Effect of geldanamycin on the expression of signal proteins and heat shock proteins in normal mice lymphocytes

Tsitologiya

Volumn 50, Issue 7, 2008, Pages 629-635

  Novoselova, T V ^a   Cherenkov, D A ^a   Khrenov, M O ^a   Glushkova, O V ^a   Lunin, S M ^a   Novoselova, E G ^a   Fesenko, E E ^a  

^a INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

Author keywords

Geldanamycin; Heat shock proteins; I B ; Mice lymphocytes; NF B; pNF B; SAPK(JNK); Signal proteins; Western blot analysis

Indexed keywords

BENZOQUINONE DERIVATIVE; GELDANAMYCIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HSPB1 PROTEIN, MOUSE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROCYCLIC LACTAM; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROTEIN KINASE INHIBITOR; TUMOR PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; LASER; LYMPHOCYTE; MALE; METABOLISM; MOUSE; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; BENZOQUINONES; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; I-KAPPA B PROTEINS; LACTAMS, MACROCYCLIC; LASERS; LYMPHOCYTES; MALE; MAP KINASE KINASE 4; MICE; NEOPLASM PROTEINS; NF-KAPPA B; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SPLEEN;

EID: 51349129659     PISSN: 00413771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Beere H. M. 2005. Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J. Clin. Invest. 115 : 2633-2639.
2. Bradford M. A. 1976. A rapid sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 : 248-254.
3. Chavany C., Mimnaugh E., Miller P., Bitton R., Nguyen P., Trepei J., Whitesell L., Schnur R., Moyer J.D., Neckers L. 1996. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J. Biol. Chem. 271 : 4974-4977.
4. Conde A. G., Lau S. S., Dillmann W. H., Mestril R. 1997. Induction of heat shock proteins by tyrosine kinase inhibitors in rat cardiomyocytes and myogenic cells confers protection against simulated ischemia. Mol. Cell. Cardiol. 29 : 1927-1938.
5. Craig E. A., Weissman J. S., Horwicht A. L. 1994. Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell. 78 : 365-372.
6. DiDonato J., Mercurio F., Rosette C., Wu L. J., Suyang H., Ghost S., Karin M. 1996. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16: 1295-1304.
7. Gabai V.L., Meriin A. B., Yaglom J. A., Volloch V. Z., Sherman M. Y. 1998. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 438 : 1-4.
8. Gabai V. L., Sherman M. Y. 2002. Invited review: interplay between molecular chaperones and signaling pathways in survival of heat shock. J. Appl. Physiol. 92 : 1743-1748.
9. Guzhova I. V., Darieva Z. A., Rocha Melo A., MargulisB. A. 1997. Major stress protein Hsp70 interacts with NF-κB regulatory complex in human T-lymphoma cells. Cell Stress Chap. 2 : 132-139.
10. Hu J., Seeger C. 1996. Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase. Proc. Nat. Acad. Sci. USA. 93 : 1060-1064.
11. Laemmli U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227 : 680-685.
12. Luo J.-L., Kamata H., Karin M. 2005. IKK/NF-kappaB signaling: balancing life and death -a new approach to cancer therapy. J. Clin. Invest. 115:2625-2632.
13. Malhotra V., Shanlely T. P., Jean-Francois P., Welch W. J., Wong H. R. 2001. Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium. Cell. Mol. Biol. 25 : 92-97.
14. Marczin N. A., Papapetropoulos P., Catravas J.D. 1993. Tyrosine kinase inhibitors suppress endotoxin- and IL-1 beta-induced NO synthesis in aortic smooth muscle cells. Amer. J. Physiol. 265 : 1014-1018.
15. Nishina H., Wada T., Katada T. 2004. Physiological roles of SAPK(JNK) signaling pathway. Jap. Biolchem. Soc. 136 : 123-126.
16. Novoselova E. G., Glushkova O. V., Cherenkov D. A., Chudnovsky V. M., Fesenko E. E. 2006. Effects of low-power laser radiation on mice immunity, Photoderm. Photoimmun. Photothcr. 22 : 33-38.
17. Ran R., Lu A., Zhang L., Tang Y., Zhu H., Xu H., Feng Y., Han C., Zhou C., Rigby A. C., Sharp F. R. 2004. Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Develop. 18 : 1466-1481.
18. Schulte T. W., An W. G., Neckers I. M. 1997. Geldanamycin-induced destabilization of Raf-1 involves the proteasomc. Biochem. Biophys. Res. Commun. 239 : 655-659.
19. Supko J. G., Hickman R. L., Grever M. B., Malspeis L. 1995. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother. Pharmacol. 36 : 303-315.
20. Takimoto C H., Diggikar S. 2002. Heat shock protein and proteasome targeting agents. Hematol. Oncol. Clin. 16 : 1269-1285.
21. Vanden Berghe T., Kalai M., Geert van Loo, Declerq W., Vandenabeel P. 2003. Disruption of Hsp90 function reverts tumor nccrosis factor-induced necrosis to apoptosis. J. Biol. Chem. 278 : 5622-5629.
22. Whitesell L. P., Suthphi W. G., Blagoskionny M., Schute T., Neckers L. 1997. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene. 14 : 2809-2816.
23. Zhang G., Ghosh S. 2000. Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J. Endotoxin Res. 6 : 453-457.