Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5087-5090

  Hutchings, Kim M ^a,b   Tran, Tuan P ^a,b   Ellsworth, Edmund L ^a,b   Watson, Brian M ^a,b   Sanchez, Joseph P ^a,b   Hollis Showalter, H D ^a,b   Stier, Michael A ^a,b   Shapiro, Martin ^a,c   Themis Joannides, E ^a,c   Huband, Michael ^a,c   Nguyen, Dai Q ^d   Maiti, Samarendra ^d   Li, Tingsheng ^d   Tailor, Jyoti ^d   Thomas, George ^d   Ha, Chan ^d   Singh, Rajeshwar ^d  

^a PFIZER INC   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Department of Antibacterial Pharmacology ^*  (Canada)

^d NAEJA Pharmaceuticals   (Canada)

Author keywords

Aminoquinazolinediones; Antibacterial; Fluoroquinolone; Topoisomerase

Indexed keywords

3 AMINOQUINAZOLINEDIONE DERIVATIVE; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; FLUOROPYRIMIDINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA GYRASE; DNA TOPOISOMERASES, TYPE II, BACTERIAL; FLUOROQUINOLONES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; QUINAZOLINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 51349104146     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.117     Document Type: Article

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