Adenoviral β-adrenergic receptor kinase inhibitor gene transfer improves exercise capacity, cardiac contractility, and systemic inflammation in a model of pressure overload hypertrophy

Cardiovascular Drugs and Therapy

Volumn 22, Issue 5, 2008, Pages 373-381

  Gupta, Dipin ^a   Molina, Ezequiel J ^b   Palma, Jon ^b   Gaughan, John P ^b   Long, Walter ^b   Macha, Mahender ^c,d  

^a NEW YORK UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d NONE   (United States)

Author keywords

Beta adrenergic receptors; Exercise capacity; Experimental animal model; Gene therapy; Heart failure; Pressure overload hypertrophy

Indexed keywords

ADENOVIRUS VECTOR; ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR KINASE; BETA ADRENERGIC RECEPTOR KINASE INHIBITOR; BETA GALACTOSIDASE; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ARKCT GENE; CONTROLLED STUDY; DISEASE MODEL; EXERCISE TEST; EXERCISE TOLERANCE; GENE; GENE THERAPY; GENE TRANSFER; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE OVERLOAD; HEMODYNAMIC PARAMETERS; INFLAMMATION; INTRACORONARY INFUSION; MALE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANALYSIS OF VARIANCE; ANIMALS; ATRIAL NATRIURETIC FACTOR; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART FAILURE; HEMODYNAMICS; HYPERTROPHY, LEFT VENTRICULAR; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MYOCARDIAL CONTRACTION; NATRIURETIC PEPTIDES; PEPTIDES; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 51349099240     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-008-6123-x     Document Type: Article

References (25)

1. KL Pierce RT Premont RJ Lefkowitz 2002 Seven-transmembrane receptors Nat Rev Mol Cell Biol 3 639 650
2. G Iaccarino RJ Lefkoiwtz WJ Koch G Myocardial 1999 Protein-coupled receptor kinases: Implications for heart failure therapy Proc Assoc Am Physicians 111 399 405
3. M Ungerer M Bohm JS Elce E Erdmann MJ Lohse 1993 Altered expression of β-adrenergic receptor kinase and β1-adrenergic receptors in the failing human heart Circulation 87 454 463
4. WJ Koch HA Rockman P Samama RA Hamilton RA Bond CA Milano 1995 Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor Science 268 1350 1353
5. WJ Koch J Inglese WC Stone RJ Lefkowitz 1993 The binding site for βγ subunits of heterotrimeric G proteins on the β-adrenergic receptor kinase J Biol Chem 268 8256 8260
6. SA Akhter CA Skaer AP Kypson PH McDonald KC Peppel DD Glower 1997 Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer Proc Natl Acad Sci U S A 94 12100 12105
7. AS Shah DC White S Emani AP Kypson RE Lilly K Wilson 2001 In vivo ventricular gene delivery of a β-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction Circulation 103 1311 1316
8. ML Williams JA Hata J Schroder E Rampersaud J Petrofski A Jakoi 2004 Targeted β-adrenergic receptor kinase (βARK1) inhibition by gene transfer in failing human hearts Circulation 109 1590 1593
9. MA Croyle DJ Anderson BJ Roessler GL Amidon 1998 Development of a highly efficient purification process for recombinant adenoviral vectors for oral gene delivery Pharm Dev Technol 3 365 372
10. TI Musch RL Moore M Riedy P Burke R Zelis ME Leo 1988 Glycogen concentrations and endurance capacity of rats with chronic heart failure J Appl Physiol 643 1153 1159
11. TI Musch MR Ghaul V Tranchitella R Zelis 1990 Skeletal muscle depletion during submaximal exercise in rats with chronic heart failure Basic Res Cardiol 85 606 618
12. MR Bristow 2000 Beta-adrenergic receptor blockade in chronic heart failure Circulation 101 558 569
13. JP Morgan 1991 Abnormal intercellular modulation of calcium as a major cause of cardiac contractility dysfunction N Engl J Med 325 625 632
14. H Kubo KB Margulies V Piacentino 3rd JP Gaughan SR Houser 2001 Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance Circulation 104 1012 1018
15. V Jayasankar YJ Woo LT Bish TJ Pirolli S Chatterjee MF Berry 2003 Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure Circulation 108 230 236
16. Aggarwal B, Reddy S. In: Nicola NA, editor. Guidebook to cytokines and their receptors. NewYork: Oxford University Press; 1994. p. 110.
17. DC White JA Hata AS Shah DD Glower RJ Lefkowitz WJ Koch 2000 Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction Proc Natl Acad Sci U S A 97 5428 5433
18. HA Rockman KR Chien DJ Choi G Iaccarino JJ Hunter J Ross Jr 1998 Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice Proc Natl Acad Sci U S A 95 7000 7005
19. H Tachibana SV Naga Prasad RJ Lefkowitz WJ Koch HA Rockman 2005 Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure Circulation 111 591 597
20. AD Eckhart WJ Koch 2002 Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes Mol Ther 5 74 79
21. B Levine J Kalman L Mayer HM Fillit M Packer 1990 Elevated circulating levels of tumor necrosis factor in severe congestive heart failure N Engl J Med 323 236 241
22. A Matsumori T Yamada H Suzuki Y Matoba S Sasayama 1994 Increased circulating cytokines in patients with myocarditis and cardiomyopathy Br Heart J 72 561 566
23. P Aukrust T Ueland E Lien K Bendtzen F Müller AK Andreassen 1999 Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy Am J Cardiol 83 376 382
24. E Barr J Carroll AM Kalynych SK Tripathy K Kozarsky JM Wilson 1994 Efficient catheter-mediated gene transfer into the heart using replication-deficient adenovirus Gene Ther 1 51 58
25. EC Svensson DJ Marshall K Woodard H Lin F Jiang L Chu 1999 Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated vectors Circulation 99 201 205