The effects of patient function and dependence on costs of care in Alzheimer's disease

Journal of the American Geriatrics Society

Volumn 56, Issue 8, 2008, Pages 1497-1503

  Zhu, Carolyn W ^a,b   Leibman, Christopher ^c   McLaughlin, Trent ^c   Scarmeas, Nikolaos ^d,e   Albert, Marilyn ^f   Brandt, Jason ^f   Blacker, Deborah ^g   Sano, Mary ^a,b   Stern, Yaakov ^d,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c ELAN PHARMACEUTICALS   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Cost; Dependence; Function

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BLESSED DEMENTIA RATING SCALE; CAREGIVER; DAILY LIFE ACTIVITY; DEMOGRAPHY; DEPENDENCE SCALE; DETERIORATION; DISABILITY; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL STATUS; HEALTH CARE COST; HOSPITALIZATION COST; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; OBSERVATIONAL STUDY; RATING SCALE;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CROSS-SECTIONAL STUDIES; DISABILITY EVALUATION; FEMALE; GERIATRIC ASSESSMENT; HEALTH CARE COSTS; HOSPITALS, UNIVERSITY; HUMANS; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; UNITED STATES;

EID: 51249105328     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2008.01798.x     Document Type: Article

References (35)

1. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968 114 : 797 811.
2. Lawton MP, Brody EM. Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 1969 9 : 179 186.
3. Katz S, Akpom CA. 12. Index of ADL. Med Care 1976 14 : 116 118.
4. Stern Y, Hesdorffer D, Sano M et al. Measurement and prediction of functional capacity in Alzheimer's disease. Neurology 1990 40 : 8 14.
5. Stern Y, Albert SM, Sano M et al. Assessing patient dependence in Alzheimer's disease. J Gerontol 1994 49 : M216 M222.
6. Brickman AM, Riba A, Bell K et al. Longitudinal assessment of patient dependence in Alzheimer disease. Arch Neurol 2002 59 : 1304 1308.
7. Holtzer R, Wegesin DJ, Albert SM et al. The rate of cognitive decline and risk of reaching clinical milestones in Alzheimer disease. Arch Neurol 2003 60 : 1137 1142.
8. Sarazin M, Stern Y, Berr C et al. Neuropsychological predictors of dependency in patients with Alzheimer disease. Neurology 2005 64 : 1027 1031.
9. Taylor DH Jr., Schenkman M, Zhou J et al. The relative effect of Alzheimer's disease and related dementias, disability, and comorbidities on cost of care for elderly persons. J Gerontol B Psychol Sci Soc Sci 2001 56 : S285 S293.
10. Small GW, McDonnell DD, Brooks RL et al. The impact of symptom severity on the cost of Alzheimer's disease. J Am Geriatr Soc 2002 50 : 321 327.
11. Jonsson L, Eriksdotter Jonhagen M, Kilander L et al. Determinants of costs of care for patients with Alzheimer's disease. Int J Geriatr Psychiatry 2006 21 : 449 459.
12. Hill J, Fillit H, Thomas SK et al. Functional impairment, healthcare costs and the prevalence of institutionalisation in patients with Alzheimer's disease and other dementias. Pharmacoeconomics 2006 24 : 265 280.
13. Zhu CW, Scarmeas N, Torgan R et al. Clinical characteristics and longitudinal changes of informal cost of Alzheimer's disease in the community. J Am Geriatr Soc 2006 54 : 1596 1602.
14. Zhu CW, Scarmeas N, Torgan R et al. Longitudinal study of effects of patient characteristics on direct costs in Alzheimer disease. Neurology 2006 67 : 998 1005.
15. Murman DL, Von Eye A, Sherwood PR et al. Evaluated need, costs of care, and payer perspective in degenerative dementia patients cared for in the United States. Alzheimer Dis Assoc Disord 2007 21 : 39 48.
16. Stern Y, Folstein M, Albert M et al. Multicenter study of predictors of disease course in Alzheimer disease (the "predictors study"). I. Study design, cohort description, and intersite comparisons. Alzheimer Dis Assoc Disord 1993 7 : 3 21.
17. Richards M, Folstein M, Albert M et al. Multicenter study of predictors of disease course in Alzheimer disease (the "predictors study"). II. Neurological, psychiatric, and demographic influences on baseline measures of disease severity. Alzheimer Dis Assoc Disord 1993 7 : 22 32.
18. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975 12 : 189 198.
19. Stern Y, Sano M, Paulson J et al. Modified Mini-Mental State Examination: Validity and reliability. Neurology 1987 37 : 179.
20. Mirra SS. The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: A commentary. Neurobiol Aging 1997 18 : S91 S94.
21. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997 18 : S1 S2.
22. Menzin J, Lang K, Friedman M et al. The economic cost of Alzheimer's disease and related dementias to the California Medicaid program ("Medi-Cal") in 1995. Am J Geriatr Psychiatry 1999 7 : 300 308.
23. Penrod JD, Kane RL, Finch MD et al. Effects of post hospital Medicare home health and informal care on patient functional status. Health Serv Res 1998 33 : 513 529.
24. Council of Economic Advisers, Economic Report of the President. 2006 : Washington, DC.
25. Devanand DP, Miller L, Richards M et al. The Columbia University Scale for Psychopathology in Alzheimer's disease. Arch Neurol 1992 49 : 371 376.
26. Stern Y, Tang MX, Albert MS et al. Predicting time to nursing home care and death in individuals with Alzheimer disease. JAMA 1997 277 : 806 812.
27. Stern MB, Hurting HI. The clinical characteristics of Parkinson's disease and parkinsonian syndromes: Diagnosis and assessment. In : Stern MB, Hurtig HI The Comprehensive Management of Parkinson's Disease. New York : PMA Corp, 1978, pp 3 50.
28. Richards M, Marder K, Bell K et al. Interrater reliability of extrapyramidal signs in a group assessed for dementia. Arch Neurol 1991 48 : 1147 1149.
29. Charlson ME, Pompei P, Ales KL et al. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987 40 : 373 383.
30. Stern Y, Liu X, Albert M et al. Application of a growth curve approach to modeling the progression of Alzheimer's disease. J Gerontol A Biol Sci Med Sci 1996 51A : M179 M184.
31. Zhu C, Scarmeas N, Torgan R et al. Home health and informal care utilization and costs over time in Alzheimer's disease. Home Health Care Serv Quart 2008 27 : 1 20.
32. Corder LS, Woodbury MA, Manton KG. Proxy response patterns among the aged: Effects on estimates of health status and medical care utilization from the 1982-1984 long-term care surveys. J Clin Epidemiol 1996 49 : 173 182.
33. Neumann PJ, Araki SS, Gutterman EM. The use of proxy respondents in studies of older adults: Lessons, challenges, and opportunities. J Am Geriatr Soc 2000 48 : 1646 1654.
34. Fisher ES, Wennberg DE, Stukel TA et al. The implications of regional variations in medicare spending. Part 1: The content, quality, and accessibility of care. Ann Intern Med 2003 138 : 273 287.
35. Harrow BS, Mahoney DF, Mendelsohn AB et al. Variation in cost of informal caregiving and formal-service use for people with Alzheimer's disease. Am J Alzheimers Dis Other Demen 2004 19 : 299 308.