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Volumn 66, Issue 2, 2008, Pages 111-118

Pilot study: Absorption and efficacy of multiple hormones delivered in a single cream applied to the mucous membranes of the labia and vagina

Author keywords

Absorption; Estradiol; Estriol; Gonadal steroid hormones; Progesterone; Testosterone; Vaginal creams

Indexed keywords

BASE; ESTRADIOL; ESTRIOL; PRASTERONE; PROGESTERONE; TESTOSTERONE PROPIONATE; UNCLASSIFIED DRUG; VERSABASE;

EID: 51149098599     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000128599     Document Type: Article
Times cited : (14)

References (61)
  • 1
    • 0017761523 scopus 로고
    • Vaginal absorption of estrone and 17β-estradiol
    • Schiff I, Tulchinsky D, Ryan K: Vaginal absorption of estrone and 17β-estradiol. Fertil Steril 1977;28;1063-1066.
    • (1977) Fertil Steril , vol.28 , pp. 1063-1066
    • Schiff, I.1    Tulchinsky, D.2    Ryan, K.3
  • 3
    • 0019185180 scopus 로고
    • The vaginal absorption of oestrogens in post-menopausal women
    • Punnonen R, Vilska S, Grönroos M, Rauramo L: The vaginal absorption of oestrogens in post-menopausal women. Maturitas 1980;2:321-326.
    • (1980) Maturitas , vol.2 , pp. 321-326
    • Punnonen, R.1    Vilska, S.2    Grönroos, M.3    Rauramo, L.4
  • 4
    • 0021218530 scopus 로고
    • Estriol: Absorption after long-term vaginal treatment and gastrointestinal absorption as influenced by a meal
    • Heimer G, Englund D: Estriol: absorption after long-term vaginal treatment and gastrointestinal absorption as influenced by a meal. Acta Obstet Gynecol Scand 1984;63:563-567.
    • (1984) Acta Obstet Gynecol Scand , vol.63 , pp. 563-567
    • Heimer, G.1    Englund, D.2
  • 5
    • 0023026667 scopus 로고
    • Plasma oestriol following vaginal administration: Morning versus evening insertion and influence of food
    • Heimer G, Englund D: Plasma oestriol following vaginal administration: morning versus evening insertion and influence of food. Maturitas 1986;8:239-243
    • (1986) Maturitas , vol.8 , pp. 239-243
    • Heimer, G.1    Englund, D.2
  • 6
    • 0021021622 scopus 로고
    • Vaginal absorption of two estriol preparations: A comparative study in postmenopausal women
    • Mattson L, Cullberg G: Vaginal absorption of two estriol preparations: a comparative study in postmenopausal women. Acta Obstet Gynecol Scand 1983;62:393-396.
    • (1983) Acta Obstet Gynecol Scand , vol.62 , pp. 393-396
    • Mattson, L.1    Cullberg, G.2
  • 7
    • 0023620552 scopus 로고
    • Nonoral routes of estrogen administration
    • Cedars M, Judd H: Nonoral routes of estrogen administration. Menopause 1987;14:269-298.
    • (1987) Menopause , vol.14 , pp. 269-298
    • Cedars, M.1    Judd, H.2
  • 8
    • 0024217513 scopus 로고
    • Serum levels of oestrogens, progesterone, follicle-stimulating hormone and sex-hormone-binding globulin during simultaneous vaginal administration of 17 beta-oestradiol and progesterone in the pre- and post-menopause
    • Carlström K, Pschera H, Lunnell N: Serum levels of oestrogens, progesterone, follicle-stimulating hormone and sex-hormone-binding globulin during simultaneous vaginal administration of 17 beta-oestradiol and progesterone in the pre- and post-menopause. Maturitas 1988;10:307-316.
    • (1988) Maturitas , vol.10 , pp. 307-316
    • Carlström, K.1    Pschera, H.2    Lunnell, N.3
  • 9
    • 0037219523 scopus 로고    scopus 로고
    • Long-term administration of intravaginal dehydroepiandrosterone on regression of low-grade cervical dysplasia - a pilot study
    • Suh-Burgmann E, Sivret J, Duska L, Carmen M, Seiden M: Long-term administration of intravaginal dehydroepiandrosterone on regression of low-grade cervical dysplasia - a pilot study. Gynecol Obstet Invest 2003;55:25-31.
