Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 4948-4951

  Shen, Hong C ^a   Taggart, Andrew K P ^a   Wilsie, Larissa C ^a   Waters, M Gerard ^a   Hammond, Milton L ^a   Tata, James R ^a   Colletti, Steven L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric agonists; GPR109A; Nicotinic acid receptor; Pyrazolopyrimidines

Indexed keywords

3 HYDROXYBUTYRIC ACID; NICOTINIC RECEPTOR; PYRAZOLOPYRIMIDINE DERIVATIVE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; NONHUMAN; STRUCTURE ANALYSIS;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; MOLECULAR STRUCTURE; NIACIN; NICOTINIC AGONISTS; PYRAZOLES; PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51349100188     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.039     Document Type: Article

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