The gut-brain-liver axis: A new option to treat obesity and diabetes?

Hepatology

Volumn 48, Issue 3, 2008, Pages 1011-1013

  Beraza, Naiara ^a   Trautwein, Christian ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIZOCILPINE; GLUCOSE; LONG CHAIN FATTY ACID COENZYME A LIGASE; TETRACAINE;

BRAIN FUNCTION; DIABETES MELLITUS; DIGESTION; ENERGY BALANCE; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; INTESTINE FUNCTION; LIPID BLOOD LEVEL; LIVER FUNCTION; LIVER METABOLISM; OBESITY; PRIORITY JOURNAL; SHORT SURVEY; VAGOTOMY;

EID: 51349123185     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22478     Document Type: Short Survey

References (9)

1. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007;117:13-23.
2. Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature 2006;444:854-859.
3. Badman MK, Flier JS. The gut and energy balance: Visceral allies in the obesity wars. Science 2005;307:1909-1914.
4. Lam TK, Schwartz GJ, Rossetti L. Hypothalamic sensing of fatty acids. Nat Neurosci 2005;8:579-584.
5. Coll AP, Farooqi IS, O'Rahilly S. The hormonal control of food intake. Cell 2007;129:251-262.
6. Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 2005;11:320-327.
7. Pocai A, Lam TK, Obici S, Gutierrez-Juarez R, Muse ED, Arduini A, et al. Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest 2006;116:1081-1091.
8. Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, et al. Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production. Nature 2008;452:1012-1016.
9. Matzinger D, Degen L, Drewe J, Meuli J, Duebendorfer R, Ruckstuhl N, et al. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 2000;46:688-693.