    • (2003) Gynecol Obstet Invest , vol.55 , pp. 25-31
    • Suh-Burgmann, E.1    Sivret, J.2    Duska, L.3    Carmen, M.4    Seiden, M.5
  • 10
    • 0019433205 scopus 로고
    • Oestrogens, gonadotropins and prolactin after intra-vaginal administration of oestriol in post-menopausal women
    • Keller PJ, Riedmann R, Fischer M, Gerber C: Oestrogens, gonadotropins and prolactin after intra-vaginal administration of oestriol in post-menopausal women. Maturitas 1981;3:47-53.
    • (1981) Maturitas , vol.3 , pp. 47-53
    • Keller, P.J.1    Riedmann, R.2    Fischer, M.3    Gerber, C.4
  • 11
    • 0017796942 scopus 로고
    • Absorption of estrogens from vaginal creams
    • Rigg LA, Hermann H, Yen SS: Absorption of estrogens from vaginal creams. N Engl J Med 1978;298:195-197.
    • (1978) N Engl J Med , vol.298 , pp. 195-197
    • Rigg, L.A.1    Hermann, H.2    Yen, S.S.3
  • 12
    • 0033662080 scopus 로고    scopus 로고
    • Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women
    • Rosano G, Webb C, Chierchia S, Morgani G, Gabraele M, Sarrel P, Ziegler D, Collins P: Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women. J Am Col Cardiol 2000;36:2154-2159.
    • (2000) J Am Col Cardiol , vol.36 , pp. 2154-2159
    • Rosano, G.1    Webb, C.2    Chierchia, S.3    Morgani, G.4    Gabraele, M.5    Sarrel, P.6    Ziegler, D.7    Collins, P.8
  • 13
    • 0030062253 scopus 로고    scopus 로고
    • Percutaneous absorption of hydrocortisone and testosterone on the vulva and forearm: Effect of the menopause and site
    • Oriba H, Bucks D, Maibach H: Percutaneous absorption of hydrocortisone and testosterone on the vulva and forearm: effect of the menopause and site. Br J Derm 1996;134:229-233.
    • (1996) Br J Derm , vol.134 , pp. 229-233
    • Oriba, H.1    Bucks, D.2    Maibach, H.3
  • 14
    • 0024391104 scopus 로고
    • Drug absorption through mucosal membranes: Effect of mucosal route and penetrant hydrophilicity
    • Corbo D, Liu JC, Chien Y: Drug absorption through mucosal membranes: effect of mucosal route and penetrant hydrophilicity. Pharmac Res 1989;6:848-852.
    • (1989) Pharmac Res , vol.6 , pp. 848-852
    • Corbo, D.1    Liu, J.C.2    Chien, Y.3
  • 15
    • 0021336677 scopus 로고
    • Serum levels of sex hormone in vulvar lichen sclerosus, and the effect of topical testosterone
    • Friedrich E, Kalra P: Serum levels of sex hormone in vulvar lichen sclerosus, and the effect of topical testosterone. N Engl J Med 1981;310:488-491.
    • (1981) N Engl J Med , vol.310 , pp. 488-491
    • Friedrich, E.1    Kalra, P.2
  • 16
    • 0027233408 scopus 로고
    • Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone
    • Nahoul K, Dehennin L, Jondet M, Roger M: Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone. Maturitas 1993;16:185-202.
    • (1993) Maturitas , vol.16 , pp. 185-202
    • Nahoul, K.1    Dehennin, L.2    Jondet, M.3    Roger, M.4
  • 17
    • 0020567867 scopus 로고
    • Biological effects of various doses of vaginally administered conjugated equine estrogens in postmenopausal women
    • Mandel F, Geola F, Meldrum D, Lu J, Eggena P, Sambhi M, Hershmann J, Judd H: Biological effects of various doses of vaginally administered conjugated equine estrogens in postmenopausal women. J Clin Endo Met 1983;57:133-139.
