In vitro evaluation of the growth inhibitory activities of 15 drugs against Babesia gibsoni (Aomori strain)

Veterinary Parasitology

Volumn 157, Issue 1-2, 2008, Pages 1-8

  Matsuu, Aya ^a   Yamasaki, Masahiro ^b   Xuan, Xuenan ^c   Ikadai, Hiromi ^d   Hikasa, Yoshiaki ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^d KITASATO UNIVERSITY   (Japan)

Author keywords

Babesia gibsoni; Chemical drugs; Continuous culture; Growth inhibitory activity

Indexed keywords

ANTIPROTOZOAL AGENT; ARTESUNATE; ATOVAQUONE; AZITHROMYCIN; CHLOROQUINE; CLINDAMYCIN PHOSPHATE; CLOTRIMAZOLE; DEFEROXAMINE MESYLATE; DIHYDROARTEMISININ; DIMINAZENE ACETURATE; DOXYCYCLINE; KETOCONAZOLE; METRONIDAZOLE; MINOCYCLINE; PENTAMIDINE ISETHIONATE; QUININE HEMISULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; BABESIA; BABESIA GIBSONI; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOG; DRUG SENSITIVITY; ERYTHROCYTE; GROWTH INHIBITION; IC 50; IN VITRO STUDY; NONHUMAN; PARASITE ISOLATION; PARASITEMIA;

ANIMALS; ANTIPROTOZOAL AGENTS; BABESIA; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG;

ARTESUNATE; BABESIA GIBSONI; BOVINAE;

EID: 51249097703     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2008.07.023     Document Type: Article

References (41)

