Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5111-5114

  Xie, Yuli ^a   Raffo, Anthony ^a   Ichise, Masanori ^a   Deng, Shixian ^a   Harris, Paul E ^a   Landry, Donald W ^a  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

Dihydropyridone; Hypoglycemic; SARs; VMAT2

Indexed keywords

ANTIDIABETIC AGENT; DIHYDROTETRABENAZINE; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORTER 2;

ALKYLATION; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN RELEASE; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANIMALS; DIABETES MELLITUS; HYPOGLYCEMIC AGENTS; MALE; MOLECULAR STRUCTURE; PYRIDONES; RATS; RATS, INBRED LEW; STRUCTURE-ACTIVITY RELATIONSHIP; TETRABENAZINE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 51349161157     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.129     Document Type: Article

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