Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro

British Journal of Pharmacology

Volumn 155, Issue 2, 2008, Pages 236-243

  Aughton, K L ^a   Hamilton Smith, K ^a   Gupta, J ^a   Morton, J S ^a   Wayman, C P ^a   Jackson, V M ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Arteries; Contraction; Female sexual arousal; Neuropeptides; Relaxation; Vagina

Indexed keywords

BREMELANOTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOTHALAMUS HORMONE; INTERMEDIN; LEUCINE; MELANIN CONCENTRATING HORMONE; MELANOCORTIN; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE; NEUROPEPTIDE Y; OXYTOCIN; PROLINE; RELCOVAPTAN; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST; VASOPRESSIN;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY MUSCLE; ARTICLE; FEMALE; FEMALE SEXUAL DYSFUNCTION; HYPOTHALAMUS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SEXUAL AROUSAL; SMOOTH MUSCLE RELAXATION; VAGINA MUCOSA;

ANIMALS; FEMALE; MODELS, MOLECULAR; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; NEUROPEPTIDE Y; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROTEIN CONFORMATION; RABBITS; VAGINA; VASOACTIVE INTESTINAL PEPTIDE;

EID: 51349164299     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.253     Document Type: Article

References (43)

1. Angulo J, Cuevas P, Cuevas B, Gupta S, Saenz De Tejada I (2004). Antidepressant-induced inhibition of genital vascular responses is reversed by vardenafil in female rabbits. J Pharmacol Exp Ther 310: 141-149.
2. Apostolakis EM, Lanz R, O'Malley BW (2004). Pituitary adenylate cyclase-activating peptide: a pivotal modulator of steroid-induced reproductive behavior in female rodents. Mol Endocrinol 18: 173-183.
3. Apostolakis EM, Riherd DN, O'Malley BW (2005). PAC1 receptors mediate pituitary adenylate cyclase-activating polypeptide- and progesterone-facilitated receptivity in female rats. Mol Endocrinol 19: 2798-2811.
4. Arletti R, Bertolini A (1985). Oxytocin stimulates lordosis behavior in female rats. Neuropeptides 6: 247-253.
5. Benelli A, Poggioli R, Luppi P, Ruini L, Bertolini A, Arletti R (1994). Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats. Neuropeptides 27: 245-250.
6. Blood CH, Shadiack AM, Bernstein JK, Herbert GW (2001). Compositions and methods for treatment of sexual dysfunction WO 2001/000224.
7. Caldwell JD (1992). Central oxytocin and female sexual behavior. Ann N Y Acad Sci 652: 166-179.
8. Caldwell JD, Jirikowski GF, Greer ER, Pedersen CA (1989). Medial preoptic area oxytocin and female sexual receptivity. Behav Neurosci 103: 655-662.
9. Caldwell JD, Johns JM, Faggin BM, Senger MA, Pedersen CA (1994). Infusion of an oxytocin antagonist into the medial preoptic area prior to progesterone inhibits sexual receptivity and increases rejection in female rats. Horm Behav 28: 288-302.
10. Caldwell JD, Prange AJ, Pedersen CA (1986). Oxytocin facilitates the sexual receptivity of estrogen-treated female rats. Neuropeptides 7: 175-189.
11. Clark JT (1992). Benextramine, a putative neuropeptide Y receptor antagonist, attenuates the termination of receptivity. Physiol Behav 52: 965-969.
12. Cragnolini A, Scimonelli T, Celis ME, Schioth HB (2000). The role of melanocortin receptors in sexual behavior in female rats. Neuropeptides 34: 211-215.
13. 1 receptor splice variants. Neurosci Abstract 726.21.
14. 1 receptor antagonist BIBP 3226. JPET 275: 136-142.
15. Gonzalez MI, Baker BI, Hole DR, Wilson CA (1998). Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with alpha-MSH, MCH and dopamine. Peptides 19: 1007-1016.
16. Gonzalez MI, Vaziri S, Wilson CA (1996). Behavioral effects of alpha-MSH and MCH after central administration in the female rat. Peptides 17: 171-177.
17. Graf AH, Schiechl A, Hacker GW, Hauser-Kronberger C, Steiner H, Arimura A et al. (1995). Helospectin and pituitary adenylate cyclase-activating polypeptide in the human vagina. Regul Pept 55: 277-286.
18. Hoyle CH, Stones RW, Robson T, Whitley K, Burnstock G (1996). Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. J Anat 188: 633-644.