    • (1983) J Clin Endo Met , vol.57 , pp. 133-139
    • Mandel, F.1    Geola, F.2    Meldrum, D.3    Lu, J.4    Eggena, P.5    Sambhi, M.6    Hershmann, J.7    Judd, H.8
  • 18
    • 0028841626 scopus 로고
    • Transvaginal estriol administration in postmenopausal women: A double blind comparative study of two different doses
    • Bottiglione F, Volpe A, Esposito G, Aloysio D: Transvaginal estriol administration in postmenopausal women: a double blind comparative study of two different doses. Maturitas 1995;22:227-232.
    • (1995) Maturitas , vol.22 , pp. 227-232
    • Bottiglione, F.1    Volpe, A.2    Esposito, G.3    Aloysio, D.4
  • 19
    • 0019125316 scopus 로고
    • Plasma estriol and its conjugates following oral and vaginal administration of estriol to postmenopausal women: Correlations with gonadotropin levels
    • Schiff I, Tulchinsky D, Ryan K, Kadner S, Levitz M: Plasma estriol and its conjugates following oral and vaginal administration of estriol to postmenopausal women: correlations with gonadotropin levels. Am J Obstet Gynecol 1980;138:1137-1141.
    • (1980) Am J Obstet Gynecol , vol.138 , pp. 1137-1141
    • Schiff, I.1    Tulchinsky, D.2    Ryan, K.3    Kadner, S.4    Levitz, M.5
  • 20
    • 0030687966 scopus 로고    scopus 로고
    • Randomized, double-blind, dose-ranging study of the endometrial effects of a vaginal progesterone gel in estrogen-treated postmenopausal women
    • Ross D, Cooper A, Pryse-Davies J, Bergeron C, Collins W, Whitehead M: Randomized, double-blind, dose-ranging study of the endometrial effects of a vaginal progesterone gel in estrogen-treated postmenopausal women. Am J Obstet Gynecol 1997;177:937-941.
    • (1997) Am J Obstet Gynecol , vol.177 , pp. 937-941
    • Ross, D.1    Cooper, A.2    Pryse-Davies, J.3    Bergeron, C.4    Collins, W.5    Whitehead, M.6
  • 21
    • 0031920761 scopus 로고    scopus 로고
    • Plasma concentrations of progesterone are higher in the uterine artery than in the radial artery after vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women
    • Cicinelli E, Cignarelli M, Sabatelli S, Romano F, Schonauer L, Padovano R, Einer-Jensen N: Plasma concentrations of progesterone are higher in the uterine artery than in the radial artery after vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women. Fertil Steril 1998;69:471-473.
    • (1998) Fertil Steril , vol.69 , pp. 471-473
    • Cicinelli, E.1    Cignarelli, M.2    Sabatelli, S.3    Romano, F.4    Schonauer, L.5    Padovano, R.6    Einer-Jensen, N.7
  • 22
    • 0033975915 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetics of crinone 8% administered vaginally versus prometrium administered orally in postmenopausal women
    • Levine H, Watson N, Comparison of the pharmacokinetics of crinone 8% administered vaginally versus prometrium administered orally in postmenopausal women. Fertil Steril 2000;73:516-521.
    • (2000) Fertil Steril , vol.73 , pp. 516-521
    • Levine, H.1    Watson, N.2
  • 23
    • 0030096228 scopus 로고    scopus 로고
    • A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity
    • Ware J Jr, Kosinski M, Keller SD: A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996;34:220-233.
    • (1996) Med Care , vol.34 , pp. 220-233
    • Ware Jr, J.1    Kosinski, M.2    Keller, S.D.3
  • 24
    • 0031804690 scopus 로고    scopus 로고
    • Patient satisfaction and quality of life: Humanistic outcomes
    • Gourley GA, Duncan DV: Patient satisfaction and quality of life: humanistic outcomes. Am J Manag Care 1998;4:746-752.
    • (1998) Am J Manag Care , vol.4 , pp. 746-752
    • Gourley, G.A.1    Duncan, D.V.2
  • 26
    • 0029664491 scopus 로고    scopus 로고
    • Assessment of quality-of-life outcomes
    • Testa MA, Simonson DC: Assessment of quality-of-life outcomes. N Engl J Med 1996;334:835-840.
