Predictors of nonalcoholic steatohepatitis in patients undergoing bariatric surgery: when is liver biopsy indicated?

Surgery for Obesity and Related Diseases

Volumn 4, Issue 5, 2008, Pages 612-617

  Helling, Thomas S ^a   Helzberg, John H ^a   Nachnani, Jagdish S ^a   Gurram, Krishna ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin resistance; Liver biopsy; Morbid obesity; NAFLD; NASH; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Predictors

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; IRON; PREALBUMIN; TRIACYLGLYCEROL;

ADULT; AGE; AGED; ARTICLE; BARIATRIC SURGERY; BODY MASS; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HYPERTENSION; INTRAOPERATIVE PERIOD; LIVER BIOPSY; LIVER FIBROSIS; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; MULTIVARIATE ANALYSIS; NON INVASIVE MEASUREMENT; NONALCOHOLIC FATTY LIVER; PREDICTION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RACE DIFFERENCE; ROUX Y ANASTOMOSIS; SCORING SYSTEM; SEX DIFFERENCE; STOMACH BYPASS; UNIVARIATE ANALYSIS;

ADULT; AGED; BARIATRIC SURGERY; BIOPSY; DIAGNOSIS, DIFFERENTIAL; FATTY LIVER; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOPERATIVE CARE; LIVER; MALE; MIDDLE AGED; OBESITY, MORBID; REPRODUCIBILITY OF RESULTS; YOUNG ADULT;

EID: 51349089726     PISSN: 15507289     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.soard.2007.11.007     Document Type: Article

References (35)

1. Braillon A., Capron J.P., Herve M.A., Degott C., and Quenum C. Liver in obesity. Gut 26 (1985) 133-139
2. Luyckx F.H., Desaive C., Thiry A., et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes 22 (1998) 222-226
3. Day C.P., and James O.F.W. Hepatic steatosis: innocent bystander or guilty party?. Hepatology 27 (1998) 1463-1466
4. Matteoni C.A., Younossi Z.M., Gramlich T., Boparai N., Liu Y.C., and McCullough A.J. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116 (1999) 1413-1419
5. Fassio E., Alvarez E., Dominguez N., Landeira G., and Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40 (2004) 820-826
6. Sjöstrom L., Lindroos A.K., Peltonen M., et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351 (2004) 2683-2693
7. Steinbrook R. Surgery for severe obesity. N Engl J Med 350 (2004) 1075-1079
8. Luyckx F.H., Scheen A.J., Desaive C., Thiry A., and Lefebvre P.J. Parallel reversibility of biological markers of the metabolic syndrome and liver steatosis after gastroplasty-induced weight loss in severe obesity [abstract]. J Clin Endocrinol Metab 84 (1999) 4293
9. Clark J.M., Alkhuraishi A.R., Solga S.F., Alli P., Diehl A.M., and Magnuson T.H. Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease. Obes Res 13 (2005) 1180-1186
10. Kral J.G., Thung S.N., Biron S., et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery 135 (2004) 48-58
11. Brunt E.M., Janney C.G., Di Bisceglie A.M., Neuschwander-Tetri B.A., and Bacon B.R. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94 (1999) 2467-2474
12. Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 40 (2004) 1387-1395
13. Hanley A.J.G., Williams K., Festa A., Wagenknecht L.E., D'Agostino R.B., and Haffner S.M. Liver markers and development of the metabolic syndrome. Diabetes 54 (2005) 3140-3147
14. Assy N., Kaita K., Mymin D., Levy C., Rosser B., and Minuk G. Fatty infiltration of liver in hyperlipidemic patients. Dig Dis Sci 45 (2000) 1929-1934
15. Marchesini G., Brizi M., Morselli-Labate A.M., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 107 (1999) 450-455
16. Donnelly K.L., Smith C.I., Schwarzenberg S.J., Jessurun J., Boldt M.D., and Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115 (2005) 1343-1351
17. Chitturi S., Abeygunasekera S., Farrell G.C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 35 (2002) 373-379
18. Fletcher J.P., Little J.M., and Guest P.K. A comparison of serum transferrin and serum prealbumin as nutritional parameters. J Parenter Enteral Nutr 11 (1987) 144-147
19. Kral J.G., Lundholm K., Sjöstrom L., Bjorntorp P., and Schersten T. Hepatic lipid metabolism in severe human obesity. Metabolism 26 (1977) 1025-1031
20. Charlton M., Sreekumar R., Rasmussen D., Lindor K., and Nair K.S. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 35 (2002) 898-904
21. Barle H., Hammarqvist F., Westman B., et al. Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response. Clin Sci (Lond) 110 (2006) 93-99
22. Kang H., Greenson J.K., Omo J.T., et al. Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLD. Am J Gastroenterol 101 (2006) 2247-2253
23. Frantzides C.T., Carlson M.A., Moore R.E., et al. Effect of body mass index on nonalcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery. J Gastrointest Surg 8 (2004) 849-855
24. Angulo P., Keach J.C., Batts K.P., and Lindor K.D. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30 (1999) 1356-1362
25. Boza C., Riquelme A., Ibanez L., et al. Predictors of nonalcoholic steatohepatitis (NASH) in obese patients undergoing gastric bypass. Obes Surg 15 (2005) 1148-1153
26. Mofrad P., Contos M.J., Haque M., et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 37 (2003) 1286-1292
27. Shalhub S., Parsee A., Gallagher S.F., et al. The importance of routine liver biopsy in diagnosing nonalcoholic steatohepatitis in bariatric patients. Obes Surg 14 (2004) 54-59
28. Ratziu V., Charlotte F., Heurtier A., et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 128 (2005) 1898-1906
29. Lee D.S., Evans J.C., Robins S.J., et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk. Arterioscler Thromb Vasc Biol 27 (2007) 4-7
30. Puukka K., Hietala J., Koivisto H., et al. Additive effects of moderate drinking and obesity on serum gamma-glutamyl transferase activity. Am J Clin Nutr 83 (2006) 1351-1354
31. Dixon J.B., Bhathal P.S., and O'Brien P.E. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 121 (2001) 91-100
32. Brolin R.E., Bradley L.J., and Taliwal R.V. Unsuspected cirrhosis discovered during elective obesity operations. Arch Surg 133 (1998) 84-88
33. Saadeh S., Younossi Z.M., Remer E.M., et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 123 (2002) 745-750
34. Angulo P., Hui J.M., Marchesini G., et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 45 (2007) 846-854
35. Wilson S., and Chalasani N. Noninvasive markers of advanced histology in nonalcoholic fatty liver disease: are we there yet?. Gastroenterology 133 (2007) 1378-1379