19. Jorgensen JC, Sheikh SP, Forman A, Norgard M, Schwartz TW, Ottsen B (1989). Neuropeptide Y in the human female genital tract: localization and biological action. Am J Physiol 257: E220-E227.
20. Kim NN, Min K, Huang YH, Goldstein I, Traish AM (2002). Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina. Life Sci 71: 2909-2920.
21. Kim SW, Jeong SJ, Munarriz R, Kim NN, Goldstein I, Traish AM (2003). Role of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow. Int J Impot Res 15: 355-361.
22. Levin R (1991). VIP, vagina, clitoral and periurethral glans-an update on human female genital arousal. Exp Clin Endocrinol 98: 61-69.
23. Lew MJ, Angus JA (1995). Analysis of competitive agonist-antagonist interactions by nonlinear regression. Trends Pharmacol Sci 16: 328-337.
24. Maggi M, Genazzani AD, Giannini S, Torrisi C, Baldi E, Di Tomaso M et al. (1988). Vasopressin and oxytocin receptors in vagina, myometrium, and oviduct of rabbits. Endocrinol 122: 2970-2980.
25. Marin-Bivens CL, Kalra SP, Olster DH (1998). Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats. Regul Pept 75-76: 327-334.
26. Min K, Munarriz R, Berman J, Kim NN, Goldstein I, Traish AM et al. (2001). Hemodynamic evaluation of the female sexual arousal response in an animal model. J Sex Marital Ther 27: 557-565.
27. Min K, Munarriz R, Kim NN, Goldstein I, Traish A (2002). Effects of ovariectomy and estrogen and androgen treatment on sildenafil-mediated changes in female genital blood flow and vaginal lubrication in the animal model. Am J Obstet Gynecol 187: 1370-1376.
28. Min K, Munarriz R, Yerxa BR, Goldstein I, Shaver SR, Cowlen MS et al. (2003). Selective P2Y2 receptor agonists stimulate vaginal moisture in ovariectomized rabbits. Fertil Steril 79: 393-398.
29. Nocetto C, Cragnolini AB, Schioth HB, Scimonelli TN (2004). Evidence that the effect of melanocortins on female sexual behavior in preoptic area is mediated by the MC3 receptor; Participation of nitric oxide. Behav Brain Res 153: 537-541.
30. Park K, Ahn K, Lee S, Ryu S, Park Y, Azadzoi KM (2001). Decreased circulating levels of estrogen alter vaginal and clitoral blood flow and structure in the rabbit. Int J Impot Res 13: 116-124.
31. Park K, Goldstein I, Andry C, Siroky MB, Krane RJ, Azadzoi KM (1997). Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res 9: 27-37.
32. Pedersen CA, Boccia ML (2002). Oxytocin maintains as well as initiates female sexual behavior: effects of a highly selective oxytocin antagonist. Horm Behav 41: 170-177.
33. Pedersen CA, Boccia ML (2006). Vasopressin interactions with oxytocin in the control of female sexual behavior. Neuroscience 139: 843-851.
34. Pfaus JG, Shadiack A, Van Soest T, Tse M, Molinoff P (2004). Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proc Natl Acad Sci USA 101: 10201-10204.
35. Salonia A, Nappi RE, Pontillo M, Daverio R, Smeraldi A, Briganti A et al. (2005). Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women. Horm Behav 47: 164-169.
36. 5 inhibitors beyond erectile dysfunction. Int J Impot Res 19: 533-543.
37. Serradeil-Le Gal C, Wagnon J, Garcia C, Lacour C, Guiraudou P, Christophe B et al. (1993). Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors. J Clin Invest 92: 224-231.
38. Spengler D, Waeber C, Pantaloni C, Holshoer F, Bockaert J, Seeburg PH et al. (1993). Differential signal transduction by five splice variants of the PACAP receptor. Nature 365: 170-175.
39. Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL et al. (2002). Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 79: 785-792.
40. Tenmoku S, Otteson B, O'Hare MM, Shiekh S, Bardrum B, Hansen B et al. (1988). Interaction of NPY and VIP in regulation of myometrial blood flow and mechanical activity. Peptides 9: 269-275.
41. Thompson KL, Vincent SH, Miller RR, Colletti AE, Alvaro RF,Wallace MA et al. (1997). Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs. Drug Metab Dispos 25: 1113-1118.
42. Witt DM, Insel TR (1991). A selective oxytocin antagonist attenuates progesterone facilitation of female sexual behavior. Endocrinol 128: 3269-3276.
43. Ziessen T, Moncada S, Cellek S (2002). Characterisation of the non-nitregic NANC relaxation responses in the rabbit vaginal wall. Br J Pharmacol 135: 546-554.