    • (1996) N Engl J Med , vol.334 , pp. 835-840
    • Testa, M.A.1    Simonson, D.C.2
  • 28
    • 0019422863 scopus 로고
    • Intravaginal administration of progesterone: Enhanced absorption after estrogen treatment
    • Villanueva B, Casper RF, Yen SC: Intravaginal administration of progesterone: enhanced absorption after estrogen treatment. Fertil Steril 1981;35:433-437.
    • (1981) Fertil Steril , vol.35 , pp. 433-437
    • Villanueva, B.1    Casper, R.F.2    Yen, S.C.3
  • 30
    • 0029092131 scopus 로고
    • Review of the endometrial safety during intravaginal treatment with estriol
    • Vooijs GP, Geurts TBP: Review of the endometrial safety during intravaginal treatment with estriol. Obstet Gynecol 1995;62:101-106.
    • (1995) Obstet Gynecol , vol.62 , pp. 101-106
    • Vooijs, G.P.1    Geurts, T.B.P.2
  • 31
    • 0024358792 scopus 로고
    • The risk of breast cancer after estrogen and estrogen-progestin replacement
    • Bergkivist L, Adami H, Persson I, Hoover R, Schairer C: The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med 1985;321:293-297.
    • (1985) N Engl J Med , vol.321 , pp. 293-297
    • Bergkivist, L.1    Adami, H.2    Persson, I.3    Hoover, R.4    Schairer, C.5
  • 32
    • 0032096228 scopus 로고    scopus 로고
    • A cohort study of hormone replacement therapy given to women previously treated for breast cancer
    • Dew J, Eden J, Beller E, Magarey C, Schwartz P, Crea P, Wren B: A cohort study of hormone replacement therapy given to women previously treated for breast cancer. Climacteric 1998;1:137-142.
    • (1998) Climacteric , vol.1 , pp. 137-142
    • Dew, J.1    Eden, J.2    Beller, E.3    Magarey, C.4    Schwartz, P.5    Crea, P.6    Wren, B.7
  • 33
    • 0037354228 scopus 로고    scopus 로고
    • A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer
    • Dew J, Wren B, Eden J: A cohort study of topical vaginal estrogen therapy in women previously treated for breast cancer. Climacteric 2003;6:45-52.
    • (2003) Climacteric , vol.6 , pp. 45-52
    • Dew, J.1    Wren, B.2    Eden, J.3
  • 34
    • 14044266896 scopus 로고    scopus 로고
    • Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort
    • Fournier A, Berrino F, Riboli E, Avenel V: Clavel-Chapelon F: Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int J Cancer 2004;114:448-454.
    • (2004) Int J Cancer , vol.114 , pp. 448-454
    • Fournier, A.1    Berrino, F.2    Riboli, E.3    Avenel, V.4    Clavel-Chapelon, F.5
  • 35
    • 36549076409 scopus 로고    scopus 로고
    • Unequal risks for breast cancer associated with different hormone replacement therapies; results from the E3N cohort study
    • Fournier A, Berrino F, Clavel-Chapelon F: Unequal risks for breast cancer associated with different hormone replacement therapies; results from the E3N cohort study. Breast Cancer Res Treat 2008;107:103-111.
    • (2008) Breast Cancer Res Treat , vol.107 , pp. 103-111
    • Fournier, A.1    Berrino, F.2    Clavel-Chapelon, F.3
  • 36
    • 33845383231 scopus 로고    scopus 로고
    • Breast cancer risk in postmenopausal women using estrogen-only therapy
    • Lyytinen H, Pukkala E, Ylikorkala O: Breast cancer risk in postmenopausal women using estrogen-only therapy. Obstet Gynecol 2006;108:1354-1360.
    • (2006) Obstet Gynecol , vol.108 , pp. 1354-1360
    • Lyytinen, H.1    Pukkala, E.2    Ylikorkala, O.3
  • 37
    • 33644943010 scopus 로고    scopus 로고
    • Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: A case-control study
    • Rosenberg L, Magnusson C, Lindstrom E, Wedren S, Hall P, Dickman P: Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: a case-control study. Breast Cancer Res 2006;8:R11.
