Lewicki, X. Wei, M.S. Horwitz, N. Peffer, H. Meyers, J.A. Nelson, J.E. Gairin, B.H. Hahn, M.B. Oldstone, G.M. Shaw Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus Nat Med 3 1997 205 211
20. V.C. Emery, A.F. Hassan-Walker, A.K. Burroughs, P.D. Griffiths Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts J Infect Dis 185 2002 1723 1728
21. P. Farci, A. Shimoda, A. Coiana, G. Diaz, G. Peddis, J.C. Melpolder, A. Strazzera, D.Y. Chien, S.J. Munoz, A. Balestrieri, R.H. Purcell, H.J. Alter The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies Science 288 2000 339 344
22. R.E. Phillips, S. Rowland-Jones, D.F. Nixon, F.M. Gotch, J.P. Edwards, A.O. Ogunlesi, J.G. Elvin, J.A. Rothbard, C.R. Bangham, C.R. Rizza, A.J. McMichael Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition Nature 354 1991 453 459
23. D.A. Price, P.J. Goulder, P. Klenerman, A.K. Sewell, P.J. Easterbrook, M. Troop, C.R. Bangham, R.E. Phillips Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection Proc Natl Acad Sci U S A 94 1997 1890 1895
24. D.H. O'Connor, T.M. Allen, T.U. Vogel, P. Jing, I.P. DeSouza, E. Dodds, E.J. Dunphy, C. Melsaether, B. Mothe, H. Yamamoto, H. Horton, N. Wilson, A.L. Hughes, D.I. Watkins Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection Nat Med 8 2002 493 499
25. A.L. Erickson, Y. Kimura, S. Igarashi, J. Eichelberger, M. Houghton, J. Sidney, D. McKinney, A. Sette, A.L. Hughes, C.M. Walker The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes Immunity 15 2001 883 895
26. M.K. Maini, S. Reignat, C. Boni, G.S. Ogg, A.S. King, F. Malacarne, G.J. Webster, A. Bertoletti T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection Eur J Immunol 30 2000 3067 3078
27. F. Buseyne, Y. Riviere The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytes Int Immunol 13 2001 941 950