1. Birkenheuer A.J., Levy M.G., and Breitschwedt E.B. Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs. J. Vet. Intern. Med. 18 (2004) 494-498
2. Boozer A.L., and Macintire D.K. Canine babesiosis. Vet. Clin. North Am. Small Anim. Pract. 33 (2003) 885-904
3. Bork S., Yokoyama N., Maysuo T., Claveria F.G., Fujisaki K., and Igarashi I. Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture. J. Parasitol. 89 (2003) 604-606
4. Bork S., Yokoyama N., Matsuo T., Claveria F.G., Fujisaki K., and Igarashi I. Clotrimazole, ketoconazole, and clodinafop-propargyl inhibit the in vitro growth of Babesia bigemina and Babesia bovis (Phylum Apicomplexa). Parasitology 127 (2003) 311-315
5. Brasseur P., Lecoublet S., Kapel N., Favennec L., and Ballet J. In vitro evaluation of drug susceptibilities of Babesia divergens isolates. Antimicrob. Agent Chemother. 42 (1998) 818-820
6. Dahl E.L., and Rosenthal P.L. Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 24 (2008) 279-284
7. Divo A.A., Geary T.G., and Jensen J.B. Oxygen- and time-dependent effects of antibiotics and selected mitochondrial inhibitors on Plasmodium falciparum in culture. Antimicrob. Agent Chemother. 27 (1985) 21-27
8. Farwell G.E., LeGrand E.K., and Cobb C.C. Clinical observations of Babesia gibsoni and Babesia canis infections in dogs. J. Am. Vet. Med. Assoc. 180 (1982) 507-511
9. Fichera M., and Roos D.S. A plastid organelle as a drug target in apicomplexan parasites. Nature 390 (1997) 407-409
10. Fowler J.L., Ruff M.D., Fernau R.C., and Furusho Y. Babesia gibsoni: chemotherapy in dogs. Am. J. Vet. Res. 33 (1972) 1109-1114
11. Groves M.G., and Dennis G. Babesia gibsoni: field and laboratory studies of canine infections. Exp. Parasitol. 31 (1972) 153-159
12. Groves M.G., and Vanniasingham J.A. Treatment of Babesia gibsoni infections with phenamidine isethionate. Vet. Rec. 86 (1970) 8-10
13. Ikadai H., Tanaka H., Shibahara N., Matsuu A., Uechi M., Itoh N., Oshiro S., Kudo N., Igarashi I., and Oyamada T. Molecular evidence of infections with Babesia gibsoni parasites in Japan and evaluation of the diagnostic potential of a loop-mediated isothermal amplification method. J. Clin. Microbiol. 42 (2004) 2465-2469
14. Kawai S., Igarashi I., Avarzed K., Miyazawa K., Ikadai H., Nagasawa K., Fujisaki T., Mikami N., Suzuki N., and Matsuda H. Ultrastructural characteristics of Babesia caballi in equine erythrocytes in vitro. Parasitol. Res. 48 (1999) 794-799
15. Kjemtrump A.M., Kocan A.A., Whitworth L., Meinkoth J., Birkenheuer A.J., Cummings M.K., Stockham S.L., Irizarri-Rovira A., and Conrad P.A. There are at least three genetically distinct small piroplasms from dogs. Int. J. Parasitol. 30 (2000) 1501-1505
16. Lehtinen L.E., Birkenheuer A.J., Droleskey R.E., and Holman P.J. In vitro cultivation of a newly recognized Babesia sp. in dogs in North Carolina. Vet. Parasotol. 151 (2008) 150-157
17. Losson B., and Patz R. Babesia divergens: activity of long-acting oxytetracycline in the gerbil, Meriones unguiculatus. Ann. Rech. Vet. 20 (1989) 501-507
18. Matsuu A., Koshida Y., Kawahara M., Inoue K., Ikadai H., Hikasa Y., Okano S., and Higuchi S. Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro. Vet. Parasitol. 124 (2004) 9-18
19. Matsuu A., Kawabe A., Koshida Y., Ikadai H., Okano S., and Higuchi S. Incidence of canine Babesia gibsoni infection and subclinical infection among Tosa dogs in Aomori Prefecture, Japan. J. Vet. Med. Sci. 66 (2004) 893-897
20. Meshnick S.R., Taylor T.E., and Kamchonwongpaisan S. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol. Rev. 60 (1996) 301-315
21. Mishina Y.V., Krishna S., Haynes R.K., and Meade J.C. Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth. Antimicrob. Agents Chemother. 51 (2007) 1852-1854
22. Muhlnickel C.J., Jefferies R.J., Morgan-Ryan U.M., and Irwin P.J. Babesia gibsoni infection in three dogs in Victoria. Aust. Vet. J. 80 (2002) 606-610
23. Murase T., Hashimoto T., Ueda T., and Maeda T. Multiplication of Babesia gibsoni in in vitro culture and its relation to hemolysis of infected erythrocytes. J. Vet. Med. Sci. 53 (1991) 759-760
24. Murnigsih T., Subeki M.H., Takahashi K., Yamasaki M., Yamato O., Maede Y., Katakura K., Suzuki M., Kobayashi S., and Chairul Y.T. Evaluation of the inhibitory activities of the extracts of Indonesian traditional medicinal plants against Plasmodium falciparum and Babesia gibsoni. J. Vet. Med. Sci. 67 (2005) 829-831
25. Nagai A., Yokoyama N., Matsuo T., Bork S., Hirata H., Xuan X., Zhu Y., Claveria F.G., Fujisaki K., and Igarashi I. Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures. Antimicrob. Agents Chemother. 47 (2003) 800-803
26. Nakornchai S., and Konthiang P. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 100 (2006) 185-191
27. Noedle H., Krudsood S., Leowattana W., Tangpukdee N., Thanachartwet W., Looareesuwan S., Miller R.S., Fukuda M., Jongsakul K., Yingyuen K., Sriwichai S., Ohrt C., and Knirsch C. In vitro antimalarial activity of azithromycin, artesunate, and quinine in combination and correlation with clinical outcome. Antimicrob. Agents Chemother. 51 (2007) 651-656
28. Pradines B., Rogier C., Fusai T., Mosnier J., Daries W., Barret E., and Parzy D. In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron. Animicrob. Agents Chemother. 45 (2001) 1746-1750
29. Pradines B., Tall A., Ramiandrasa F., Spiegel A., Sokhna C., Fusai T., Mosnier J., Daries W., Trape J.F., Kunesch G., Parzy D., and Rogier C. In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum. J. Antimicob. Chemother. 57 (2006) 1093-1099
30. Slater A.F.G. Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol. Ther. 57 (1993) 203-235
31. Subeki M.H., Takahashi K., Nabeta K., Yamasaki M., Maede Y., and Katakura K. Screening of Indonesian medical plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica. J. Nat. Prod. 70 (2007) 1654-1657
32. Sunaga F., Namikawa K., and Kanno Y. Continuous in vitro culture of erythrocytic stages of Babesia gibsoni and virulence of the cultivated parasite. J. Vet. Med. Sci. 64 (2002) 571-575
33. Suzuki K., Wakabayashi H., Takahashi M., Fukushima K., Yabuki A., and Endo Y. A possible treatment strategy and clinical factors to estimate the treatment response in Babesia gibsoni infection. J. Vet. Med. Sci. 69 (2007) 563-568
34. Taboada J., and Merchant S.R. Babesiosis of companion animal and man. Vet. Clin. North Am. Small Anim. Pract. 21 (1991) 103-123
35. Tiffert T., Ginsburg H., Krugliak M., Elford B.C., and Lew V.L. Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 331-336
36. Vercammen F., Deken R.D., and Maes L. Prophylactic treatment of experimental canine babesiosis (Babesia canis) with doxycycline. Vet. Parasitol. 66 (1996) 251-255
37. Vial H.J., and Gorenflot A. Chemotherapy against babesiosis. Vet. Parasitol. 138 (2006) 147-160
38. Woodrow C.J., Haynes R.K., and Krishna S. Artemisinins. Postgrad. Med. J. 81 (2005) 71-78
39. Wulansari R., Wijaya A., Ano H., Horii Y., Nasu T., Yamane S., and Makimura S. Clindamycin in the treatment of Babesia gibsoni infections in dogs. J. Am. Anim. Hosp. Assoc. 39 (2003) 558-562
40. Yang D.M., and Liew F.Y. Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis. Parasitology 106 (1993) 7-11
41. Zweygarth E., Niekerk C.J., and Waal D.T. Continuous in vitro cultivation of Babesia caballi in serum-free medium. Parasitol. Res. 85 (1999) 413-416