Effect of small intestinal glucose load on plasma ghrelin in healthy men

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 2, 2008, Pages

  Cukier, Kimberly ^a   Pilichiewicz, Amelia N ^a   Chaikomin, Reawika ^a   Brennan, Ixchel M ^a   Wishart, Judith M ^a   Rayner, Christopher K ^a   Jones, Karen L ^a   Horowitz, Michael ^a   Feinle Bisset, Christine ^a  

^a NONE

Author keywords

Glycemia; Intraduodenal glucose loads; Plasma insulin

Indexed keywords

GHRELIN; GLUCOSE; INSULIN; SODIUM CHLORIDE;

ADULT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; GLUCOSE BLOOD LEVEL; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SMALL INTESTINE; BLOOD; DIGESTIVE TRACT INTUBATION; DOUBLE BLIND PROCEDURE; DUODENUM; KINETICS; METABOLISM; RANDOMIZATION; REFERENCE VALUE;

ADULT; BLOOD GLUCOSE; DOUBLE-BLIND METHOD; DUODENUM; GHRELIN; GLUCOSE SOLUTION, HYPERTONIC; HUMANS; INSULIN; INTUBATION, GASTROINTESTINAL; KINETICS; MALE; RANDOM ALLOCATION; REFERENCE VALUES; SALINE SOLUTION, HYPERTONIC;

EID: 51149114013     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00169.2008     Document Type: Article

References (21)

1. Arafat AM, Perschel FH, Otto B, Weickert MO, Rochlitz H, Schofl C, Spranger J, Mohlig M, Pfeiffer AF. Glucagon suppression of ghrelin secretion is exerted at hypothalamus-pituitary level. J Clin Endocrinol Metab 91: 3528-3533, 2006.
2. Bland JM, Altman DG. Calculating correlation coefficients with repeated observations: Part 2-Correlation between subjects. BMJ 310: 633, 1995.
3. Blom WA, Lluch A, Vinoy S, Stafleu A, van den Berg R, Holst JJ, Kok FJ, Hendriks HF. Effects of gastric emptying on the postprandial ghrelin response. Am J Physiol Endocrinol Metab 290: E389-E395, 2006.
4. Brener W, Hendrix TR, McHugh PR. Regulation of the gastric emptying of glucose. Gastroenterology 85: 76-82, 1983.
5. Caixas A, Bashore C, Nash W, Pi-Sunyer F, Laferrere B. Insulin, unlike food intake, does not suppress ghrelin in human subjects. J Clin Endocrinol Metab 87: 1902-1906, 2002.
6. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719, 2001.
7. Erdmann J, Lippl F, Schusdziarra V. Differential effect of protein and fat on plasma ghrelin levels in man. Regul Pept 116: 101-107, 2003.
8. Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV, Sherwin RS. The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab 284: E313-E316, 2003.
9. Greenman Y, Golani N, Gilad S, Yaron M, Limor R, Stern N. Ghrelin secretion is modulated in a nutrient- and gender-specific manner. Clin Endocrinol (Oxf) 60: 382-388, 2004.
10. Heddle R, Fone D, Dent J, Horowitz M. Stimulation of pyloric motility by intraduodenal dextrose in normal subjects. Gut 29: 1349-1357, 1988.
11. Lavin JH, Wittert G, Sun WM, Horowitz M, Morley JE, Read NW. Appetite regulation by carbohydrate: role of blood glucose and gastrointestinal hormones. Am J Physiol Endocrinol Metab 271: E209-E214, 1996.
12. Lin HC, Doty JE, Reedy TJ, Meyer JH. Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient. Am J Physiol Gastrointest Liver Physiol 256: G404-G411, 1989.
13. Little TJ, Doran S, Meyer JH, Smout AJ, O'Donovan DG, Wu KL, Jones KL, Wishart J, Rayner CK, Horowitz M, Feinle-Bisset C. The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. Am J Physiol Endocrinol Metab 291: E647-E655, 2006.
14. Meeroff JC, Go VL, Phillips SF. Control of gastric emptying by osmolality of duodenal contents in man. Gastroenterology 68: 1144-1151, 1975.
15. Meyer JH, Jones RS. Canine pancreatic responses to intestinally perfused fat and products of fat digestion. Am J Physiol 226: 1178-1187, 1974.
16. Mundinger TO, Cummings DE, Taborsky GJ Jr. Direct stimulation of ghrelin secretion by sympathetic nerves. Endocrinology 147: 2893-2901, 2006.
17. Parker BA, Doran S, Wishart J, Horowitz M, Chapman IM. Effects of small intestinal and gastric glucose administration on the suppression of plasma ghrelin concentrations in healthy older men and women. Clin Endocrinol (Oxf) 62: 539-546, 2005.
18. Pilichiewicz AN, Chaikomin R, Brennan IM, Wishart JM, Rayner CK, Jones KL, Smout AJ, Horowitz M, Feinle-Bisset C. Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. Am J Physiol Endocrinol Metab 293: E743-E753, 2007.
19. Saad MF, Bernaba B, Hwu CM, Jinagouda S, Fahmi S, Kogosov E, Boyadjian R. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87: 3997-4000, 2002.
20. Tack J, Depoortere I, Bisschops R, Delporte C, Coulie B, Meulemans A, Janssens J, Peeters T. Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 55: 327-333, 2006.
21. Williams DL, Cummings DE, Grill HJ, Kaplan JM. Meal-related ghrelin suppression requires postgastric feedback. Endocrinology 144: 2765-2767, 2003.