    • (2006) Breast Cancer Res , vol.8
    • Rosenberg, L.1    Magnusson, C.2    Lindstrom, E.3    Wedren, S.4    Hall, P.5    Dickman, P.6
  • 38
    • 0021910523 scopus 로고
    • Benefits of vaginal estriol cream combined with clonidine HCl for menopausal syndrome treatment
    • Blum M: Benefits of vaginal estriol cream combined with clonidine HCl for menopausal syndrome treatment. Clin Exp Obstet Gynecol 1985;12:1-2.
    • (1985) Clin Exp Obstet Gynecol , vol.12 , pp. 1-2
    • Blum, M.1
  • 39
    • 0022260350 scopus 로고
    • Vaginal oestriol: Effective menopausal therapy not associated with endometrial hyperplasia
    • Fink RS, Collins W, Papadaki L, O'Reilly B, Ginsburg J: Vaginal oestriol: effective menopausal therapy not associated with endometrial hyperplasia. J Gynaec Endocrinol 1985;1:1-11.
    • (1985) J Gynaec Endocrinol , vol.1 , pp. 1-11
    • Fink, R.S.1    Collins, W.2    Papadaki, L.3    O'Reilly, B.4    Ginsburg, J.5
  • 41
    • 0036209986 scopus 로고    scopus 로고
    • Use of low potency estrogens does not reduce the risk of hip fractures
    • Michaelsson K, Baron J, Farahmand B, Ljunghall S: Use of low potency estrogens does not reduce the risk of hip fractures. Bone 2002;30:613-618.
    • (2002) Bone , vol.30 , pp. 613-618
    • Michaelsson, K.1    Baron, J.2    Farahmand, B.3    Ljunghall, S.4
  • 42
    • 0020382899 scopus 로고
    • Ovestin vaginal cream and suppositories for the treatment of menopausal vaginal atrophy
    • Trevoux R, Van der Velden W, Popovis D: Ovestin vaginal cream and suppositories for the treatment of menopausal vaginal atrophy. Reproduction 1982;6:101-106.
    • (1982) Reproduction , vol.6 , pp. 101-106
    • Trevoux, R.1    Van der Velden, W.2    Popovis, D.3
  • 43
    • 0033669251 scopus 로고    scopus 로고
    • Pharmacokinetics of the progesterone-containing vaginal tablet and its use in assisted reproduction
    • Levy T, Yairi Y, Bar-Hava I, Shalev J, Orvieto R, Ben-Rafael Z: Pharmacokinetics of the progesterone-containing vaginal tablet and its use in assisted reproduction. Steroids 2000;65:645-649.
    • (2000) Steroids , vol.65 , pp. 645-649
    • Levy, T.1    Yairi, Y.2    Bar-Hava, I.3    Shalev, J.4    Orvieto, R.5    Ben-Rafael, Z.6
  • 44
    • 24144485432 scopus 로고    scopus 로고
    • Pharmacology of estrogens and progestogens: Influence of different routes of administration
    • Kuhl H: Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric 2005;8(suppl 1):3-63.
    • (2005) Climacteric , vol.8 , Issue.SUPPL. 1 , pp. 3-63
    • Kuhl, H.1
  • 46
    • 0028900416 scopus 로고
    • Influence of route of administration on progesterone metabolism
    • de Lignieres B, Dennerstein L, Backstrom T: Influence of route of administration on progesterone metabolism. Maturitas 1995;21:251-257.
    • (1995) Maturitas , vol.21 , pp. 251-257
    • de Lignieres, B.1    Dennerstein, L.2    Backstrom, T.3
  • 47
    • 51149116691 scopus 로고    scopus 로고
    • Vaginal progesterone (P) in menopause: Long term acceptability of a new therapeutic option for physiological progesterone replacement
    • Jaaskelainen A, Shaerer E, de Ziegler D: Vaginal progesterone (P) in menopause: long term acceptability of a new therapeutic option for physiological progesterone replacement. Maturitas 1997;27(suppl 1):57.
