Automated evaluation of HER-2/neu immunohistochemical expression in breast cancer using digital microscopy

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI

Volumn , Issue , 2008, Pages 808-811

  Gavrielides, Marios A ^a   Masmoudi, Hela ^a,b   Petrick, Nicholas ^a   Myers, Kyle J ^a   Hewitt, Stephen M ^c  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^b George Washington University   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Biomarker imaging; Computer aided analysis; HER2 neu; Immunohistochemistry; Microscopy imaging

Indexed keywords

COMPUTER NETWORKS; DIGITAL ARITHMETIC; FEATURE EXTRACTION; PAINTING; TECHNICAL PRESENTATIONS;

BIOMARKER IMAGING; COMPUTER AIDED ANALYSIS; HER2/NEU; IMMUNOHISTOCHEMISTRY; MICROSCOPY IMAGING;

AUTOMATION;

EID: 51049121794     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ISBI.2008.4541119     Document Type: Conference Paper

References (8)

1. Slamon DJ, Clark GM, et. al. Human breast cancer: correlation of relapse and survival with amplification of the HER2/neu oncogene. Science 1987; 235:177-182.
2. Ross, J.S. and J.A. Fletcher, The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Stem Cells, 1998. 16: p. 413-428.
3. Wolff, A.C., M.E.H. Hammond, et. al, American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Path Lab Med, 2007. 131: p. 18-42.
4. Hsu, C.-Y., D.M.-T. Ho, et. al. , Interobserver Reproducibility of Her-2/neu Protein Overexpression in Invasive Breast Carcinoma Using the DAKO HercepTest. Am. Jour of Clin. Pathol., 2002. 118(5): p. 693-698.
5. Hatanaka, Y., Kashizume K et al., Quantitative immunohistochemical evaluation of HER2/neu expression with Herceptest in breast carcinoma by image analysis. Pathology International, 2001. 51: p. 33-36.
6. Ciampa A, Xu B, et al. HER-2 status in breast cancer, correlation of Gene amplification by FISH with immunohistochemistry expression using Advanced Cellular Imaging System. Applied Immunohistochemistry Molecular Morphology 2006; 14:132-137.
7. Soille, P., Morphological image analysis: principles and applications, 2nd ed. 2003, Berlin: Springer-Verlag.
8. Raimondo, F., M.A. Gavrielides, et. al., Automated evaluation of Her2/neu status in breast tissue from fluorescent in situ hybridization images. IEEE Trans. on Image Proc., 2005. 14(9): p. 1288-1299.