    • (1997) Maturitas , vol.27 , Issue.SUPPL. 1 , pp. 57
    • Jaaskelainen, A.1    Shaerer, E.2    de Ziegler, D.3
  • 50
    • 0032894681 scopus 로고    scopus 로고
    • Androgens down-regulate bcl-2 proto-oncogene expression in ZR-75-1 human breast cancer cells
    • Lapointe J, Fournier A, Richard V, Labrie C: Androgens down-regulate bcl-2 proto-oncogene expression in ZR-75-1 human breast cancer cells. Endocrinology 1999;140:1416-1421.
    • (1999) Endocrinology , vol.140 , pp. 1416-1421
    • Lapointe, J.1    Fournier, A.2    Richard, V.3    Labrie, C.4
  • 51
    • 0033818180 scopus 로고    scopus 로고
    • Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression
    • Zhou J, Ng S, Adesanya-Famuiya O, Anderson K, Bondy C: Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB J 2000;14:1725-1730.
    • (2000) FASEB J , vol.14 , pp. 1725-1730
    • Zhou, J.1    Ng, S.2    Adesanya-Famuiya, O.3    Anderson, K.4    Bondy, C.5
  • 53
    • 14944359093 scopus 로고    scopus 로고
    • Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy
    • Dimitrakakis C, Jones R, Liu A, Bondy C: Breast cancer incidence in postmenopausal women using testosterone in addition to usual hormone therapy. Menopause 2004;11:531-535.
    • (2004) Menopause , vol.11 , pp. 531-535
    • Dimitrakakis, C.1    Jones, R.2    Liu, A.3    Bondy, C.4
  • 54
    • 34247643957 scopus 로고    scopus 로고
    • Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal women
    • Hofling M, Hirschberg Q, Skoog L, Tani E, Hagerstrom T, von Schoultz B: Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal women. Menopause 2007;14:1-8.
    • (2007) Menopause , vol.14 , pp. 1-8
    • Hofling, M.1    Hirschberg, Q.2    Skoog, L.3    Tani, E.4    Hagerstrom, T.5    von Schoultz, B.6
  • 55
    • 0037333156 scopus 로고    scopus 로고
    • Tibolone is not converted by human aromatase to 7-alpha methyl 17-alpha ethynylestradiol: Analyses with sensitive bioassays for estrogens and androgens with LC-MSMS
    • de Goyer M, Oppers-Tiemissen H, Leysen D, Verheul H, Kloosterboer J: Tibolone is not converted by human aromatase to 7-alpha methyl 17-alpha ethynylestradiol: analyses with sensitive bioassays for estrogens and androgens with LC-MSMS. Steroids 2003;68:235-243.
    • (2003) Steroids , vol.68 , pp. 235-243
    • de Goyer, M.1    Oppers-Tiemissen, H.2    Leysen, D.3    Verheul, H.4    Kloosterboer, J.5
  • 56
    • 33746387475 scopus 로고    scopus 로고
    • Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women
    • Tamimi R, Hankinson S, Chen W, Rosner B, Colditz G: Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006;166:1483-1488.
    • (2006) Arch Intern Med , vol.166 , pp. 1483-1488
    • Tamimi, R.1    Hankinson, S.2    Chen, W.3    Rosner, B.4    Colditz, G.5
  • 57
    • 0042018741 scopus 로고    scopus 로고
    • Million Women Study Collaborators: Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003;362:419-427.
    • Million Women Study Collaborators: Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003;362:419-427.
  • 58
    • 34047097773 scopus 로고    scopus 로고
    • NIH State-of-the-Science Conference Statement on management of menopause-related symptoms. NIH Consens Stat Sci Statements 2005;22:1-38.
    • NIH State-of-the-Science Conference Statement on management of menopause-related symptoms. NIH Consens Stat Sci Statements 2005;22:1-38.
  • 59
    • 0032439480 scopus 로고    scopus 로고
    • Medical outcomes study short form 36: Testing and cross-validating a second-order factorial structure for health system employees
    • Reed PJ: Medical outcomes study short form 36: testing and cross-validating a second-order factorial structure for health system employees. Health Serv Res 1998;33:1361-1380.
    • (1998) Health Serv Res , vol.33 , pp. 1361-1380
    • Reed, P.J.1
  • 60


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